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Small Molecules & Compound Libraries
Signaling Pathways
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Toll-like Receptor (TLR)
CU CPT 9a - ≥98%(HPLC), high purity , CAS No.2165340-32-7

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CU CPT 9a - ≥98%(HPLC), high purity , CAS No.2165340-32-7

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 2165340-32-7
Molecular Weight: 265.31
PubChem CID: 135567383
PubChem SID: 504773401

In stock

Item Number

C288811

Grouped product items
SKU	Size	Availability	Price
C288811-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$98.90
C288811-10mg	10mg	2	$157.90
C288811-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$355.90
C288811-50mg	50mg	2	$543.90
C288811-100mg	100mg	2	$840.90

Highly potent TLR8 inhibitor

View related series

Immunology/Inflammation (1929) Toll-like Receptor (TLR) (148)

Basic Description

Synonyms	4-(7-methoxyquinolin-4-yl)-2-methylphenol \| 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol \| BS-16510 \| s9730 \| 2165340-32-7 \| EX-A3051 \| CU CPT 9a \| HY-112667 \| AC-36561 \| 4-(7-Methoxy-4-quinolinyl)-2-methylphenol \| 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent TLR8 inhibitor (IC50= 0.5 nM and Kd= 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. CU-CPT9a is a potent and selective
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Phenylquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Phenylquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylquinolines
Alternative Parents	Phenylpyridines Ortho cresols Anisoles Toluenes Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenylquinoline - 4-phenylpyridine - O-cresol - Anisole - 1-hydroxy-2-unsubstituted benzenoid - Toluene - Phenol - Alkyl aryl ether - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TLR8 Tchem Toll-like receptor 8 (1 Activities)

Discover Target: TLR8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504773401
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773401
IUPAC Name	4-(7-methoxyquinolin-4-yl)-2-methylphenol
INCHI	InChI=1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3
InChIKey	HNYBTVKYLVLWCB-UHFFFAOYSA-N
Smiles	CC1=C(C=CC(=C1)C2=C3C=CC(=CC3=NC=C2)OC)O
Isomeric SMILES	CC1=C(C=CC(=C1)C2=C3C=CC(=CC3=NC=C2)OC)O
Molecular Weight	265.31
Reaxy-Rn	32065721
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32065721&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
J2114233	Certificate of Analysis	Jul 17, 2024	C288811
J2114234	Certificate of Analysis	Jul 17, 2024	C288811
J2114235	Certificate of Analysis	Jul 17, 2024	C288811
J2114236	Certificate of Analysis	Jul 17, 2024	C288811
J2114259	Certificate of Analysis	Jul 17, 2024	C288811

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 26.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.31, Max Conc. mM: 20
Molecular Weight	265.310 g/mol
XLogP3	3.800
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	265.11 Da
Monoisotopic Mass	265.11 Da
Topological Polar Surface Area	42.400 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	322.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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