MCC950 sodium | 256373-96-3 | CRID3 sodium salt | CP-456773 sodium | MCC950 sodium salt | MCC950 (sodium) | CP-456773 sodium salt | MCC-950 sodium salt | CP-456,773 sodium salt | CHEMBL4750616 | 256373-96-3 (sodium) | 66BL55B687 | Sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)ca
Specifications & Purity
10mM in Water
Biochemical and Physiological Mechanisms
Potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50values are 7.2, 10.3 and 12-18 nM
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
application：
CP-456773 sodium salt has been used :
In in vivo experiments to study the neuroprotective action of ketogenic diet.
To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.
This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
