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DL-AP7 - ≥97%, high purity , CAS No.78966-69-5

COA COA
    Grade & Purity:
  • ≥97%
  • Cas Number:  78966-69-5
  • Molecular Weight:  225.18
  • Beilstein Registry Number:   3544152
  • PubChem CID: 3122
In stock
Item Number
D335870
Grouped product items
SKU Size
Availability
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D335870-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$52.90
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a potent NMDA receptor antagonist

Basic Description

Synonyms D-200 | Tox21_500008 | (+/-)-2-Amino-7-phosphonoheptanoic acid | AKOS005066193 | MYDMWESTDPJANS-UHFFFAOYSA-N | PDSP2_000129 | DL-2-Amino-7-phosphonoheptanoic acid | (?)-2-Amino-7-phosphonoheptanoic acid | FT-0771861 | BDBM50002363 | A 5157 | HY-100782 | S
Specifications & Purity ≥97%
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

DL-AP7 is a competitive antagonist of the ionotropic glutamate receptor, NMDA. Studies indicate that the S1 and S2 domains of the NMDA receptor are essential in DL-AP7 and other related antagonists to bind to the receptor. In addition, the positively charged Lys residues at the second interaction site and Arg at the fourth site are key factors in ligand binding. The NMDA receptor is unique in that it requires binding of two ligands, glutamate and glycine to become activated. As a result of its inhibitory affects, DL-AP7 is an ideal tool in studying signaling pathways and ion flow through the NMDA receptor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent Alpha amino acids
Alternative Parents Medium-chain fatty acids  Organic phosphonic acids  Amino acids  Monocarboxylic acids and derivatives  Carboxylic acids  Organopnictogen compounds  Organophosphorus compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic acyclic compounds
Substituents Alpha-amino acid - Medium-chain fatty acid - Fatty acyl - Fatty acid - Organophosphonic acid - Organophosphonic acid derivative - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Primary amine - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Amine - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
External Descriptors Not available

Product Properties

pKa pKa: 2.54 (Predicted), pKa: 9.84 (Predicted)
Ki Data Glutamate NMDA receptor: Ki= 912 nM (rat)

Associated Targets(Human)

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIK3 Tclin Glutamate receptor ionotropic kainate 3 (50 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 Activities)
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CAKI-1 (44928 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 Activities)
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PC-3 (62116 Activities)
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RPMI-8226 (44974 Activities)
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RXF 393 (41971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-295 (48000 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
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UACC-257 (46019 Activities)
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UACC-62 (47335 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI/ADR-RES (33767 Activities)
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T47D (39041 Activities)
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EKVX (44102 Activities)
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NCI-H322M (45589 Activities)
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HCC 2998 (41480 Activities)
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HCT-116 (91556 Activities)
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HEK293 (82097 Activities)
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HOP-92 (41141 Activities)
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Hs-578T (29457 Activities)
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NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
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IGROV-1 (47897 Activities)
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LOX IMVI (44321 Activities)
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MDA-MB-435 (38290 Activities)
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MDA-N (28205 Activities)
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Associated Targets(non-human)

Saccharomyces cerevisiae (19171 Activities)
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Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-amino-7-phosphonoheptanoic acid
INCHI InChI=1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)
InChIKey MYDMWESTDPJANS-UHFFFAOYSA-N
Smiles C(CCC(C(=O)O)N)CCP(=O)(O)O
Isomeric SMILES C(CCC(C(=O)O)N)CCP(=O)(O)O
WGK Germany 3
RTECS MJ1927500
Molecular Weight 225.18
Beilstein 3544152
Reaxy-Rn 3544152
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3544152&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Soluble in 1eq. NaOH (100 mM).
Refractive Index n20D1.52 (Predicted)
Boil Point(°C) 480.13° C at 760 mmHg (Predicted)
Melt Point(°C) 222-226° C
Molecular Weight 225.180 g/mol
XLogP3 -3.600
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 7
Exact Mass 225.077 Da
Monoisotopic Mass 225.077 Da
Topological Polar Surface Area 121.000 Ų
Heavy Atom Count 14
Formal Charge 0
Complexity 226.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

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