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Difluoromethylornithine - ≥98%, high purity , CAS No.66640-93-5

    Grade & Purity:
  • ≥98%
In stock
Item Number
D275915
Grouped product items
SKU Size
Availability
Price Qty
D275915-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$80.90
D275915-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90

Irreversible ornithine decarboxylase inhibitor

Basic Description

Synonyms (S)-eflornithine | 66640-93-5 (L-isomer) | C780YUS9YI | L-EFLORNITHINE | L-DFMO | HY-B0744C | (+)-alpha-difluoromethylornithine | (2S)-2,5-diamino-2-(difluoromethyl)pentanoic acid | AKOS030607731 | L-RMI71782 | BIDD:GT0723 | EFLORNITHINE, (S)- | (S)-2,5-d
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Potent, irreversible ornithine decarboxylase inhibitor (K i = 39 μM). Depletes polyamines in vitro . Antineoplastic, cytotoxic and trypanocidal agent. Orally active. Active in vivo and in vitro .
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct Parent L-alpha-amino acids
Alternative Parents D-alpha-amino acids  Halogenated fatty acids  Branched fatty acids  Amino acids  Monocarboxylic acids and derivatives  Carboxylic acids  Organopnictogen compounds  Organofluorides  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  Alkyl fluorides  
Molecular Framework Aliphatic acyclic compounds
Substituents D-alpha-amino acid - L-alpha-amino acid - Branched fatty acid - Halogenated fatty acid - Fatty acid - Fatty acyl - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Amine - Alkyl halide - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors Not available

Associated Targets(Human)

ODC1 Tclin Ornithine decarboxylase (70 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Trypanosoma brucei (78846 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei gambiense (523 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2S)-2,5-diamino-2-(difluoromethyl)pentanoic acid
INCHI InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)/t6-/m1/s1
InChIKey VLCYCQAOQCDTCN-ZCFIWIBFSA-N
Smiles C(CC(C(F)F)(C(=O)O)N)CN
Isomeric SMILES C(C[C@@](C(F)F)(C(=O)O)N)CN
Reaxy-Rn 2250529
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2250529&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Soluble in water
Molecular Weight 182.170 g/mol
XLogP3 -2.900
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 5
Exact Mass 182.087 Da
Monoisotopic Mass 182.087 Da
Topological Polar Surface Area 89.300 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 166.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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