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DC0-NH2 - 10mM in DMSO, high purity , CAS No.615538-51-7(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 615538-51-7(DMSO)
Molecular Weight: 550.01

In stock

Item Number

D656161

Grouped product items
SKU	Size	Availability	Price	Qty
D656161-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,186.90

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Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylat
Storage Temp	Argon charged,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component In Vitro DC0-NH2 (0-3 nM; 72 hours) is highly potent against Ramos, Namalwa, and HL60/s cells with IC 50 values in the 1 pM to 10 pM range, and has 100 pM range when tested on COLO 205 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Ramos, Namalwa, HL60/s, and COLO 205 Cancer Cells Concentration: 0-3 nM Incubation Time: 72 hours Result: Inhibited Namalwa and HL60/s cells with IC 50 s of 7 and 30 pM, respectively. IC50& Target:Duocarmycins

Names and Identifiers

Smiles	C1C(C2=C(N1C(=O)C3=CC4=C(N3)C=CC(=C4)NC(=O)C5=CC6=C(N5)C=CC(=C6)N)C=C(C7=CC=CC=C72)O)CCl
Molecular Weight	550.01

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