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Dihydrorhodamine 123 - 95%, high purity , CAS No.109244-58-8

24 Citations COA COA
    Grade & Purity:
  • ≥95%
In stock
Item Number
D115501
Grouped product items
SKU Size
Availability
 Price Qty
D115501-1mg
1mg
3
$48.90
D115501-5mg
5mg
3
$117.90
D115501-10mg
10mg
2
$212.90
D115501-25mg
25mg
1
$477.90
D115501-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,338.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Fluorescent Dye (372)

Basic Description

Synonyms AKOS015894985 | Methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate | dihydrorhodamine-123 | FT-0624967 | C21H18N2O3 | MFCD04221428 | A11886 | DHR 123 | DTXSID40148859 | HY-101894 | SCHEMBL3682802 | J-100130 | Benzoic acid, 2-(3,6-diamino-9H-xanthen-9-yl)-, me
Specifications & Purity ≥95%
Biochemical and Physiological Mechanisms 二氢罗丹明123可检测单细胞水平的超氧离子 可用于在呼吸爆发事件中探测中性粒细胞超氧化物的产生。也用于检测巨噬细胞和人类精子的氧化应激情况。 二氢罗丹明123可用于检测ROS（活性氧物质）。ROS的存在可将二氢罗丹明123氧化成荧光衍生物罗丹明123。该反应可在过氧化物酶或类似催化剂存在下发生。
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Peroxidase substrate

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzopyrans
Subclass 1-benzopyrans
Intermediate Tree Nodes Dibenzopyrans
Direct Parent Xanthenes
Alternative Parents Diarylethers  Benzoic acid esters  Benzoyl derivatives  Methyl esters  Amino acids and derivatives  Oxacyclic compounds  Monocarboxylic acids and derivatives  Primary amines  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Xanthene - Diaryl ether - Benzoate ester - Benzoic acid or derivatives - Benzoyl - Monocyclic benzene moiety - Benzenoid - Methyl ester - Amino acid or derivatives - Carboxylic acid ester - Carboxylic acid derivative - Oxacycle - Ether - Monocarboxylic acid or derivatives - Primary amine - Organic nitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
External Descriptors Not available

Names and Identifiers

Pubchem Sid 504756596
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504756596
IUPAC Name methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate
INCHI InChI=1S/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3
InChIKey FNEZBBILNYNQGC-UHFFFAOYSA-N
Smiles COC(=O)C1=CC=CC=C1C2C3=C(C=C(C=C3)N)OC4=C2C=CC(=C4)N
Isomeric SMILES COC(=O)C1=CC=CC=C1C2C3=C(C=C(C=C3)N)OC4=C2C=CC(=C4)N
WGK Germany 3
Molecular Weight 346.38
Reaxy-Rn 5989965
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5989965&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot Number Certificate Type Date Item
C2513331 Certificate of Analysis Feb 05, 2025 D115501
C2519040 Certificate of Analysis Feb 05, 2025 D115501
C2513327 Certificate of Analysis Feb 05, 2025 D115501
C2513329 Certificate of Analysis Feb 05, 2025 D115501
C2513347 Certificate of Analysis Feb 05, 2025 D115501
C2513353 Certificate of Analysis Feb 05, 2025 D115501
F2406453 Certificate of Analysis May 06, 2024 D115501
F2406450 Certificate of Analysis May 06, 2024 D115501
F2406455 Certificate of Analysis May 06, 2024 D115501
H2328629 Certificate of Analysis Aug 11, 2023 D115501
H2328710 Certificate of Analysis Aug 11, 2023 D115501
H2328709 Certificate of Analysis Aug 11, 2023 D115501
H2328708 Certificate of Analysis Aug 11, 2023 D115501
H2328630 Certificate of Analysis Aug 11, 2023 D115501
D2411046 Certificate of Analysis Aug 11, 2023 D115501
H2328656 Certificate of Analysis Aug 11, 2023 D115501
H2328631 Certificate of Analysis Aug 11, 2023 D115501
H2328632 Certificate of Analysis Aug 11, 2023 D115501
B23111019 Certificate of Analysis Jan 29, 2023 D115501
B2311715 Certificate of Analysis Jan 29, 2023 D115501
B2311564 Certificate of Analysis Jan 29, 2023 D115501

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Chemical and Physical Properties

Solubility DMSO: >5 mg/mL
Sensitivity Light sensitive
Molecular Weight 346.400 g/mol
XLogP3 3.400
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 3
Exact Mass 346.132 Da
Monoisotopic Mass 346.132 Da
Topological Polar Surface Area 87.600 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 487.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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    Rhodamine 123
    • 10mM in DMSO

