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Daminozide - 10mM in DMSO, high purity , CAS No.1596-84-5, Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8

3 Citations COA COA
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Item Number
D421912
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D421912-1ml
1ml
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$69.90
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Selective histone demethylase KDM2/7 subfamily inhibitor

View related series
Compound libraries (12325) Histone Modification (1379)

Basic Description

Synonyms Daminozide | 1596-84-5 | Aminozide | Succinic acid 2,2-dimethylhydrazide | ALAR | DMASA | Kylar | N-(Dimethylamino)succinamic acid | Dimas | SADH | B-Nine | DYaK | Butanedioic acid, mono(2,2-dimethylhydrazide) | Alar 85 | Dimethylaminosuccinamic acid | 4-(2,2-dimethylhydrazinyl)-4-oxo
Specifications & Purity Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms

Description: IC50 Value: N/A Inhibition of shoot elongation in dwarf and tall peas by the 1,1-dimethylhydrazide of succinic acid (B-995) was correlated with the inhibition of the oxidation of tryptamine-2-C(14) to indoleacetaldehyde-2-C(1

Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8
Product Description

Product Introduction

Daminozide is a commonly used plant growth regulator, which acts by inhibiting 2-oxoglutarate-dependent dioxygenase activity in the gibberellin biosynthesis pathway.


Application

Daminozide may be used as a reference standard for the determination of daminozide in fruits and vegetables by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). It may also be used as a reference standard for the determination of daminozide in Ophiopogon japonicus plants and soil by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS). Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Fatty Acyls
Subclass Fatty acids and conjugates
Intermediate Tree Nodes Not available
Direct Parent Straight chain fatty acids
Alternative Parents Carboxylic acid hydrazides  Monocarboxylic acids and derivatives  Carboxylic acids  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic acyclic compounds
Substituents Straight chain fatty acid - Carboxylic acid hydrazide - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as straight chain fatty acids. These are fatty acids with a straight aliphatic chain.
External Descriptors Pesticides

Associated Targets(Human)

PHF8 Tchem Histone lysine demethylase PHF8 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KDM7A Tchem Lysine-specific demethylase 7A (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KDM2A Tchem Lysine-specific demethylase 2A (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGLN1 Tclin Egl nine homolog 1 (1702 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1AN Tbio Hypoxia-inducible factor 1-alpha inhibitor (79 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM2A Tchem Lysine-specific demethylase 2A (198 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM6B Tchem Lysine-specific demethylase 6B (280 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PHF8 Tchem Histone lysine demethylase PHF8 (151 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM6A Tchem Lysine-specific demethylase 6A (39 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BBOX1 Tchem Gamma-butyrobetaine dioxygenase (162 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM5C Tchem Lysine-specific demethylase 5C (224 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM7A Tchem Lysine-specific demethylase 7 (35 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM5A Tchem Lysine-specific demethylase 5A (893 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid
INCHI InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
InChIKey NOQGZXFMHARMLW-UHFFFAOYSA-N
Smiles CN(C)NC(=O)CCC(=O)O
Isomeric SMILES CN(C)NC(=O)CCC(=O)O
WGK Germany 2
RTECS WM9625000
Molecular Weight 160.17
Beilstein 1863230
Reaxy-Rn 1863230
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1863230&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Melt Point(°C) 154-155°C
Molecular Weight 160.170 g/mol
XLogP3 -3.100
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 4
Exact Mass 160.085 Da
Monoisotopic Mass 160.085 Da
Topological Polar Surface Area 69.600 Ų
Heavy Atom Count 11
Formal Charge 0
Complexity 156.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Pengshuai Zhang, Jixiu Deng, Xiaoyu Jiang, Liang Xu, Yu Huang, Han Sun, Mi Gao, Xianghan Wang, Yulong Gao, Kangning Fan, Lu Zhang, Shuoye Yang.  (2024)  Equilibrium solubility and thermodynamic study of daminozide in twelve neat solvents from (283.15 to 323.15) K.  JOURNAL OF CHEMICAL THERMODYNAMICS,  189  (107202). 
2. Linlu Shen, Hongyi Wang, Jing Kang, Jimin Shen, Pengwei Yan, Yingxu Gong, Jiaxu Zhang, Gang Fu, Shuyu Wang, Yizhen Cheng, Shengxin Zhao, Zhonglin Chen.  (2023)  Simultaneous elimination of N,N-dimethylhydrazine compounds and its oxidation by-product N-nitrosodimethylamine by UV-activated peroxymonosulfate process: Multiple-path mechanism validation and toxicity alteration.  CHEMICAL ENGINEERING JOURNAL,  474  (145837). 
3. Lan Sang, Shuyu Yang, Ying Zhu, Zhigang Zhu, Binrui Yang, Ziguang Li, Xin Mao, Siling Chen, Chengsi Li, Jun Du, Xiao Zheng, Hua He, Jianheng Zheng, Yin Huang.  (2024)  The combined use of B vitamins and probiotics promotes B vitamin absorption and increases Akkermansia abundance.  Food & Function,     

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