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Dexamethasone 21-phosphate disodium salt - 10mM in Water, high purity , CAS No.2392-39-4, Glucocorticoid receptor agonist
Potent glucocorticoid receptor agonist. Dexamethasone prodrug.
Basic Description
Synonyms
DEXAMETHASONE SODIUM PHOSPHATE | 2392-39-4 | Dexamethasone 21-phosphate disodium salt | Dalalone | Dexadreson | Dexagro | Megacort | Soldesam | Dexamethasone disodium phosphate | 55203-24-2 | Decadron phosphate | Dexabene | Spersadox | Decdan | Solu-Decadron | Ak-Dex | Colvasone | Dexagel
Specifications & Purity
10mM in Water
Biochemical and Physiological Mechanisms
Potent glucocorticoid receptor agonist and dexamethasone prodrug. Multiple effects on cell survival, cell signaling and gene expression. Anti-inflammatory and immunosupressant. Active in vivo.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
AGONIST
Mechanism of action
Glucocorticoid receptor agonist
Product Description
Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Subclass
Pregnane steroids
Intermediate Tree Nodes
Not available
Direct Parent
Gluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
20-oxosteroids 11-beta-hydroxysteroids 17-hydroxysteroids 3-oxo delta-1,4-steroids Halogenated steroids Delta-1,4-steroids Glycerone phosphates Alkyl phosphates Tertiary alcohols Alpha-hydroxy ketones Secondary alcohols Cyclic alcohols and derivatives Cyclic ketones Fluorohydrins Organic metal halides Alkyl fluorides Hydrocarbon derivatives Organofluorides Organic sodium salts Organic oxides
Molecular Framework
Aliphatic homopolycyclic compounds
Substituents
Progestogin-skeleton - 20-oxosteroid - 3-oxo-delta-1,4-steroid - 3-oxosteroid - 9-halo-steroid - Halo-steroid - Hydroxysteroid - Oxosteroid - 11-beta-hydroxysteroid - 11-hydroxysteroid - 17-hydroxysteroid - Delta-1,4-steroid - Glycerone phosphate - Alkyl phosphate - Phosphoric acid ester - Organic phosphoric acid derivative - Tertiary alcohol - Alpha-hydroxy ketone - Cyclic alcohol - Secondary alcohol - Cyclic ketone - Fluorohydrin - Ketone - Halohydrin - Organic metal halide - Organic alkali metal salt - Hydrocarbon derivative - Organic oxide - Organohalogen compound - Organic oxygen compound - Organofluoride - Carbonyl group - Organooxygen compound - Alkyl halide - Alkyl fluoride - Alcohol - Organic salt - Organic sodium salt - Aliphatic homopolycyclic compound
Description
This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
External Descriptors
organic sodium salt
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
INCHI
InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
InChIKey
PLCQGRYPOISRTQ-FCJDYXGNSA-L
Smiles
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
Isomeric SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
WGK Germany
3
RTECS
TU4056000
Molecular Weight
516.41
Beilstein
6473066
Reaxy-Rn
29316793
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29316793&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Moisture sensitive，heat sensitive
Melt Point(°C)
235 °C
Molecular Weight
516.400 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Rotatable Bond Count
3
Exact Mass
516.13 Da
Monoisotopic Mass
516.13 Da
Topological Polar Surface Area
147.000 Ų
Heavy Atom Count
34
Formal Charge
0
Complexity
961.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
8
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
3
Citations of This Product
1.
Yu Qiao, Guoqiang Fan, Jun Guo, Shixing Gao, Ruqian Zhao, Xiaojing Yang.
(2019)
Effects of adipokine zinc-α2-glycoprotein on adipose tissue metabolism after dexamethasone treatment. Applied Physiology Nutrition and Metabolism,
44
(1):
2.
Muqing Xu, Dong Ma, Dongxiu Chen, Jieqing Cai, Qiaofang He, Fan Shu, Jie Tang, Hongzheng Zhang.
(2018)
Preparation, characterization and application research of a sustained dexamethasone releasing electrode coating for cochlear implantation. Materials Science & Engineering C-Materials for Biological Applications,
90
(16).
3.
Xiong Liu, Xiangjun Ou, Tiantian Zhang, Xiaonan Li, Qi Qiao, Liyuan Jia, Zhangxi Xu, Fangming Zhang, Tianyi Tian, Hongbing Lan, Conglian Yang, Li Kong, Zhiping Zhang.
(2024)
In situ neutrophil apoptosis and macrophage efferocytosis mediated by Glycyrrhiza protein nanoparticles for acute inflammation therapy. JOURNAL OF CONTROLLED RELEASE,
369
(215).
4.
Chen Liang, Yexuan Guo, Rui Xue Zhang, Hong Yan.
(2024)
Microtubular and high porosity design of electrospun PEGylated poly (lactic-co-glycolic acid) fibrous implant for ocular multi-route administration and medication. INTERNATIONAL JOURNAL OF PHARMACEUTICS,
665
(124751).
5.
Pan Liu, Jiezhong Deng, Yusheng Yang, Wenxi Bai, Shengtao Dong, Zehua Zhang.
(2025)
Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling. iScience,
28
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5 Citations