This is a demo store. No orders will be fulfilled.

Cycloheximide (NSC-185) - 10mM in DMSO, high purity , CAS No.66-81-9(DMSO), 80S Ribosome inhibitor

In stock
Item Number
C408230
Grouped product items
SKU Size
Availability
Price Qty
C408230-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$237.90

Fungal Inhibitors

View related series
Compound libraries (12325)

Basic Description

Synonyms Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80 | 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Specifications & Purity Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximid
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action 80S Ribosome inhibitor
Product Description

Information

Cycloheximide (NSC-185) Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo,
In vitro


In vivo


Cell Data

cell lines:HT29, Colo205, PC-3, MDA-MB-231 and K562 cells

Concentrations:

Incubation Time:

Powder Purity:≥97%

Product Properties

ALogP 0.933
hba_count 3
HBD Count 2
Rotatable Bond 3

Associated Targets(Human)

EIF4A1 Tchem Eukaryotic initiation factor 4A-I (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Smiles CC1CC(C)C(=O)C(C1)C(O)CC2CC(=O)NC(=O)C2
Molecular Weight 281.35
Reaxy-Rn 9515475
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9515475&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 53 mg/mL (79.62 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility 56
DMSO(mM) Max Solubility 199.04
Water(mg / mL) Max Solubility 15
Water(mM) Max Solubility 53.31

Citations of This Product

1. Zhang Chen-chun, Li Yuan, Jiang Chang-you, Le Qiu-min, Liu Xing, Ma Lan, Wang Fei-fei.  (2024)  O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1.  ACTA PHARMACOLOGICA SINICA,    (1-14). 

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.