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DK-AH 269 - ≥98%, high purity , CAS No.186097-54-1

COA

Grade & Purity:

≥98%

Cas Number: 186097-54-1
Molecular Weight: 519.07
PubChem CID: 16078969

In stock

Item Number

D350697

Grouped product items
SKU	Size	Availability	Price
D350697-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$91.90
D350697-5mg	5mg	2	$228.90
D350697-10mg	10mg	2	$342.90
D350697-25mg	25mg	1	$572.90
D350697-50mg	50mg	1	$801.90

an HCN Channel blocker

View related series

HCN Channel (5) Ion channel (2197) Membrane Transporter/Ion Channel (1822)

Basic Description

Synonyms	HY-18940A \| DTXSID10582024 \| DK-AH 269 \| 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride \| DK-AH 269, >=98% (HPLC), solid \| 3-({(3S)-1-[2-(3,4-Dimethoxyphenyl)ethyl]piperidin-3-
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	An HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels. Application： DK-AH 269 has been used as a hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) antagonist to study its effects on the inhibition of Ih in HCN-deficient hair cells of mice.It has also been used as an HCN blocker to study its effects on action potential firing in the suprachiasmatic nucleus (SCN) neurons

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzazepines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzazepines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzazepines
Alternative Parents	Dimethoxybenzenes Phenethylamines Phenoxy compounds Anisoles Alkyl aryl ethers Aralkylamines Azepines Piperidines Tertiary carboxylic acid amides Trialkylamines Lactams Amino acids and derivatives Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Hydrochlorides Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzazepine - Dimethoxybenzene - O-dimethoxybenzene - Phenethylamine - Anisole - Phenoxy compound - Phenol ether - Methoxybenzene - Alkyl aryl ether - Azepine - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Piperidine - Tertiary carboxylic acid amide - Tertiary aliphatic amine - Carboxamide group - Lactam - Amino acid or derivatives - Tertiary amine - Ether - Carboxylic acid derivative - Azacycle - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Organonitrogen compound - Organooxygen compound - Amine - Organic oxide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ring fused to an azepine ring (unsaturated seven-membered heterocycle with one nitrogen atom replacing a carbon atom).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
INCHI	InChI=1S/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31;/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3;1H/t21-;/m0./s1
InChIKey	MTAKUIYCCYKGJJ-BOXHHOBZSA-N
Smiles	COC1=C(C=C(C=C1)CCN2CCCC(C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC.Cl
Isomeric SMILES	COC1=C(C=C(C=C1)CCN2CCC[C@@H](C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC.Cl
WGK Germany	3
Alternate CAS	147541-45-5
Molecular Weight	519.07
Reaxy-Rn	10509461
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10509461&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
E2423285	Certificate of Analysis	Jan 24, 2024	D350697
E2423286	Certificate of Analysis	Jan 24, 2024	D350697
E2423271	Certificate of Analysis	Jan 24, 2024	D350697
E2423274	Certificate of Analysis	Jan 24, 2024	D350697
E2423267	Certificate of Analysis	Jan 24, 2024	D350697
E2423269	Certificate of Analysis	Jan 24, 2024	D350697
E2423276	Certificate of Analysis	Jan 24, 2024	D350697
E2423278	Certificate of Analysis	Jan 24, 2024	D350697
E2423280	Certificate of Analysis	Jan 24, 2024	D350697
E2423282	Certificate of Analysis	Jan 24, 2024	D350697

Chemical and Physical Properties

Solubility	Soluble in water (20 mg/ml).
Sensitivity	Moisture Sensitive
Molecular Weight	519.100 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	518.255 Da
Monoisotopic Mass	518.255 Da
Topological Polar Surface Area	60.500 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	663.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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