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D-α-Tocopherol Succinate - analytical standard, high purity , CAS No.4345-03-3

In stock
Item Number
T106366
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SKU Size
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Price Qty
T106366-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$82.90
View related series
Apoptosis (4276)

Basic Description

Synonyms vitamin e succinate | 4345-03-3 | alpha-Tocopheryl succinate | D-alpha-Tocopherol succinate | tocopherol succinate | alpha-tocopherol succinate | D-ALPHA-TOCOPHERYL SUCCINATE | Vitamin E hemisuccinate | Alpha-tocopherol succinate, d- | d-alpha-Tocopherol acid succinate | D- |
Specifications & Purity analytical standard
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade analytical standard
Product Description

D-α-Tocopheryl Succinate is a potent antioxidant tocopherol. At high concentrations it has been shown to trigger caspase-mediated apoptosis of certain cells and, at low concentrations, inhibit proliferation. Mechanistic studies suggest that this compound down-regulates the fibroblast growth factor receptor-1 (FGFR1). Other experiments report that D-α-Tocopheryl Succinate also targets ASK 1, GADD 45β, and MEK-4, three key components of stress-activated mitogen-activated protein kinase pathway.
A potent antioxidant tocopherol

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Prenol lipids
Subclass Quinone and hydroquinone lipids
Intermediate Tree Nodes Not available
Direct Parent Vitamin E compounds
Alternative Parents Diterpenoids  1-benzopyrans  Fatty acid esters  Alkyl aryl ethers  Dicarboxylic acids and derivatives  Benzenoids  Carboxylic acid esters  Oxacyclic compounds  Carboxylic acids  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Diterpenoid - Chromane - Benzopyran - 1-benzopyran - Alkyl aryl ether - Fatty acid ester - Fatty acyl - Dicarboxylic acid or derivatives - Benzenoid - Carboxylic acid ester - Carboxylic acid derivative - Oxacycle - Carboxylic acid - Organoheterocyclic compound - Ether - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as vitamin e compounds. These are a group of fat-soluble compounds containing or derived either from a tocopherol or a tocotrienol skeleton.
External Descriptors Not available

Associated Targets(Human)

GSTO1 Tchem Glutathione transferase omega 1 (164 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-BR-3 (5175 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver (3974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
4T1 (1737 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-oxo-4-[[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid
INCHI InChI=1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1
InChIKey IELOKBJPULMYRW-NJQVLOCASA-N
Smiles CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)O)C
Isomeric SMILES CC1=C(C(=C(C2=C1O[C@](CC2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)OC(=O)CCC(=O)O)C
WGK Germany 1
RTECS EJ9984000
Molecular Weight 530.78
Beilstein 4038233
Reaxy-Rn 1412198
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1412198&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

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Lot Number Certificate Type Date Item
L2110163 Certificate of Analysis Jun 10, 2025 T106366

