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Degrasyn (WP1130) - ≥98%, high purity , CAS No.856243-80-6

COA

Grade & Purity:

≥98%

Cas Number: 856243-80-6
Molecular Weight: 384.27
PubChem CID: 11222830
PubChem SID: 504766179

In stock

Item Number

W126205

Grouped product items
SKU	Size	Availability	Price
W126205-5mg	5mg	3	$77.90
W126205-10mg	10mg	3	$136.90
W126205-25mg	25mg	2	$308.90
W126205-50mg	50mg	2	$508.90
W126205-100mg	100mg	2	$888.90

View related series

Apoptosis (4276) Autophagy (1917) Bcr-Abl (59) Cell Cycle/DNA Damage (2602) Deubiquitinase (86) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314) Unfolded Protein Response (214)

Basic Description

Synonyms	WP1130 \| WP-1130 \| Degrasyn (WP1130) \| SCHEMBL1317674 \| SCHEMBL882501 \| DTXSID50459281 \| s11144 \| WP1130(Degrasyn) \| Z2312381828 \| AMY20034 \| (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide \| EX-A2048 \| AC-28415 \| BDBM50437695 \| HY-13264
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	WP1130 induces rapid down-regulation of Bcr/Abl without affecting Bcr or c-Abl and regulates the stability of Jak2 and c-Myc without affecting other kinases (HER1, HER2, c-kit, Fak, Erk1, Erk2, Akt, Btk, Src, and Src-related kinases) or transcription fact
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). A selective deubiquitinase inhibitor and also suppresses Bcr/Abl.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Halopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Halopyridines
Intermediate Tree Nodes	Not available
Direct Parent	2-halopyridines
Alternative Parents	Benzene and substituted derivatives Aryl bromides Heteroaromatic compounds Secondary carboxylic acid amides Nitriles Azacyclic compounds Organobromides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-halopyridine - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Nitrile - Carbonitrile - Carboxylic acid derivative - Azacycle - Organic oxide - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Carbonyl group - Cyanide - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 2-halopyridines. These are organic compounds containing a pyridine ring substituted at the 2-position by a halogen atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

A-375 (9258 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

K562 (73714 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP5 Tchem Ubiquitin carboxyl-terminal hydrolase 5 (172 Activities)

Discover Target: USP5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)

Discover Target: USP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-266 (527 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP9X Tbio Probable ubiquitin carboxyl-terminal hydrolase FAF-X (500 Activities)

Discover Target: USP9X

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504766179
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766179
IUPAC Name	(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide
INCHI	InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
InChIKey	LIDOPKHSVQTSJY-VMEIHUARSA-N
Smiles	CCCC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
Isomeric SMILES	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
PubChem CID	11222830
Molecular Weight	384.27

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
I2205448	Certificate of Analysis	Jun 20, 2024	W126205
I2205449	Certificate of Analysis	Jun 20, 2024	W126205
I2205450	Certificate of Analysis	Jun 20, 2024	W126205
I2205451	Certificate of Analysis	Jun 20, 2024	W126205
I2205452	Certificate of Analysis	Jun 20, 2024	W126205

Chemical and Physical Properties

Solubility	Soluble in DMSO (77 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), ethanol (50 mg/ml at 25 °C), DMF (~20 mg/ml), and 1: 10 solution of DMF: PBS (pH 7.2) (~0.09 mg/ml).
Molecular Weight	384.300 g/mol
XLogP3	4.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	383.063 Da
Monoisotopic Mass	383.063 Da
Topological Polar Surface Area	65.800 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	490.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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Degrasyn (WP1130) - ≥98%, high purity , CAS No.856243-80-6

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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