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| SKU | Size | Availability |
Price | Qty |
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C408230-1ml
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1ml |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$237.90
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Fungal Inhibitors
| Synonyms | Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80 | 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximid |
| Storage Temp | Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | 80S Ribosome inhibitor |
| Product Description |
Information Cycloheximide (NSC-185) Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, In vivo
cell lines:HT29, Colo205, PC-3, MDA-MB-231 and K562 cells Concentrations: Incubation Time: Powder Purity:≥97% |
| ALogP | 0.933 |
|---|---|
| hba_count | 3 |
| HBD Count | 2 |
| Rotatable Bond | 3 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Smiles | CC1CC(C)C(=O)C(C1)C(O)CC2CC(=O)NC(=O)C2 |
|---|---|
| Molecular Weight | 281.35 |
| Reaxy-Rn | 9515475 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9515475&ln= |
| Solubility | Solubility (25°C) In vitro DMSO: 53 mg/mL (79.62 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 56 |
| DMSO(mM) Max Solubility | 199.04 |
| Water(mg / mL) Max Solubility | 15 |
| Water(mM) Max Solubility | 53.31 |
| 1. Zhang Chen-chun, Li Yuan, Jiang Chang-you, Le Qiu-min, Liu Xing, Ma Lan, Wang Fei-fei. (2024) O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1. ACTA PHARMACOLOGICA SINICA, (1-14). |