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DMT-2′O-TBDMS-rA(bz) Phosphoramidite - 97%, high purity , CAS No.104992-55-4

COA

Grade & Purity:

≥97%

Cas Number: 104992-55-4
Molecular Weight: 988.19
PubChem CID: 11355126
PubChem SID: 504766329

In stock

Item Number

B189502

Grouped product items
SKU	Size	Availability	Price
B189502-250mg	250mg	4	$15.90
B189502-1g	1g	4	$48.90
B189502-5g	5g	5	$237.90
B189502-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$428.90

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA Damage (697) DNA Phosphoramidite (17) Nucleoside Antimetabolite/Analog (200)

Basic Description

Synonyms	Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] \| PD158240 \| SCHEMBL667192 \| DMT-2'O-TBDMS-rA(bz) Pharmadite(R) \| N-Benzoyl-5'-O-(4,4-Dimethoxyt
Specifications & Purity	≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques.Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.Key Features Industry-standard 2′O-TBDMS protective group Consistent lot-to-lot purity and performance Compatible with deprotection methods based on methylamine or AMA Standard RNA phosphoramidites provide excellent coupling results whenused with ETT or BTT as an activator; best results are obtained withActivator 42 Capping with standard acetic anhydride capping reagent rather than withFast Deprotection Cap A Manufactured under a certified ISO 9001 quality systemDMT-2′O-TBDMS-rA(bz) Phosphoramidite is configured for MerMade Synthesizers.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Triphenyl compounds

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Triphenyl compounds
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Triphenyl compounds
Alternative Parents	Ribonucleoside phosphoramidites Glycosylamines Benzamides Purines and purine derivatives Benzylethers Anisoles Phenoxy compounds Benzoyl derivatives Methoxybenzenes Alkyl aryl ethers Pyrimidines and pyrimidine derivatives Imidolactams Monosaccharides N-substituted imidazoles Trialkylheterosilanes Oxolanes Heteroaromatic compounds Silyl ethers Secondary carboxylic acid amides Azacyclic compounds Dialkyl ethers Oxacyclic compounds Organic metalloid salts Nitriles Hydrocarbon derivatives Organopnictogen compounds Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Triphenyl compound - Ribonucleoside phosphoramidite - N-glycosyl compound - Glycosyl compound - Benzamide - Purine - Imidazopyrimidine - Benzoic acid or derivatives - Benzylether - Phenoxy compound - Anisole - Phenol ether - Benzoyl - Methoxybenzene - Alkyl aryl ether - Pyrimidine - Monocyclic benzene moiety - Monosaccharide - Imidolactam - N-substituted imidazole - Imidazole - Trialkylheterosilane - Oxolane - Heteroaromatic compound - Azole - Secondary carboxylic acid amide - Silyl ether - Carboxamide group - Organoheterosilane - Oxacycle - Azacycle - Carboxylic acid derivative - Dialkyl ether - Ether - Organic metalloid salt - Organoheterocyclic compound - Carbonitrile - Nitrile - Organopnictogen compound - Cyanide - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organosilicon compound - Organooxygen compound - Organonitrogen compound - Organic metalloid moeity - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504766329
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766329
IUPAC Name	N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide
INCHI	InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
InChIKey	FFXHNCNNHASXCT-RFMFGJHUSA-N
Smiles	CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
Isomeric SMILES	CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
Molecular Weight	988.19
Reaxy-Rn	45611722
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=45611722&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
K2216122	Certificate of Analysis	Aug 02, 2022	B189502
K2216113	Certificate of Analysis	Aug 02, 2022	B189502
K2216115	Certificate of Analysis	Aug 02, 2022	B189502
K2216116	Certificate of Analysis	Aug 02, 2022	B189502
K2216117	Certificate of Analysis	Aug 02, 2022	B189502
K2216114	Certificate of Analysis	Aug 02, 2022	B189502

Chemical and Physical Properties

Molecular Weight	988.200 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	22
Exact Mass	987.448 Da
Monoisotopic Mass	987.448 Da
Topological Polar Surface Area	164.000 Å²
Heavy Atom Count	70
Formal Charge	0
Complexity	1630.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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