This is a demo store. No orders will be fulfilled.
Basic Information
ID: ALA1148529
Journal: J Med Chem
Title: Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.
Authors: Zhou L, Liu Y, Zhang W, Wei P, Huang C, Pei J, Yuan Y, Lai L.
Abstract: A series of isatin derivatives were synthesized and tested against SARS CoV 3C-like protease. Substitutions at the N-1 and C-5 positions were examined to elucidate the differences in substrate binding sites of the rhinovirus 3C protease and SARS CoV 3C-like protease. Compound 5f shows significant inhibition with an IC(50) of 0.37 microM. Further study showed that, unlike the irreversible covalent binding of isatin derivatives to human rhinovirus 3C protease, the compounds tested in this study are all noncovalent reversible inhibitors.
CiteXplore: 16759084
DOI: 10.1021/jm0602357
Patent ID: ┄
Associated Items:
Associated Bioactivities
Associated Assays
Associated Compounds
Associated Targets
Remind me later