Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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D129205-1g
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1g |
3
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$9.90
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D129205-5g
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5g |
3
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$38.90
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D129205-10g
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10g |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$68.90
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D129205-25g
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25g |
3
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$114.90
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D129205-100g
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100g |
2
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$413.90
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Non-selective phosphodiesterase (PDE) inhibitor
| Synonyms | (3E)-3-[[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]methylene]dihydro-5-methoxy-2(3H)3-[(1E)-2-[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethenyl]furan; (+)-Coronarin E-furanone; Coronarin D methyl ethe | D |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | Dipyridamole is a PDE (phosphodiesterase) inhibitor with antioxidant properties. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis. Research indicat |
| Storage Temp | Protected from light,Store at -20°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | 3',5'-cyclic phosphodiesterase inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic nitrogen compounds |
| Class | Organonitrogen compounds |
| Subclass | Amines |
| Intermediate Tree Nodes | Tertiary amines - Tertiary alkylarylamines |
| Direct Parent | Dialkylarylamines |
| Alternative Parents | Aminopyrimidines and derivatives Piperidines Imidolactams Heteroaromatic compounds Azacyclic compounds Alkanolamines Primary alcohols Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Dialkylarylamine - Aminopyrimidine - Piperidine - Pyrimidine - Imidolactam - Heteroaromatic compound - Organoheterocyclic compound - Alkanolamine - Azacycle - Alcohol - Hydrocarbon derivative - Primary alcohol - Organopnictogen compound - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group. |
| External Descriptors | piperidines - tertiary amino compound - tetrol - pyrimidopyrimidine |
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| ALogP | 0.7 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504750638 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750638 |
| IUPAC Name | 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol |
| INCHI | InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 |
| InChIKey | IZEKFCXSFNUWAM-UHFFFAOYSA-N |
| Smiles | C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO |
| Isomeric SMILES | C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO |
| WGK Germany | 2 |
| RTECS | KK7450000 |
| Molecular Weight | 504.63 |
| Beilstein | 26(3/4)3840 |
| Reaxy-Rn | 68373 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=68373&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 20, 2024 | D129205 | |
| Certificate of Analysis | May 20, 2024 | D129205 | |
| Certificate of Analysis | May 12, 2023 | D129205 | |
| Certificate of Analysis | May 12, 2023 | D129205 | |
| Certificate of Analysis | Apr 10, 2023 | D129205 | |
| Certificate of Analysis | Jun 17, 2022 | D129205 | |
| Certificate of Analysis | Aug 16, 2021 | D129205 |
| Solubility | Soluble in chloroform, methanol, dilute acids, ethanol (10 mM), DMSO (100 mM), and water (slightly soluble). |
|---|---|
| Sensitivity | light sensitive |
| Melt Point(°C) | 165-166°C |
| Molecular Weight | 504.600 g/mol |
| XLogP3 | 0.700 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 12 |
| Exact Mass | 504.317 Da |
| Monoisotopic Mass | 504.317 Da |
| Topological Polar Surface Area | 145.000 Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 561.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng. (2019) Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, |
| 2. Jiaying Song, Xingyi Li, Kailibinuer Abuduwaili, Yue Sun, Jiangbo Li, Danying Chen, Zhuofan Chen, Zhipeng Li, Baoxin Huang. (2025) Dipyridamole Attenuates Experimental Periodontitis by Regulating M1 Macrophage Polarization via PKA/PKG Pathways. JOURNAL OF PERIODONTAL RESEARCH, |
| 3. Mengru Bai, Qian Shen, Yong Wu, Zhiyuan Ma, Yuqing Wang, Mingyang Chen, Dan Liu, Lin Zhou. (2024) Evaluation of transport mechanisms of methotrexate in human choriocarcinoma cell lines by LC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 247 (116268). |