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DMT1 blocker 2 - 99%, high purity , CAS No.1062648-63-8

COA

Grade & Purity:

≥99%

Cas Number: 1062648-63-8
Molecular Weight: 263.29

In stock

Item Number

D651447

Grouped product items
SKU	Size	Availability	Price
D651447-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
D651447-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
D651447-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
D651447-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90
D651447-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,950.90

View related series

Membrane Transporter (607)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo In Vitro DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells. DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage: 50 mg/kg Administration: Oral gavage followed 1 h later by an iron challenge Result: Attenuated the post-challenge serum iron increase. Form:Solid IC50& Target:IC50: 0.83 μM (divalent metal transporter 1)

Names and Identifiers

Smiles	OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4
Molecular Weight	263.29

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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