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Dexrazoxane HCl (ICRF-187, ADR-529) - ≥99%, high purity , CAS No.149003-01-0

    Grade & Purity:
  • ≥99%
In stock
Item Number
D129340
Grouped product items
SKU Size
Availability
Price Qty
D129340-10mg
10mg
3
$58.90
D129340-50mg
50mg
3
$111.90
D129340-250mg
250mg
3
$504.90

Topoisomerase II inhibitor. Intracellular ion chelator.

Basic Description

Synonyms p,p-Methoxychlor olefin | Q27121988 | Dexrazoxane HCl (ICRF-187, ADR-529) | Dexrazoxane for Injection | TopoTect | Cardioxane hydrochloride | D07807 | Dexrazoxane hydrochloride [ORANGE BOOK] | ICRF 187 hydrochloride | UNII-5346058Q7S | 4,4'-(2S)-propane-1
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Dexrazoxane hydrochloride is a cardioprotective agent. As a derivative of EDTA, dexrazoxane chelates iron, thus reduce the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. This agent is us
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Dexrazoxane HCl(ICRF-187, ADR-529) is a cardioprotective agent.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives
Direct Parent Alpha amino acids and derivatives
Alternative Parents Dioxopiperazines  N-alkylpiperazines  N-unsubstituted carboxylic acid imides  Dicarboximides  Trialkylamines  Azacyclic compounds  Organopnictogen compounds  Organic zwitterions  Organic oxides  Organic chloride salts  Hydrochlorides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents Alpha-amino acid or derivatives - Dioxopiperazine - N-alkylpiperazine - 1,4-diazinane - Piperazine - Carboxylic acid imide - Dicarboximide - Carboxylic acid imide, n-unsubstituted - Tertiary amine - Tertiary aliphatic amine - Azacycle - Organoheterocyclic compound - Organic zwitterion - Hydrochloride - Organic nitrogen compound - Organic chloride salt - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Amine - Organic salt - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors hydrochloride

Associated Targets(Human)

ENGASE Tchem Endo-beta-N-acetylglucosaminidase (63 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764353
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764353
IUPAC Name 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride
INCHI InChI=1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1
InChIKey BIFMNMPSIYHKDN-FJXQXJEOSA-N
Smiles CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
Isomeric SMILES C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
Alternate CAS 1263283-43-7
Molecular Weight 304.73

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
F1509068 Certificate of Analysis Jan 19, 2023 D129340
C2223233 Certificate of Analysis May 03, 2022 D129340
C2223229 Certificate of Analysis May 03, 2022 D129340
C2223352 Certificate of Analysis May 03, 2022 D129340

Chemical and Physical Properties

Solubility DMSO 61 mg/mL Water 61 mg/mL Ethanol <1 mg/mL
Molecular Weight 304.730 g/mol
XLogP3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 3
Exact Mass 304.094 Da
Monoisotopic Mass 304.094 Da
Topological Polar Surface Area 98.800 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 404.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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