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  2. no_selection
    Rhodamine 123
    • ≥98%

    Starting at $64.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Tongsheng Huang, Xin Hu, Shiyu Huang, Dong Liu, Lihua Chen, Qinghua Wu, Weifeng Zhu, Xiaoyong Zhang, Meiying Liu, Yen Wei.  (2024)  One-step synthesis of cyclodextrin-based fluorescent hyperbranched polymer as type I photosensitizer for effective photodynamic therapy.  DYES AND PIGMENTS,  223  (111928). 
2. Liying Pan, Shihua Wang, Mintao Xie, Manshan Liang, Lichao Yu, Bing Du, Xiaoxia Ye, Yanshu Luo, Yun-Yun Quan, Zu-Sheng Huang.  (2023)  Biotin receptor and mitochondria dual targeted AIE photosensitizer for fluorescence imaging guided photodynamic anticancer therapy.  MATERIALS & DESIGN,  235  (112441). 
3. Qingchen Bai, Miao Wang, Jingwei Liu, Xilin Sun, Piaoping Yang, Fengyu Qu, Huiming Lin.  (2023)  Porous Molybdenum Nitride Nanosphere as Carrier-Free and Efficient Nitric Oxide Donor for Synergistic Nitric Oxide and Chemo/Sonodynamic Therapy.  ACS Nano,  17  (20): (20098–20111). 
4. Zhishang Zhang, Wenqing Li, Haorui Wu, Zhuangfeng Liu, Huaiyi Huang.  (2023)  Novel photoactivated Indole–pyridine chemotherapeutics with strong antimicrobial and antibiofilm activity toward Staphylococcus aureus.  BIOORGANIC CHEMISTRY,  140  (106813). 
5. Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan.  (2024)  Highly bright stable organic radicals encapsulated by amphiphilic polypeptide for efficient near-infrared phototheranostics.  TALANTA,  266  (124948). 
6. Ke Xue, Yongfei Zhao, Saidong Sun, Yuanhang Li, Jiankang Liang, Zhengjian Qi.  (2023)  NIR-AIEgens nanospheres featuring high-fidelity dynamic lipid droplet targeting, expediting ferroptosis to annihilating tumor in hypoxia.  CHEMICAL ENGINEERING JOURNAL,  470  (144125). 
7. Chaojie Shen, Mintao Xie, Liying Pan, Binbin Wu, Wenxuan Zhang, Yuying Yuan, Yuan Chen, Yun-Yun Quan, Xiaoxia Ye, Zu-Sheng Huang.  (2023)  Acceptor substitution engineering of BODIPY-based organic photosensitizers with aggregation-induced emission for organelle localization and photodynamic anticancer therapy.  MATERIALS & DESIGN,  228  (111838). 
8. Jing Ruan, Fang Li, Hao Tian, Jie Yu, Hongpei Deng, Shengfang Ge, Kam W. Leong.  (2022)  A cascade FRET photosensitizer that enhances photodynamic therapy for ocular melanoma.  Nano Today,  47  (101684). 
9. Hengrui Zhang, Wenya Jiang, Yaou Peng, Jie Yang, Xiaoying Chu, Ziyue Long, Renlong Li, Qiuwei Liang, Hao Suo, Shuting Wang, Mei Yang, Ji Qi, Dan Ding, Ying-Wei Yang, Bailiang Wang.  (2022)  Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis.  BIOMATERIALS,  286  (121577). 
10. Xueyan Ren, Peipei An, Xin Zhai, Shuo Wang, Qingjun Kong.  (2019)  The antibacterial mechanism of pterostilbene derived from xinjiang wine grape: A novel apoptosis inducer in Staphyloccocus aureus and Escherichia coli.  LWT-FOOD SCIENCE AND TECHNOLOGY,  101  (100). 
11. Zekun Gao, Xiuli Zheng, Xiangyu Dong, Weimin Liu, Jie Sha, Shuaishuai Bian, Jian Li, Huan Cong, Chun-Sing Lee, Pengfei Wang.  (2024)  A General Strategy for Enhanced Photodynamic Antimicrobial Therapy with Perylenequinonoid Photosensitizers Using a Macrocyclic Supramolecular Carrier.  Advanced Healthcare Materials,    (2401778). 
12. Zhencheng Sun, Jiaxin Wang, Minghui Xiao, Kaiyu Wu, Cheng Wang, Hao Fu, Shuyi Lv, Linqi Shi, Chunlei Zhu.  (2024)  A straightforward strategy to modulate ROS generation of AIE photosensitizers for type-I PDT.  CHEMICAL ENGINEERING JOURNAL,    (155782). 
