Skip to the beginning of the images gallery

Crolibulin - 98%, high purity , Tubulin inhibitor, CAS No.1000852-17-4, Tubulin inhibitor

Grade & Purity:

≥98%

Cas Number: 1000852-17-4
Molecular Weight: 417.26
PubChem CID: 23649181

In stock

Item Number

C647301

Grouped product items
SKU	Size	Availability	Price
C647301-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$200.90
C647301-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$360.90
C647301-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
C647301-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90

View related series

Apoptosis (4276) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Cytoskeleton (498) Microtubule/Tubulin (199)

Synonyms	(R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile \| EPC2407 \| EPC-2407 \| Q252344 \| D09882 \| 1000852-17-4 \| AT-20GF \| JXONINOYTKKXQQ-CQSZACIVSA-N \| BG0 \| CROLIBULIN [WHO-DD] \| UNII-9ENT43KY91 \| Q27272449 \| CROLIBULIN [INN] \| EX-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Tubulin inhibitor
Product Description	Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity In Vitro Crolibulin shows significant cytotoxic activity against HT-29 cells, with an IC 50 of 0.52 μM. Crolibulin is active against various experimental tumors and exhibit potent inhibition of mitosis at the G2/M stage. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Tubulin polymerization

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Neoflavonoids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Neoflavonoids
Alternative Parents	Dimethoxybenzenes 1-benzopyrans Phenoxy compounds Anisoles Bromobenzenes Alkyl aryl ethers Aryl bromides Ketene acetals Oxacyclic compounds Nitriles Primary amines Organobromides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Neoflavonoid skeleton - Benzopyran - 1-benzopyran - O-dimethoxybenzene - Dimethoxybenzene - Anisole - Phenoxy compound - Phenol ether - Methoxybenzene - Alkyl aryl ether - Bromobenzene - Halobenzene - Benzenoid - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Ketene acetal or derivatives - Organoheterocyclic compound - Oxacycle - Nitrile - Carbonitrile - Ether - Primary amine - Organic nitrogen compound - Cyanide - Amine - Organic oxygen compound - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as neoflavonoids. These are compounds with a structure based on the 4-phenylchromene backbone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	(4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
INCHI	InChI=1S/C18H17BrN4O3/c1-24-13-6-8(5-11(19)17(13)25-2)14-9-3-4-12(21)15(22)16(9)26-18(23)10(14)7-20/h3-6,14H,21-23H2,1-2H3/t14-/m1/s1
InChIKey	JXONINOYTKKXQQ-CQSZACIVSA-N
Smiles	COC1=C(C(=CC(=C1)C2C3=C(C(=C(C=C3)N)N)OC(=C2C#N)N)Br)OC
Isomeric SMILES	COC1=C(C(=CC(=C1)[C@@H]2C3=C(C(=C(C=C3)N)N)OC(=C2C#N)N)Br)OC
PubChem CID	23649181
Molecular Weight	417.26

Solubility	DMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming)
Molecular Weight	417.300 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	416.048 Da
Monoisotopic Mass	416.048 Da
Topological Polar Surface Area	130.000 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	606.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Crolibulin - 98%, high purity , Tubulin inhibitor, CAS No.1000852-17-4, Tubulin inhibitor

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews