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D-Phenylalanine - 2mM in Water, high purity , CAS No.673-06-3, Agonist of HCA 3 receptor

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Item Number
D425386
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D425386-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$182.90

Basic Description

Synonyms D-phenylalanine | 673-06-3 | H-D-Phe-OH | (2R)-2-amino-3-phenylpropanoic acid | Phenylalanine D-form | Sabiden | D-Phe | (R)-2-AMINO-3-PHENYLPROPANOIC ACID | Alanine, phenyl-, D- | NCI-C60195 | Phenylalanine,d- | D-alpha-Amino-beta-phenylpropionic acid | D-(+)-Phenylalanine | (R)-
Specifications & Purity Moligand™, 2mM in Water
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Agonist of HCA 3 receptor
Product Description

It is an essential amino acid with anti-depressant and analgesic activities. pharmaceutical intermediates, mainly used to treat, prevent osteoporosis, cardiovascular, diabetes, arterioscleros.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent Phenylalanine and derivatives
Alternative Parents Phenylpropanoic acids  D-alpha-amino acids  Amphetamines and derivatives  Aralkylamines  Amino acids  Monocarboxylic acids and derivatives  Carboxylic acids  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Phenylalanine or derivatives - 3-phenylpropanoic-acid - Alpha-amino acid - Amphetamine or derivatives - D-alpha-amino acid - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors Other amino acids

Associated Targets(Human)

HCAR3 Tchem Hydroxycarboxylic acid receptor 3 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA3 Tclin Carbonic anhydrase III (753 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA5B Tclin Carbonic anhydrase VB (957 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA5A Tclin Carbonic anhydrase VA (1168 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC16A10 SLC16A10 protein (28 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Ca7 Carbonic anhydrase VII (3 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ca13 Carbonic anhydrase XIII (322 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA4 Carbonic anhydrase IV (1713 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Carbonic anhydrase (69 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ca15 Carbonic anhydrase 15 (173 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAN2 Carbonic anhydrase 2 (140 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Carbonic anhydrase-like protein, putative (25 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2R)-2-amino-3-phenylpropanoic acid
INCHI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1
InChIKey COLNVLDHVKWLRT-MRVPVSSYSA-N
Smiles C1=CC=C(C=C1)CC(C(=O)O)N
Isomeric SMILES C1=CC=C(C=C1)C[C@H](C(=O)O)N
WGK Germany 3
RTECS AY7533000
Molecular Weight 165.19
Beilstein 2804068
Reaxy-Rn 1910407
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1910407&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Specific Rotation[α] 34 ° (C=2, H2O)
Melt Point(°C) 273-276°C
Molecular Weight 165.190 g/mol
XLogP3 -1.500
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 3
Exact Mass 165.079 Da
Monoisotopic Mass 165.079 Da
Topological Polar Surface Area 63.300 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 153.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang.  (2023)  Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning.  Advanced Science,  11  (9): (2307173). 
2. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai.  (2023)  Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.  Advanced Science,    (2308362). 
3. Jianrong Wang, Sha Han, Hongfang Zhao, Hongxia Li, Xiaohui Niu, Yi Wang, Kunjie Wang.  (2023)  Electrochemical enantioselective recognition by defined chiral linkers in polysaccharides modified with carbon quantum dots.  ELECTROANALYSIS,    (e202300301). 
4. Li Yuchen, Xu Guangfu, Chen Jiaquan, Yu Tao, Miao Pandeng, Du Yingxiang.  (2023)  One-step synthesis of chiral molecularly imprinted polymer TiO2 nanoparticles for enantioseparation of phenylalanine in coated capillary electrochromatography.  MICROCHIMICA ACTA,  190  (7): (1-11). 
5. Niu Xiaohui, Zhao Rui, Yan Simeng, Li Hongxia, Yang Jing, Cao Kunjie, Liu Xiaoyu, Wang Kunjie.  (2023)  Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors.  MICROCHIMICA ACTA,  190  (6): (1-12). 
6. Hou Huipeng, Tang Shanshan, Wang Wei, Liu Miao, Liang Axin, Xie Bingteng, Yi Yue, Luo Aiqin.  (2023)  Electrochemical Chiral Recognizing Tryptophan Enantiomers Based on Chiral Metal-Organic Framework D-MOF.  CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,  39  (6): (976-984). 
7. Qian Ye, Jin Li, Yinyin Huang, Hanbin Wu, Yilin Li, Bin Yan.  (2023)  Preparation of a cyclodextrin metal-organic framework (CD-MOF) membrane for chiral separation.  Journal of Environmental Chemical Engineering,  11  (109250). 
8. Jinglei Liu, Tianfei Chu, Mengmeng Cheng, Yan Su, Guizheng Zou, Shifeng Hou.  (2023)  Bovine serum albumin functional graphene oxide membrane for effective chiral separation.  JOURNAL OF MEMBRANE SCIENCE,  668  (121198). 
9. Yiyi Liu, Fangling Wu, Jiabin Wang, Ling Pu, Chuan-Fan Ding.  (2022)  Simultaneous chirality separation of amino acids and their derivative by natamycin based on mobility measurements.  ANALYTICA CHIMICA ACTA,  1227  (340298). 
10. Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng.  (2022)  Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production.  PROCESS BIOCHEMISTRY,  121  (681). 
11. Wancheng Qin, Peng Zhou, Xinyu Xu, Chuanwei Huang, Gopalan Srinivasan, Yajun Qi, Tianjin Zhang.  (2022)  High-Performance Piezoelectric Nanogenerator Based on Low-Entropy Structured Nanofibers for a Multi-Mode Energy Harvesting and Self-Powered Ultraviolet Photodetector.  ACS Applied Electronic Materials,  (6): (2970–2978). 
12. Yi Wu, Keren Lu, Fubin Pei, Yanghao Yan, Shasha Feng, Qingli Hao, Mingzhu Xia, Wu Lei.  (2022)  Construction of g-C3N4/Au/NH2-UiO-66 Z-scheme heterojunction for label-free photoelectrochemical recognition of D-penicillamine.  TALANTA,  248  (123617). 
13. Hongxia Li, Letong Wang, Simeng Yan, Jinliang Chen, Mengmeng Zhang, Rui Zhao, Xiaohui Niu, Kunjie Wang.  (2022)  Fusiform-like metal-organic framework for enantioselective discrimination of tryptophan enantiomers.  ELECTROCHIMICA ACTA,  419  (140409). 
14. Xiaohui Niu, Simeng Yan, Letong Wang, Jinliang Chen, Rui Zhao, Hongxia Li, Jian Liu, Kunjie Wang.  (2022)  Induction of chiral polymers from metal-organic framework for stereoselective recognition.  ANALYTICA CHIMICA ACTA,  1196  (339546). 
15. Xiaohui Niu, Simeng Yan, Jinliang Chen, Hongxia Li, Kunjie Wang.  (2022)  Enantioselective recognition of L/D-amino acids in the chiral nanochannels of a metal-organic framework.  ELECTROCHIMICA ACTA,  405  (139809). 
16. Xin-hui Zhou, Qing Liu, Hai-shui Wang.  (2022)  Chiral resolution of DL-glutamic acid by a chiral additive.  JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,  97  (5): (1240-1246). 
17. Xiaodan Wang, Fangping Yang, Huawei Yang, Xu Zhang, Haoyu Tang, Shifang Luan.  (2022)  Preparation of antibacterial polypeptides with different topologies and their antibacterial properties.  Biomaterials Science,  10  (3): (834-845). 
18. Liu Nijuan, Liu Jingjing, Niu Xiaohui, Wang Jia, Guo Ruibin, Mo Zunli.  (2021)  An electrochemical chiral sensor based on the synergy of chiral ionic liquid and 3D-NGMWCNT for tryptophan enantioselective recognition.  MICROCHIMICA ACTA,  188  (5): (1-13). 
19. Jia Wang, Zunli Mo, Nijuan Liu, Ruibin Guo, Chao Shuai, Fang Chen, Yongxin Du, Jingjing Liu, Guigui Liu, Qibing Dong, Qinqin Gao, Ying Chen, Wentong Liu.  (2021)  Construction of electrochemical chiral interface of C3N4/Ppy/ self-assembled polysaccharide.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,  886  (115118). 
20. Zou Jiao, Lan Xi-Wen, Zhao Guo-Qing, Huang Zhao-Ning, Liu Yi-Ping, Yu Jin-Gang.  (2020)  Immobilization of 6-O-α-maltosyl-β-cyclodextrin on the surface of black phosphorus nanosheets for selective chiral recognition of tyrosine enantiomers.  MICROCHIMICA ACTA,  187  (11): (1-11). 
21. Jiao Zou, Jin-Gang Yu.  (2020)  Nafion-stabilized black phosphorus nanosheets-maltosyl-β-cyclodextrin as a chiral sensor for tryptophan enantiomers.  Materials Science & Engineering C-Materials for Biological Applications,  112  (110910). 
22. Tingting Wang, Yuhuan Cheng, Yulian Zhang, Jinyin Zha, Jiannong Ye, Qingcui Chu, Guifang Cheng.  (2020)  β-cyclodextrin modified quantum dots as pseudo-stationary phase for direct enantioseparation based on capillary electrophoresis with laser-induced fluorescence detection.  TALANTA,  210  (120629). 
23. Jiao Zou, Jin-Gang Yu.  (2019)  Chiral recognition of tyrosine enantiomers on a novel bis-aminosaccharides composite modified glassy carbon electrode.  ANALYTICA CHIMICA ACTA,  1088  (35). 
24. Chunlei Ma, Wensheng Ren, Jianke Tang, Xiaoli Wang, Dongxin Ji, Rongqian Meng, Cuihong Zhang, Qi Wang.  (2019)  Copper nanocluster-based fluorescence enhanced determination of d-penicillamine.  LUMINESCENCE,  34  (7): (767-773). 
25. Yanhua Tu, Beixuan He, Songyan Gao, Dandan Guo, Xinlei Jia, Xin Dong, Meili Guo.  (2019)  CtACO1 Overexpression Resulted in the Alteration of the Flavonoids Profile of Safflower.  MOLECULES,  24  (6): (1128). 
26. Huang Lu, Li Yanxia, Lin Qi, Lou Benyong, Chen Yiting.  (2018)  Enantioselective permeations of amino acids through l-proline-modified gold nanochannel membrane: an experimental and theoretical study.  AMINO ACIDS,  50  (11): (1549-1556). 
27. Lili Guo, Baozhu Yang, Datong Wu, Yongxin Tao, Yong Kong.  (2018)  Chiral Sensing Platform Based on the Self-Assemblies of Diphenylalanine and Oxalic Acid.  ANALYTICAL CHEMISTRY,  90  (8): (5451–5458). 
28. Yanni Miao, Qi Liu, Wei Wang, Li Liu, Li Wang.  (2017)  Enantioseparation of amino acids by micellar capillary electrophoresis using binary chiral selectors and determination of D-glutamic acid and D-aspartic acid in rice wine.  JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,     
29. Xiaomei Lu, Jie Tang, Xinxin Dang, Xiaoli Jing, Kailin Xu, Hui Li, Bing Liang.  (2017)  Chiral recognition and determination of enantiomeric excess of chiral compounds by UV-visible-shortwave near infrared diffuse reflectance spectroscopy with chemometrics.  RSC Advances,  (22): (13552-13560). 
30. Yongxin Tao, Xiaogang Gu, Baozhu Yang, Linhong Deng, Liping Bao, Yong Kong, Fuqiang Chu, Yong Qin.  (2017)  Electrochemical Enantioselective Recognition in a Highly Ordered Self-Assembly Framework.  ANALYTICAL CHEMISTRY,  89  (3): (1900–1906). 
31. Datong Wu, Ying Zhou, Pengfei Cai, Shanshan Shen, Yuanjiang Pan.  (2015)  Specific cooperative effect for the enantiomeric separation of amino acids using aqueous two-phase systems with task-specific ionic liquids.  JOURNAL OF CHROMATOGRAPHY A,  1395  (65). 
32. Xiao-Yan Liu, Hong-Xun Fang, Li-Ping Yu.  (2013)  Molecularly imprinted photonic polymer based on β-cyclodextrin for amino acid sensing.  TALANTA,  116  (283). 
33. Chen Qi,Wenke Yang,Fuyan He,Jinshui Yao.  (2020-09-13)  The Thermal Properties and Degradability of Chiral Polyester-Imides Based on Several l/d-Amino Acids..  Polymers,  12  ((9)):  
34. Jin-Wen Liu, Tingting Chen, Meiqun Cai, Yingfeng Qin, Mei Li.  (2024)  A Dual-Mode Optical Sensing Strategy for Rapid Detection of D-Penicillamine in Pharmaceutical Formulations.  ANALYTICAL LETTERS,     
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37. Xiaohui Niu, Yongqi Liu, Rui Zhao, Mei Yuan, Hongfang Zhao, Hongxia Li, Kunjie Wang.  (2024)  Enhancing Electrochemical Signal for Efficient Chiral Recognition by Encapsulating C60 Fullerene into Chiral Lanthanum-Based MOFs.  ACS Applied Materials & Interfaces,  16  (14): (17361-17370). 
38. Wen-Bo Gao, Shu-Ting Xu, Yong-Jie Yan, Cheng Yang, Xiu-Ping Yan.  (2025)  Kinetic Method Coupled with Thermal-Assisted Paper Spray Ionization Mass Spectrometry for Direct Determination of Enantiomeric Excess of Multiple d/l-Amino Acids in Functional Foods.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,  36  (4): (906-913). 
39. Shen Yan, Fang Nan, Liu Xinru, Ling Yu, Su Yuming, Tan Tian, Chen Feng, Lin He, Zhao Boxuan, Wang Jin, Si Duanhui, Xie Shunji, Wang Ye, Zhou Da, Zhang Teng, Cao Rong, Wang Cheng.  (2025)  Observation of metal-organic interphase in Cu-based electrochemical CO2-to-ethanol conversion.  Nature Communications,  16  (1): (1-18). 
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