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DC-U4106 - 99%, high purity , CAS No.2410534-62-0

COA

Grade & Purity:

≥99%

Cas Number: 2410534-62-0
Molecular Weight: 525.56

In stock

Item Number

D648409

Grouped product items
SKU	Size	Availability	Price	Qty
D648409-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$780.90
D648409-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90

View related series

Apoptosis (4276) Cell Cycle/DNA Damage (2602) Deubiquitinase (86) Unfolded Protein Response (214)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	DC-U4106 is a USP8 targeting inhibitor with the K d value of 4.7 μM and the IC 50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα . DC-U4106 inhibits tumor growth with minimal toxicity and has the potential
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	DC-U4106 is a USP8 targeting inhibitor with the K d value of 4.7 μM and the IC 50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα . DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer In Vitro DC-U4106 (1.2-45.2 μM) inhibits USP8 and USP2 with the IC 50 values of 1.2 μM and 58.4 μM, respectively, and no activity in USP7. DC-U4106 (0-7 μM, 24 hours) reduces mRNA levels of ERα and PR. DC-U4106 (0-5 μM, 24 hours) can regulate the RTK pathway related proteins and the expression of ERα and PR proteins. DC-U4106 (0-5 μM, 12 hours) can induce apoptosis and inhibit cell proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: USP8-positive cell line MCF-7 Concentration: 0-5 μM Incubation Time: 24 hours Result: Reduced the expression of EGFR, ErbB2, and ErbB3 proteins with increasing concentrations and caused degradation of ERα and PR proteins. RT-PCRCell Line: USP8-positive cell line MCF-7 Concentration: 0-7 μM Incubation Time: 24 hours Result: Reduced mRNA levels of ERα and PR. Cell Proliferation AssayCell Line: USP8-positive cell line MCF-7 Concentration: 0-5 μM Incubation Time: Result: Inhibited cell growth in a dose-dependent manner. Apoptosis AnalysisCell Line: USP8-positive cell line MCF-7 Concentration: 0-5 μM Incubation Time: 12 hours Result: Resulted in increasing in the proportion of apoptotic cells with increasing concentrations. In Vivo DC-U4106 (intraperitoneal injection, 5 mg/kg or 20 mg/kg, every 2 days, 14 days) inhibits the proliferation of tumors and no significantly effects on body weight, organ morphology and structure in BALB/c nude mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c nude mice Dosage: 5 mg/kg , 20 mg/kg Administration: Intraperitoneal injection, Every 2 days, 14 days Result: Inhibited tumor growth significantly at a concentration of 20 mg/kg. Form:Solid IC50& Target:Kd: 4.7 μM (USP8), IC50: 1.2 μM (USP8)

Names and Identifiers

Smiles	O=C1C=C(C2=CC=C(N3CCN(C4=NC=CC=C4)CC3)C=C2)OC5=C1C(O)=CC(O)=C5OC6=C(C)NN=C6C
Molecular Weight	525.56

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