13. Edward Kamya, Shangzhao Yi, Zhongzhong Lu, Jincong Yan, Hewan Dawit, Shah Mehmood, Yi Cao, Renjun Pei.  (2025)  AIE Photosensitizer with Tuned Membrane Interactions for Effective-Gram-Negative Bacteria Elimination.  BIOCONJUGATE CHEMISTRY,     
14. Qi Yang, Han Yeong Kaw, Jing Yu, Xuejing Ma, Kun Yang, Lizhong Zhu, Wei Wang.  (2025)  Basic Nitrogenous Heterocyclic Rings at the 7-Position of Fluoroquinolones Foster Their Induction of Antibiotic Resistance in Escherichia coli.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  59  (13): (6787-6798). 
15. Li Wei, Rajesh Kushwaha, Tumpa Sadhukhan, Haorui Wu, Anyi Dao, Zhishang Zhang, Haotu Zhu, Qiufang Gong, Jiaxi Ru, Chao Liang, Pingyu Zhang, Samya Banerjee, Huaiyi Huang.  (2024)  Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity.  JOURNAL OF MEDICINAL CHEMISTRY,  67  (13): (11125-11137). 
16. Dejia Chen, Yixuan Xu, Yating Wang, Xin Li, Dalong Yin, Lifeng Yan.  (2024)  Diradicaloid-Loaded Polypeptide Nanoparticles for Two-Photon NIR Phototheranostics.  ACS Applied Materials & Interfaces,  16  (44): (59907-59920). 
17. Zhongyu Wang, Li Wei, Junfeng Lin, Can Huang, Huitong Chen, Dong Fan, Weiyu Hu, Jing Liu, Huaiyi Huang, Zongming Wang, Xin Wang.  (2024)  Donor–Acceptor–Donor Strategy Rouses the Photodynamic Therapy Anticancer Activity of a Bis-terpyridyl Ru(II) Complex.  JOURNAL OF MEDICINAL CHEMISTRY,  67  (15): (13435-13445). 
18. Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang.  (2025)  IR783-Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation.  Advanced Science,    (2415684). 
19. Meiying Liu, Tongsheng Huang, Yiping Liu, Lihua Chen, Shijie Liao, Xinxin Gong, Mubarak G. Bello, Weifeng Zhu, Shaorong Huang, Xiaoyong Zhang.  (2025)  Loading curcumin on hyperbranched polymers functionalized Zein via the phenol-yne click reaction as pH-responsive drug delivery system for chemotherapy and photodynamic therapy.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (139750). 
20. Mingdi Yang, Kaiwen Li, Liangchen Zhong, Yingcui Bu, Yingyong Ni, Ting Wang, Jing Huang, Jingyan Zhang, Hongping Zhou.  (2024)  Molecular engineering to elevate reactive oxygen species generation for synergetic damage on lipid droplets and mitochondria.  ANALYTICA CHIMICA ACTA,  1311  (342734). 
21. Xianjiao Tang, Liping Chen, Yuhan Wang, Pengwei Chen, Lin-Song Li, Xiaojing Yang, Mei-Xia Zhao.  (2024)  Multimodal phototherapy agents target lipid droplets for near-infrared imaging-guided type I photodynamic/photothermal therapy.  Acta Biomaterialia,     
22. Tianyu Zhu, Jipeng Ding, Fan Zheng, Yanpeng Fang, Wenzhi Huang, Ying Yin, Wenbin Zeng.  (2025)  Synergistic Cancer Therapy: An NIR-Activated Methylene Blue-Nitrogen Mustard Prodrug for Combined Chemotherapy and Photodynamic Therapy.  JOURNAL OF MEDICINAL CHEMISTRY,  68  (7): (7630-7641). 
23. Jizhong Shi, Manshan Liang, Yiting Qiu, Jin Zhang, Shihua Wang, Heng Fang, Yongsheng Jiang, Xiaoxia Ye, Yanshu Luo, Zu-Sheng Huang, Yun-Yun Quan.  (2025)  Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy.  TALANTA,  282  (127074). 
24. Kun Zhang, Weirong Kong, Dewu Lin, Xiaobing Wang, Pan Wang.  (2025)  Ultrasound-Driven Nitric Oxide Generation for Enhanced Sonodynamic–Photothermal Therapy.  MOLECULAR PHARMACEUTICS,     

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