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Dihydrorhodamine 123, CAS No.109244-58-8

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Dihydrorhodamine 123, CAS No.109244-58-8

14 Citations

COA

Grade & Purity:

Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite.

In stock

Item Number

D755415

Grouped product items
SKU	Size	Availability	Price	Qty
D755415-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$414.90

Basic Description

Product Name	Dihydrorhodamine 123, CAS No.109244-58-8
Product Description	Cell-permeable fluorogenic probe that is useful for detection of reactive oxygen species (ROS), such as peroxide and peroxynitrite. Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite. Dihydrorhodamine is not fluorescent unless it is converted to rhodamine 123.
Specifications & Purity	Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite.
Biochemical and Physiological Mechanisms	Cell permeable: yesPrimary TargetDetection of reactive oxygen species (ROS)Product does not compete with ATP.Reversible: no

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzopyrans
    - Subclass 1-benzopyrans
      - Level5 Dibenzopyrans
        Level6 Xanthenes

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzopyrans
Subclass	1-benzopyrans
Intermediate Tree Nodes	Dibenzopyrans
Direct Parent	Xanthenes
Alternative Parents	Diarylethers Benzoic acid esters Benzoyl derivatives Methyl esters Amino acids and derivatives Oxacyclic compounds Monocarboxylic acids and derivatives Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Xanthene - Diaryl ether - Benzoate ester - Benzoic acid or derivatives - Benzoyl - Monocyclic benzene moiety - Benzenoid - Methyl ester - Amino acid or derivatives - Carboxylic acid ester - Carboxylic acid derivative - Oxacycle - Ether - Monocarboxylic acid or derivatives - Primary amine - Organic nitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Storage and Shipping

Concentration	Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
CAS	109244-58-8

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Zekun Gao, Xiuli Zheng, Xiangyu Dong, Weimin Liu, Jie Sha, Shuaishuai Bian, Jian Li, Huan Cong, Chun-Sing Lee, Pengfei Wang. (2024) A General Strategy for Enhanced Photodynamic Antimicrobial Therapy with Perylenequinonoid Photosensitizers Using a Macrocyclic Supramolecular Carrier. Advanced Healthcare Materials, (2401778).
2. Zhencheng Sun, Jiaxin Wang, Minghui Xiao, Kaiyu Wu, Cheng Wang, Hao Fu, Shuyi Lv, Linqi Shi, Chunlei Zhu. (2024) A straightforward strategy to modulate ROS generation of AIE photosensitizers for type-I PDT. CHEMICAL ENGINEERING JOURNAL, (155782).
3. Edward Kamya, Shangzhao Yi, Zhongzhong Lu, Jincong Yan, Hewan Dawit, Shah Mehmood, Yi Cao, Renjun Pei. (2025) AIE Photosensitizer with Tuned Membrane Interactions for Effective-Gram-Negative Bacteria Elimination. BIOCONJUGATE CHEMISTRY,
4. Qi Yang, Han Yeong Kaw, Jing Yu, Xuejing Ma, Kun Yang, Lizhong Zhu, Wei Wang. (2025) Basic Nitrogenous Heterocyclic Rings at the 7-Position of Fluoroquinolones Foster Their Induction of Antibiotic Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 59 (13): (6787-6798).
5. Li Wei, Rajesh Kushwaha, Tumpa Sadhukhan, Haorui Wu, Anyi Dao, Zhishang Zhang, Haotu Zhu, Qiufang Gong, Jiaxi Ru, Chao Liang, Pingyu Zhang, Samya Banerjee, Huaiyi Huang. (2024) Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity. JOURNAL OF MEDICINAL CHEMISTRY, 67 (13): (11125-11137).
6. Dejia Chen, Yixuan Xu, Yating Wang, Xin Li, Dalong Yin, Lifeng Yan. (2024) Diradicaloid-Loaded Polypeptide Nanoparticles for Two-Photon NIR Phototheranostics. ACS Applied Materials & Interfaces, 16 (44): (59907-59920).
7. Zhongyu Wang, Li Wei, Junfeng Lin, Can Huang, Huitong Chen, Dong Fan, Weiyu Hu, Jing Liu, Huaiyi Huang, Zongming Wang, Xin Wang. (2024) Donor–Acceptor–Donor Strategy Rouses the Photodynamic Therapy Anticancer Activity of a Bis-terpyridyl Ru(II) Complex. JOURNAL OF MEDICINAL CHEMISTRY, 67 (15): (13435-13445).
8. Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang. (2025) IR783-Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation. Advanced Science, (2415684).
9. Meiying Liu, Tongsheng Huang, Yiping Liu, Lihua Chen, Shijie Liao, Xinxin Gong, Mubarak G. Bello, Weifeng Zhu, Shaorong Huang, Xiaoyong Zhang. (2025) Loading curcumin on hyperbranched polymers functionalized Zein via the phenol-yne click reaction as pH-responsive drug delivery system for chemotherapy and photodynamic therapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (139750).
10. Mingdi Yang, Kaiwen Li, Liangchen Zhong, Yingcui Bu, Yingyong Ni, Ting Wang, Jing Huang, Jingyan Zhang, Hongping Zhou. (2024) Molecular engineering to elevate reactive oxygen species generation for synergetic damage on lipid droplets and mitochondria. ANALYTICA CHIMICA ACTA, 1311 (342734).
11. Xianjiao Tang, Liping Chen, Yuhan Wang, Pengwei Chen, Lin-Song Li, Xiaojing Yang, Mei-Xia Zhao. (2024) Multimodal phototherapy agents target lipid droplets for near-infrared imaging-guided type I photodynamic/photothermal therapy. Acta Biomaterialia,
12. Tianyu Zhu, Jipeng Ding, Fan Zheng, Yanpeng Fang, Wenzhi Huang, Ying Yin, Wenbin Zeng. (2025) Synergistic Cancer Therapy: An NIR-Activated Methylene Blue-Nitrogen Mustard Prodrug for Combined Chemotherapy and Photodynamic Therapy. JOURNAL OF MEDICINAL CHEMISTRY, 68 (7): (7630-7641).
13. Jizhong Shi, Manshan Liang, Yiting Qiu, Jin Zhang, Shihua Wang, Heng Fang, Yongsheng Jiang, Xiaoxia Ye, Yanshu Luo, Zu-Sheng Huang, Yun-Yun Quan. (2025) Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy. TALANTA, 282 (127074).
14. Kun Zhang, Weirong Kong, Dewu Lin, Xiaobing Wang, Pan Wang. (2025) Ultrasound-Driven Nitric Oxide Generation for Enhanced Sonodynamic–Photothermal Therapy. MOLECULAR PHARMACEUTICS,

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