Chemical and Physical Properties

Solubility Soluble in DMSO, chloroform (50 mg/ml), and ethanol. Insoluble in water.
Specific Rotation[α] 4° (C=8,EtOH)
Melt Point(°C) 75 °C
Molecular Weight 530.800 g/mol
XLogP3 10.200
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 17
Exact Mass 530.397 Da
Monoisotopic Mass 530.397 Da
Topological Polar Surface Area 72.800 Ų
Heavy Atom Count 38
Formal Charge 0
Complexity 720.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Zhuoran Li, Huikang Yang, Fan Xu, Xuwen Zeng, Haowei Huang, Xinqing Jiang.  (2023)  Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment.  Materials Research Express,  10  (11): (115404). 
2. Jun Li, Fangbo Yuan, Jiayou Teng, Fang Li, Penghui Zhou, Yanlan Bi.  (2023)  Effects of tea polyphenols and tertiary butylhydroquinone on quality of palm oils and losses of endogenous vitamin E during batch frying and oxidative stability of fried instant noodles.  Food Chemistry-X,  20  (101049). 
3. Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan.  (2023)  Enzyme and Reduction Dual-Responsive Peptide Micelles as Nanocarriers for Smart Drug Delivery.  ACS Applied Nano Materials,  (18): (16179–16188). 
4. Qianli Sheng, Min Yuan, Dan Wang, Yuanqi Kou, Lei Liu, Yan Chen, Shiyong Song.  (2023)  Injectable Hydrogels of Amphiphilic Vitamin E Derivatives for Locoregional Chemotherapy.  LANGMUIR,  39  (33): (11839–11850). 
5. Lihua Luo, Zhenyu Luo, Junlei Zhang, Xu Liu, Jiaxin Huang, Sijie Wang, Hang Yin, Xuemeng Guo, Yilong Hu, Yichao Lu, Xinyu Shan, Huihui Liu, Yingying Shi, Yongzhong Du, Fuchun Yang, Jian You.  (2023)  Preventing acute lung injury from progressing to pulmonary fibrosis by maintaining ERS homeostasis through a multistage targeting nanomicelle.  Nano Today,  48  (101719). 
6. Dong Wan, Yujun Liu, Xinhao Guo, Jianxin Zhang, Jie Pan.  (2022)  Intelligent Drug Delivery by Peptide-Based Dual-Function Micelles.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (17): (9698). 
7. Sunfan Li, Fangzhou Li, Dong Wan, Zuqin Chen, Jie Pan, Xing-Jie Liang.  (2023)  A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery.  Bioactive Materials,  25  (783). 
8. Guanting Li, Bingjun Sun, Shunzhe Zheng, Lu Xu, Wenhui Tao, Dongyang Zhao, Jiang Yu, Shuwen Fu, Xuanbo Zhang, Haotian Zhang, Yinglei Zhai, Cong Luo, Huaiwei Ding, Zhonggui He, Jin Sun.  (2021)  Zwitterion-Driven Shape Program of Prodrug Nanoassemblies with High Stability, High Tumor Accumulation, and High Antitumor Activity.  Advanced Healthcare Materials,  10  (23): (2101407). 
9. Miaomiao Long, Jiamin Xu, Wenjie Fang, Jing Mao, Jie Zhang, Shenhuan Liu, Lipeng Qiu.  (2021)  Enhanced delivery of artesunate by stimuli-responsive polymeric micelles for lung tumor therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  66  (102812). 
10. Dong Wan, Sunfan Li, Jianxin Zhang, Guilei Ma, Jie Pan.  (2021)  Intelligent self-assembly prodrug micelles loading doxorubicin in response to tumor microenvironment for targeted tumors therapy.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,  39  (219). 
11. Dan Ye, Liyan Shen, Ying Sun, Di Zhang, Xiao Tan, Panpan Jing, Min Zhang, Qingping Tian.  (2021)  Formulation and evaluation of a α-linolenic acid and vitamin E succinate microemulsion with low surfactant content and free of co-surfactant for use as a nutritional supplement.  FOOD CHEMISTRY,  364  (130433). 
12. Yunfeng Wan, Wenjie Yu, Jiami Li, Na Peng, Xiao Ding, Yanlong Wang, Tao Zou, Yang Cheng, Yi Liu.  (2021)  Multi-functional carboxymethyl chitin-based nanoparticles for modulation of tumor-associated macrophage polarity.  CARBOHYDRATE POLYMERS,  267  (118245). 
13. Ning Wang, Chenyu Liu, Weihe Yao, Hengjun Zhou, Simiao Yu, Hailiang Chen, Weihong Qiao.  (2021)  A traceable, GSH/pH dual-responsive nanoparticles with spatiotemporally controlled multiple drugs release ability to enhance antitumor efficacy.  COLLOIDS AND SURFACES B-BIOINTERFACES,  205  (111866). 
14. Hui Peng, Jia-Hui Wang, Feng Guo, Fang-Fang Zhu, Zu-Jun Wen, Hai-Jun Zhong, De-Sheng Liang.  (2021)  Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,  197  (111442). 
15. Zipeng Huang, Xinru Chen, Ying Li, Junqiu Zhai, Yan Ma.  (2021)  Excogitation and Assessment of Curcumin-Vitamin E Self-assembly PEGylated Nanoparticles by the Route of Oral Administration.  JOURNAL OF PHARMACEUTICAL SCIENCES,  110  (146). 
16. Li Yang, Lin Jinyan, Wang Peiyuan, Luo Qiang, Zhu Fukai, Zhang Yun, Hou Zhenqing, Liu Xiaolong, Liu Jingfeng.  (2020)  Tumor Microenvironment Cascade-Responsive Nanodrug with Self-Targeting Activation and ROS Regeneration for Synergistic Oxidation-Chemotherapy.  Nano-Micro Letters,  12  (1): (1-18). 
