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Deoxypodophyllotoxin - 99%, high purity , CAS No.19186-35-7

COA COA
In stock
Item Number
D651721
Grouped product items
SKU Size
Availability
 Price Qty
D651721-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$16.90
D651721-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
D651721-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$113.90
D651721-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
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Phenylpropanoids Lignans

View related series
Apoptosis (4276) Autophagy (1917) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Cytoskeleton (498) Microtubule/Tubulin (199) Phenylpropanoids Lignans (15)

Basic Description

Synonyms AC-34638 | Anthricin | F82121 | (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one | (-)-Anthricin | 5,8,8a,9,-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)
Specifications & Purity Moligand™, ≥99%
Biochemical and Physiological Mechanisms Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells Dosage: 5, 10, and 20 mg/kg Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days Result: Inhibited the growth of gastric cancer tumors.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lignans, neolignans and related compounds
Class Lignan lactones
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Lignan lactones
Alternative Parents Aryltetralin lignans  Furanonaphthodioxoles  Tetralins  Benzodioxoles  Phenoxy compounds  Anisoles  Methoxybenzenes  Alkyl aryl ethers  Gamma butyrolactones  Tetrahydrofurans  Carboxylic acid esters  Monocarboxylic acids and derivatives  Oxacyclic compounds  Acetals  Hydrocarbon derivatives  Carbonyl compounds  Organic oxides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Lignan lactone - 1-aryltetralin lignan - Linear furanonaphthodioxole - Naphthofuran - Tetralin - Benzodioxole - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Gamma butyrolactone - Benzenoid - Tetrahydrofuran - Lactone - Carboxylic acid ester - Acetal - Oxacycle - Carboxylic acid derivative - Organoheterocyclic compound - Ether - Monocarboxylic acid or derivatives - Carbonyl group - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as lignan lactones. These are lignans that contain a lactone moiety. They include 1-aryltetralin lactones, dibenzylbutyrolactone lignans, and podophyllotoxins, among others.
External Descriptors Lignans

Associated Targets(Human)

ODC1 Tclin Ornithine decarboxylase (70 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A498 (42825 Activities)
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ACHN (49357 Activities)
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BXPC-3 (2997 Activities)
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CAKI-1 (44928 Activities)
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CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
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DLD-1 (17511 Activities)
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DMS-273 (14108 Activities)
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DU-145 (51482 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MCF7 (126967 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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PC-3 (62116 Activities)
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RPMI-8226 (44974 Activities)
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RXF 393 (41971 Activities)
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SF-295 (48000 Activities)
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SiHa (2051 Activities)
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SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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SNB-78 (14240 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
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UACC-257 (46019 Activities)
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UACC-62 (47335 Activities)
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UO-31 (46270 Activities)
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XF498 (12972 Activities)
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ZR-75-1 (953 Activities)
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786-0 (47912 Activities)
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A549 (127892 Activities)
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NCI/ADR-RES (33767 Activities)
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T47D (39041 Activities)
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Col2 (437 Activities)
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EKVX (44102 Activities)
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A-431 (6446 Activities)
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GLC4 cell line (37 Activities)
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NCI-H322M (45589 Activities)
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Associated Targets(non-human)

Neisseria gonorrhoeae (1461 Activities)
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Candida albicans (78123 Activities)
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Artemia (698 Activities)
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Mus musculus (284745 Activities)
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Human alphaherpesvirus 1 (11089 Activities)
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Measles morbillivirus (693 Activities)
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Vesicular stomatitis virus (4460 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CV-1 (316 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P388 (20296 Activities)
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P388/ADR (1216 Activities)
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Vero (26788 Activities)
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TUBB2B Tubulin (2175 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
INCHI InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1
InChIKey ZGLXUQQMLLIKAN-SVIJTADQSA-N
Smiles COC1=CC(=CC(=C1OC)OC)C2C3C(CC4=CC5=C(C=C24)OCO5)COC3=O
Isomeric SMILES COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@@H](CC4=CC5=C(C=C24)OCO5)COC3=O
PubChem CID 345501
Molecular Weight 398.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
E2530343 Certificate of Analysis Nov 04, 2024 D651721
E2530345 Certificate of Analysis Nov 04, 2024 D651721
E2530347 Certificate of Analysis Nov 04, 2024 D651721
E2530354 Certificate of Analysis Nov 04, 2024 D651721
E2530367 Certificate of Analysis Nov 04, 2024 D651721
E2530342 Certificate of Analysis Nov 04, 2024 D651721
E2530346 Certificate of Analysis Nov 04, 2024 D651721

Chemical and Physical Properties

Solubility DMSO : 100 mg/mL (251.00 mM; Need ultrasonic)
Molecular Weight 398.400 g/mol
XLogP3 3.100
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 4
Exact Mass 398.137 Da
Monoisotopic Mass 398.137 Da
Topological Polar Surface Area 72.500 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 598.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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    Deoxypodophyllotoxin

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