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CPTH2 - 10mM in DMSO, high purity , CAS No.357649-93-5
Basic Description
Synonyms
CPTH2 | 357649-93-5 | 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole | Histone Acetyltransferase Inhibitor IV, CPTH2 | CHEMBL246811 | CHEBI:77993 | 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole | cyclopentylidene-[4-(4-chlorophenyl)thiazol-2
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network where HATs act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of e
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Azoles
Subclass
Thiazoles
Intermediate Tree Nodes
Not available
Direct Parent
2,4-disubstituted thiazoles
Alternative Parents
Chlorobenzenes Aryl chlorides Heteroaromatic compounds Hydrazones Azacyclic compounds Organopnictogen compounds Organochlorides Hydrocarbon derivatives
Molecular Framework
Aromatic heteromonocyclic compounds
Substituents
2,4-disubstituted 1,3-thiazole - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Azacycle - Hydrazone - Organochloride - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organohalogen compound - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
External Descriptors
1,3-thiazole - monochlorobenzenes - ring assembly - hydrazone
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
4-(4-chlorophenyl)-N-(cyclopentylideneamino)-1,3-thiazol-2-amine
INCHI
InChI=1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)
InChIKey
YYTHPXHGWSAKIZ-UHFFFAOYSA-N
Smiles
C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C1
Isomeric SMILES
C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C1
Molecular Weight
291.8
Reaxy-Rn
18559523
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18559523&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
291.800 g/mol
XLogP3
4.200
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Exact Mass
291.06 Da
Monoisotopic Mass
291.06 Da
Topological Polar Surface Area
65.500 Ų
Heavy Atom Count
19
Formal Charge
0
Complexity
321.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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