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Basic Information
ID: ALA1134040
Journal: Bioorg Med Chem Lett
Title: Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.
Authors: Sandanayaka VP, Feigelson GB, Prashad AS, Yang Y, Petersen PJ.
Abstract: Several alkenyl derivatives were prepared using allyl penam sulfone as the key intermediate. Isomers of these derivatives having beta configuration at C-6 showed potent activity against CcrA enzyme. A new method was developed to prepare propargyl penam sulfone. The majority of the triazoles prepared by this route exhibited good activity against all three representative enzymes used for the inhibition assay.
CiteXplore: 11327608
DOI: 10.1016/s0960-894x(01)00148-2
Patent ID: ┄
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