DTXSID4044585 | EINECS 238-706-8 | Sodium 3-(((5-(4-nitrophenyl)furan-2-yl)methylene)amino)-2,5-dioxoimidazolidin-1-ide | HMS3675A14 | 2,4-Imidazolidinedione, 1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-, sodium salt | NCGC00255731-01 | SY078930 | D
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Ryanodine receptor antagonist. Calcium channel inhibitor. Reduces calcium flux across the sarcoplasmic reticulum. Displays selectivity for RYR1 and RYR3 over RYR2. Crosses the blood-brain barrier and active in vivo.
Shipped In
Normal
Action Type
ANTAGONIST
Mechanism of action
Ryanodine receptor 3 antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Dantrolene is a small molecule inhibitor of the Ryanodine receptor and a calcium channel protein inhibitor.Blockade of Ca2+ release from the sarcoendoplasmic reticulum, strongly related to excitation and contraction of muscles, generates a muscle relaxant effect correlated with Dantrolene. The neurotoxicity presented by pronounced glutamate activity is correlated to excessive rises in cytoplasmic Ca2+ levels, and Dantrolene is accordingly indicated as a neuroprotective agent against neurotrasmitter-induced excitotoxicity. Dantrolene, Sodium Salt is an inhibitor of RyR-1 and RyR-3. A calcium channel protein inhibitor.
This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
J2114456