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Dorsomorphin 2HCl - ≥98%, high purity , CAS No.1219168-18-9

1 Citations

COA

Grade & Purity:

≥98%

Cas Number: 1219168-18-9
Molecular Weight: 472.41
PubChem CID: 49761481
PubChem SID: 504770910

In stock

Item Number

D129758

Grouped product items
SKU	Size	Availability	Price
D129758-5mg	5mg	3	$58.90
D129758-10mg	10mg	3	$88.90
D129758-50mg	50mg	3	$296.90

Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor.

View related series

AMPK (95) Autophagy (1917) DNA Methylation (216) Epigenetics (1496) PI3K/Akt/mTOR (765) TGF-beta/Smad (303) TGF-β Receptor (70)

Basic Description

Synonyms	BML-275 \| 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2) \| Compound C dihydrochloride \| BML275 dihydrochloride \| BML 275 dihydrochloride
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 re
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits BMP type I receptor. A potent and selective AMPK inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrimidines and pyrimidine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrimidines and pyrimidine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyrimidines
Alternative Parents	Pyrazolo[1,5-a]pyrimidines Phenoxy compounds Phenol ethers Alkyl aryl ethers Pyridines and derivatives Piperidines Pyrazoles Heteroaromatic compounds Trialkylamines Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	5-phenylpyrimidine - Pyrazolo[1,5-a]pyrimidine - Pyrazolopyrimidine - Phenoxy compound - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Pyridine - Piperidine - Azole - Heteroaromatic compound - Pyrazole - Tertiary aliphatic amine - Tertiary amine - Ether - Azacycle - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Amine - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyrimidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrimidine ring through a CC or CN bond. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504770910
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770910
IUPAC Name	6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride
INCHI	InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
InChIKey	RJDVIJJQKMGPMV-UHFFFAOYSA-N
Smiles	C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
Isomeric SMILES	C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
Molecular Weight	472.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
B1526027	Certificate of Analysis	Jun 06, 2024	D129758
A2213310	Certificate of Analysis	Feb 11, 2022	D129758
A2213307	Certificate of Analysis	Feb 11, 2022	D129758
A2213313	Certificate of Analysis	Feb 11, 2022	D129758

Chemical and Physical Properties

Solubility	Soluble in water (100 mM), and DMSO (20 mM).
Molecular Weight	472.400 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	471.159 Da
Monoisotopic Mass	471.159 Da
Topological Polar Surface Area	55.600 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	514.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

Citations of This Product

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