Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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D129824-25mg
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25mg |
2
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$55.90
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D129824-100mg
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100mg |
3
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$184.90
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D129824-500mg
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500mg |
3
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$832.90
|
|
Potent and selective carbonic anhydrase II inhibitor
| Synonyms | Dorzolomide hydrochloride | (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide hydrochloride | AKOS000304216 | CAS-130693-82-2 | HY-B0109A | MK 0507 | MK-0507 | Dorzolamide (hydrochloride) | DORZOLAMIDE HYDR |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti glaucoma agent which is a carbonic anhydrase inhibitor. .Potent and selective carbonic anhydrase II inhibitor (IC 50 values are 0.2, 43 and 52 nM for CA II, IV and IX respectively). Decreases the product |
| Storage Temp | Store at 2-8°C |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Action Type | INHIBITOR |
| Mechanism of action | Carbonic anhydrase II inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Dorzolamide HCl is a carbonic anhydrase inhibitor. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Thiophenes |
| Subclass | 2,3,5-trisubstituted thiophenes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 2,3,5-trisubstituted thiophenes |
| Alternative Parents | Aralkylamines Thiopyrans Organosulfonamides Sulfones Heteroaromatic compounds Aminosulfonyl compounds Dialkylamines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 2,3,5-trisubstituted thiophene - Aralkylamine - Organosulfonic acid amide - Thiopyran - Sulfone - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Aminosulfonyl compound - Heteroaromatic compound - Secondary aliphatic amine - Secondary amine - Organic oxygen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Organosulfur compound - Organopnictogen compound - Organic oxide - Hydrochloride - Hydrocarbon derivative - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 2,3,5-trisubstituted thiophenes. These are organic compounds containing a thiophene that is trisubstituted at the C-2, C3- and C5-positions. |
| External Descriptors | hydrochloride - organoammonium salt |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504764348 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764348 |
| IUPAC Name | (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride |
| INCHI | InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1 |
| InChIKey | OSRUSFPMRGDLAG-QMGYSKNISA-N |
| Smiles | CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl |
| Isomeric SMILES | CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl |
| Alternate CAS | 120279-96-1 |
| Molecular Weight | 360.9 |
| Beilstein | 5896026 |
| Reaxy-Rn | 8518917 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8518917&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jan 16, 2023 | D129824 | |
| Certificate of Analysis | Mar 12, 2022 | D129824 | |
| Certificate of Analysis | Mar 11, 2022 | D129824 |
| Solubility | Soluble in water (14 mg/ml at 25 °C), methanol, DMSO (<1 mg/ml at 25 °C), ethanol (sparingly), and DMF (sparingly). |
|---|---|
| Specific Rotation[α] | -8° (C=1,MeOH) |
| Melt Point(°C) | 281 °C(dec.) |
| Molecular Weight | 360.900 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 3 |
| Exact Mass | 360.004 Da |
| Monoisotopic Mass | 360.004 Da |
| Topological Polar Surface Area | 151.000 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 534.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |