Skip to the beginning of the images gallery

Dactolisib Tosylate - 99%, high purity , CAS No.1028385-32-1

COA

Grade & Purity:

≥99%

Cas Number: 1028385-32-1
Molecular Weight: 641.74
PubChem CID: 49803145

In stock

Item Number

D647557

Grouped product items
SKU	Size	Availability	Price
D647557-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$37.90
D647557-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$72.90
D647557-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$108.90
D647557-200mg	200mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
D647557-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$360.90

View related series

Autophagy (1917) mTOR (145) PI3K (243) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	HEXAMETHYLDISILAZANE [MI] \| BEZ235 Tosylate \| BEZ-235 Tosylate \| SCHEMBL995465 \| 1028385-32-1 \| 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 4-methylbenzenesulfonate \| SB20063 \| DACTOLISI
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC 50 values of 4, 75, 7, 5 nM for PI3Kα , β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2 .
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC 50 values of 4, 75, 7, 5 nM for PI3Kα , β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2 . In Vitro Dactolisib (BEZ235) is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The IC 50 s for PI3Kα, β, γ, δ are 4, 75, 7, 5 nM, respectively. It is also found to be as active against the mutant PI3Kα E545K or PI3Kα H1047R with IC 50 s of 5.7 and 4.6 nM, respectively. In human tumor cell lines, it is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest. PTEN- cell lines PC3M and U87MG shows a dose-dependent reduction in cell proliferation when treated with increasing concentrations of Dactolisib (BEZ235), with an average GI 50 of 10 to 12 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Dactolisib (BEZ235) is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents. At a dose of 50 mg/kg, Dactolisib (BEZ235) appears rapidly in plasma with a C max of 1.68 μM at 0.5 h and a C 24h of 0.03 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:p110α 4 nM (IC 50 ) p110α-H1047R 4.6 nM (IC 50 ) p110α-E545K 5.7 nM (IC 50 ) p110γ 5 nM (IC 50 ) p110δ 7 nM (IC 50 ) p110β 75 nM (IC 50 ) mTOR 20.7 nM (IC 50 ) mTORC1 mTORC2 Autophagy

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Phenylquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Phenylquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylquinolines
Alternative Parents	Imidazoquinolines p-Methylbenzenesulfonates Phenylimidazoles Tosyl compounds Phenylpropanes 1-sulfo,2-unsubstituted aromatic compounds Imidazo-[4,5-c]pyridines Benzenesulfonyl compounds Pyridinones N-substituted imidazoles Sulfonyls Organosulfonic acids Heteroaromatic compounds Ureas Azacyclic compounds Nitriles Hydrocarbon derivatives Organic oxides Organooxygen compounds
Molecular Framework	Not available
Substituents	Phenylquinoline - Imidazoquinoline - P-methylbenzenesulfonate - 1-phenylimidazole - Benzenesulfonate - Tosyl compound - Arylsulfonic acid or derivatives - 1-sulfo,2-unsubstituted aromatic compound - Imidazopyridine - Imidazo-[4,5-c]pyridine - Phenylpropane - Benzenesulfonyl group - Pyridinone - Toluene - Pyridine - Benzenoid - N-substituted imidazole - Monocyclic benzene moiety - Azole - Imidazole - Heteroaromatic compound - Sulfonyl - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Urea - Nitrile - Carbonitrile - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Cyanide - Organic oxide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-methylbenzenesulfonic acid;2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
INCHI	InChI=1S/C30H23N5O.C7H8O3S/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36;1-6-2-4-7(5-3-6)11(8,9)10/h4-17H,1-3H3;2-5H,1H3,(H,8,9,10)
InChIKey	FWURTHAUPVXZHW-UHFFFAOYSA-N
Smiles	CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Isomeric SMILES	CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Alternate CAS	1028385-32-1
PubChem CID	49803145
NSC Number	753146
Molecular Weight	641.74

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 34 mg/mL (52.98 mM; Need ultrasonic and warming) H2O : <0.1 mg/mL (insoluble)
Molecular Weight	641.700 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	641.21 Da
Monoisotopic Mass	641.21 Da
Topological Polar Surface Area	136.000 Å²
Heavy Atom Count	47
Formal Charge	0
Complexity	1080.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration