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Dorzolamide HCl - ≥98%, high purity , Carbonic anhydrase II inhibitor, CAS No.130693-82-2, Carbonic anhydrase II inhibitor

    Grade & Purity:
  • ≥98%
In stock
Item Number
D129824
Grouped product items
SKU Size
Availability
Price Qty
D129824-25mg
25mg
2
$55.90
D129824-100mg
100mg
3
$184.90
D129824-500mg
500mg
3
$832.90

Potent and selective carbonic anhydrase II inhibitor

Basic Description

Synonyms Dorzolomide hydrochloride | (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide hydrochloride | AKOS000304216 | CAS-130693-82-2 | HY-B0109A | MK 0507 | MK-0507 | Dorzolamide (hydrochloride) | DORZOLAMIDE HYDR
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti glaucoma agent which is a carbonic anhydrase inhibitor. .Potent and selective carbonic anhydrase II inhibitor (IC 50 values are 0.2, 43 and 52 nM for CA II, IV and IX respectively). Decreases the product
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action Carbonic anhydrase II inhibitor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Dorzolamide HCl is a carbonic anhydrase inhibitor.
An inhibitor of carbonic anhydrase.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Thiophenes
Subclass 2,3,5-trisubstituted thiophenes
Intermediate Tree Nodes Not available
Direct Parent 2,3,5-trisubstituted thiophenes
Alternative Parents Aralkylamines  Thiopyrans  Organosulfonamides  Sulfones  Heteroaromatic compounds  Aminosulfonyl compounds  Dialkylamines  Organopnictogen compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents 2,3,5-trisubstituted thiophene - Aralkylamine - Organosulfonic acid amide - Thiopyran - Sulfone - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Aminosulfonyl compound - Heteroaromatic compound - Secondary aliphatic amine - Secondary amine - Organic oxygen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Organosulfur compound - Organopnictogen compound - Organic oxide - Hydrochloride - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as 2,3,5-trisubstituted thiophenes. These are organic compounds containing a thiophene that is trisubstituted at the C-2, C3- and C5-positions.
External Descriptors hydrochloride - organoammonium salt

Associated Targets(Human)

POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764348
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764348
IUPAC Name (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride
INCHI InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
InChIKey OSRUSFPMRGDLAG-QMGYSKNISA-N
Smiles CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl
Isomeric SMILES CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl
Alternate CAS 120279-96-1
Molecular Weight 360.9
Beilstein 5896026
Reaxy-Rn 8518917
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8518917&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
F1510001 Certificate of Analysis Jan 16, 2023 D129824
C2205310 Certificate of Analysis Mar 12, 2022 D129824
C2205298 Certificate of Analysis Mar 11, 2022 D129824

Chemical and Physical Properties

Solubility Soluble in water (14 mg/ml at 25 °C), methanol, DMSO (<1 mg/ml at 25 °C), ethanol (sparingly), and DMF (sparingly).
Specific Rotation[α] -8° (C=1,MeOH)
Melt Point(°C) 281 °C(dec.)
Molecular Weight 360.900 g/mol
XLogP3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 3
Exact Mass 360.004 Da
Monoisotopic Mass 360.004 Da
Topological Polar Surface Area 151.000 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 534.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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