17. Di Zhang, Dan Ye, Panpan Jing, Xiao Tan, Lixia Qiu, Tingting Li, Liyan Shen, Ying Sun, Hongbao Hou, Yunshu Zhang, Qingping Tian.  (2020)  Design, optimization and evaluation of co-surfactant free microemulsion-based hydrogel with low surfactant for enhanced transdermal delivery of lidocaine.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  586  (119415). 
18. Xiao Ding, Wenjie Yu, Yunfeng Wan, Mingyue Yang, Chenghuan Hua, Na Peng, Yi Liu.  (2020)  A pH/ROS-responsive, tumor-targeted drug delivery system based on carboxymethyl chitin gated hollow mesoporous silica nanoparticles for anti-tumor chemotherapy.  CARBOHYDRATE POLYMERS,  245  (116493). 
19. Jia Li, Jihong Wang, Xuetong Zhang, Xin Xia, Chenchen Zhang.  (2019)  Biodegradable reduction-responsive polymeric micelles for enhanced delivery of melphalan to retinoblastoma cells.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  141  (997). 
20. Shujuan Xiong, Zhe Wang, Juan Liu, Xiangping Deng, Runde Xiong, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Yanming Chen, Guotao Tang.  (2019)  A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,  173  (346). 
21. Pan Jie, Lei Shuaiquan, Chang Lu, Wan Dong.  (2019)  Smart pH-responsive nanoparticles in a model tumor microenvironment for enhanced cellular uptake.  JOURNAL OF MATERIALS SCIENCE,  54  (2): (1692-1702). 
22. Shu Han, Ruiyang Sun, Hong Su, Jing Lv, Huan Xu, Di Zhang, Yuanshan Fu.  (2019)  Delivery of docetaxel using pH-sensitive liposomes based on D-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate: Comparison with PEGylated liposomes.  Asian Journal of Pharmaceutical Sciences,  14  (391). 
23. Songbai Liu, Zhan Wang, Min Ban, Peng Song, Xufeng Song, Bushra Khan.  (2018)  Chelation–assisted in situ self-assembly route to prepare the loose PAN–based nanocomposite membrane for dye desalination.  JOURNAL OF MEMBRANE SCIENCE,  566  (168). 
24. De-Sheng Liang, Jian Liu, Tao-Xing Peng, Hui Peng, Feng Guo, Hai-Jun Zhong.  (2018)  Vitamin E-based redox-sensitive salinomycin prodrug-nanosystem with paclitaxel loaded for cancer targeted and combined chemotherapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,  172  (506). 
25. Chunqi Zhu, Hanbo Zhang, Wei Li, Lihua Luo, Xiaomeng Guo, Zuhua Wang, Fenfen Kong, Qingpo Li, Jie Yang, Yongzhong Du, Jian You.  (2018)  Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle.  BIOMATERIALS,  161  (144). 
26. Jing-Jing Hu, Qi Lei, Meng-Yun Peng, Di-Wei Zheng, Yi-Xuan Chen, Xian-Zheng Zhang.  (2017)  A positive feedback strategy for enhanced chemotherapy based on ROS-triggered self-accelerating drug release nanosystem.  BIOMATERIALS,  128  (136). 
27. Yu Liu, Jia Yang, Xin Wang, Ju Liu, Zhaobo Wang, Hongsheng Liu, Lijiang Chen.  (2016)  In vitro and in vivo evaluation of redox-responsive sorafenib carrier nanomicelles synthesized from poly (acryic acid) -cystamine hydrochloride-D-α-tocopherol succinate.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,  27  (17): (1729-1747). 
28. Yanfen Fang, Fang Du, Yanyun Xu, Haijing Meng, Jin Huang, Xiongwen Zhang, Wei Lu, Shiyuan Liu, Jiahui Yu.  (2015)  Enhanced cellular uptake and intracellular drug controlled release of VESylated gemcitabine prodrug nanocapsules.  COLLOIDS AND SURFACES B-BIOINTERFACES,  128  (357). 
29. Yanyun Xu,Haijing Meng,Fang Du,Wei Lu,Shiyuan Liu,Jin Huang,Jiahui Yu.  (2015-09-28)  Preparation of intravenous injection nanoformulation of VESylated gemcitabine by co-assembly with TPGS and its anti-tumor activity in pancreatic tumor-bearing mice..  International journal of pharmaceutics,  495  ((2)): (792-797). 
30. Yue Zhongqun, Zhu Yue, Chen Teng, Feng Tingting, Zhou Ying, Zhang Jiaojiao, Zhang Ning, Yang Jing, Luo Gang, Wang Zuhua.  (2024)  Bletilla striata polysaccharide-coated andrographolide nanomicelles for targeted drug delivery to enhance anti-colon cancer efficacy.  Frontiers in Immunology,  15   
31. Wenlin Li, Sen Lin, Dongming Lan, Yonghua Wang.  (2024)  Efficient enzymatic synthesis of vitamin E succinate using an organic solvent-stable immobilized lipase.  JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY,     
32. Qianqian Gao, Tingting Liu, Li Sun, Yongliang Yao, Fang Li, Lingxiang Mao.  (2024)  Triggered ferroptotic albumin-tocopherol nanocarriers for treating drug-resistant breast cancer.  Frontiers in Oncology,  14  (1464909). 

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