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DMXAA (Vadimezan) - ≥98%, high purity , CAS No.117570-53-3

6 Citations COA COA
In stock
Item Number
D129922
Grouped product items
SKU Size
Availability
 Price Qty
D129922-5mg
5mg
7
$29.90
D129922-25mg
25mg
3
$79.90
D129922-100mg
100mg
4
$239.90
D129922-250mg
250mg
2
$479.90
D129922-1g
1g
1
$999.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Vascular disrupting agent. VEGFR inhibitor.

View related series
Anti-infection (2803) IFNAR (25) Immunology/Inflammation (1929) Influenza Virus (253) Oxaanthracene (36) Six-Membered Heterocyclic Compounds (1696) STING (52) Virus (1811)

Basic Description

Synonyms ASA404 | 5,6-MeXAA | NSC-640488 | 9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo- | BCPP000255 | J-003637 | 5,6-Mexaa | AC-24559 | NSC-640488 | AS-16852 | DTXSID2040949 | EN300-396606 | NCGC00165783-01 | SW219898-1 | VADIMEZAN [WHO-DD] | (5,6-dimethyl-9-ox
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms DMXAA is an apoptosis inducer, and an anti-vascular. DMXAA is an inhibitor of NQO1, Flk-1 and Flt-1.Vascular disrupting agent. VEGFR inhibitor. Potent type I interferon inducer. Increases vascular permeability and vascular endothelial apoptosis. Inhibits
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.
An apoptosis inducer for proteomics research.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzopyrans
Subclass 1-benzopyrans
Intermediate Tree Nodes Dibenzopyrans - Xanthenes
Direct Parent Xanthones
Alternative Parents Chromones  Pyranones and derivatives  Benzenoids  Heteroaromatic compounds  Oxacyclic compounds  Monocarboxylic acids and derivatives  Carboxylic acids  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Xanthone - Chromone - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Oxacycle - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
External Descriptors monocarboxylic acid - xanthones

Associated Targets(Human)

GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BeWo (124 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caco-2 (12174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 320 (353 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SiHa (2051 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BJ (6930 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ishikawa (877 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Tumour suppressor p53/oncoprotein Mdm2 (2075 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L02 (4864 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF S-180 (1031 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MC-38 (857 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Splenocyte (1641 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CT26 (928 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488187781
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488187781
IUPAC Name 2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid
INCHI InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
InChIKey XGOYIMQSIKSOBS-UHFFFAOYSA-N
Smiles CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C
Isomeric SMILES CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C
WGK Germany 3
RTECS ZD5536200
Molecular Weight 282.29
Reaxy-Rn 4262852
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4262852&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot Number Certificate Type Date Item
G2326412 Certificate of Analysis May 09, 2025 D129922
G2326397 Certificate of Analysis May 09, 2025 D129922
G2326399 Certificate of Analysis May 09, 2025 D129922
E2325461 Certificate of Analysis Mar 04, 2025 D129922
E2325458 Certificate of Analysis Mar 04, 2025 D129922
E2325453 Certificate of Analysis Mar 04, 2025 D129922
E2325450 Certificate of Analysis Mar 04, 2025 D129922
E2325452 Certificate of Analysis Mar 04, 2025 D129922
E2325456 Certificate of Analysis Mar 04, 2025 D129922
E2325459 Certificate of Analysis Mar 04, 2025 D129922
E2325457 Certificate of Analysis Mar 04, 2025 D129922
D2508108 Certificate of Analysis Dec 27, 2024 D129922
A2517347 Certificate of Analysis Dec 27, 2024 D129922
A2517348 Certificate of Analysis Dec 27, 2024 D129922
A2517349 Certificate of Analysis Dec 27, 2024 D129922
A2517350 Certificate of Analysis Dec 27, 2024 D129922
D2524051 Certificate of Analysis Dec 27, 2024 D129922
F2414246 Certificate of Analysis May 27, 2024 D129922
F2414251 Certificate of Analysis May 27, 2024 D129922
F2414255 Certificate of Analysis May 27, 2024 D129922
F2414256 Certificate of Analysis May 27, 2024 D129922
G2201285 Certificate of Analysis Apr 07, 2024 D129922
I2124095 Certificate of Analysis Jul 17, 2023 D129922
G2326395 Certificate of Analysis Jul 06, 2023 D129922
K1913123 Certificate of Analysis Jun 08, 2023 D129922
E2325454 Certificate of Analysis May 08, 2023 D129922
D2115334 Certificate of Analysis Jan 17, 2023 D129922
G2201286 Certificate of Analysis Jun 05, 2022 D129922
G2201277 Certificate of Analysis Jun 05, 2022 D129922
G2201210 Certificate of Analysis Jun 05, 2022 D129922
G2201366 Certificate of Analysis Jun 05, 2022 D129922

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Chemical and Physical Properties

Solubility Soluble in DMSO (>10 mg/ml), DMF (~14 mg/ml), 1:1 solution of DMF: PBS (pH=7.2) (~0.5 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Sensitivity heat sensitive
Melt Point(°C) 264 °C
Molecular Weight 282.290 g/mol
XLogP3 3.200
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 282.089 Da
Monoisotopic Mass 282.089 Da
Topological Polar Surface Area 63.600 Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 433.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Qi Long, Yuliang Yang, Fangling Liao, Haoting Chen, Dongyue He, Shengliang Li, Li Pengcheng, Weisheng Guo, Yafang Xiao.  (2023)  NIR-II Fluorescence and PA Imaging Guided Activation of STING Pathway in Photothermal Therapy for Boosting Cancer Immunotherapy by Theranostic Thermosensitive Liposomes.  Journal of Materials Chemistry B,     
2. Yixuan Liu, Qi Sun, Chengfei Zhang, Min Ding, Cheng Wang, Qian Zheng, Zhijie Ma, Haojun Xu, Guoren Zhou, Xiaoming Wang, Zhangjun Cheng, Hongping Xia.  (2023)  STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.  iScience,  26  (107376). 
3. Yuan-Fu Ding, Ziyi Wang, Cheryl H.T. Kwong, Yonghua Zhao, Greta S.P. Mok, Hua-Zhong Yu, Ruibing Wang.  (2023)  Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy.  JOURNAL OF CONTROLLED RELEASE,  360  (82). 
4. Weixin Li, Zhuqi Huang, Yue Luo, Yaqian Cui, Mingjiang Xu, Wu Luo, Gaojun Wu, Guang Liang.  (2023)  Tetrandrine alleviates atherosclerosis via inhibition of STING-TBK1 pathway and inflammation in macrophages.  INTERNATIONAL IMMUNOPHARMACOLOGY,  119  (110139). 
5. Jia Liu, Zuoyu Chen, Lixue Deng, Chundong Yao, Zhixin Zhou, Cheng Zhou, Yawen Bin, Miaodeng Liu, Liping Wang, Lin Wang, Zheng Wang.  (2025)  Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses.  Bioactive Materials,  47  (361). 
6. Lirui Jia, Yang Qin, Xin Li, Hongzhuo Liu, Zhonggui He, Yongjun Wang.  (2025)  STING-activating layered double hydroxide nano-adjuvants for enhanced cancer immunotherapy.  BIOMATERIALS,  321  (123294). 

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