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Corylifol A - 99%, high purity , CAS No.775351-88-7

COA

Grade & Purity:

≥99%

Cas Number: 775351-88-7
Molecular Weight: 390.47
PubChem CID: 25056407

In stock

Item Number

C648628

Grouped product items
SKU	Size	Availability	Price
C648628-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$78.90
C648628-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$165.90
C648628-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$275.90

Flavonoids Isoflavones Phenols Polyphenols

View related series

Flavonoids Isoflavones Phenols Polyphenols (13) Glucose Metabolism (1943) JAK/STAT Signaling (507) STAT (139) Stem Cell/Wnt (1019)

Basic Description

Synonyms	AKOS032948982 \| MS-26509 \| 3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one \| Corylinin \| 3'-Geranyl-4',7-dihydroxyisoflavone \| BCP18858 \| AC-34049 \| HY-N0897 \| DTXSID401345950 \| SCHEMBL23028385 \| Corylifol A
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC 50 of 0.81 μM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC 50 of 0.81 μM. In Vitro Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC 50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC 50 s ranging between 4.2 and 38.4 μM. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low K i values ranging from 0.62 μM to 3.89 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:STAT3 0.81 μM (IC 50 )

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Isoflavonoids
    - Subclass Isoflav-2-enes

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Isoflavonoids
Subclass	Isoflav-2-enes
Intermediate Tree Nodes	Not available
Direct Parent	Isoflavones
Alternative Parents	Hydroxyisoflavonoids Chromones Bicyclic monoterpenoids Aromatic monoterpenoids Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Heteroaromatic compounds Oxacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Hydroxyisoflavonoid - Isoflavone - Chromone - Aromatic monoterpenoid - Benzopyran - Bicyclic monoterpenoid - Monoterpenoid - 1-benzopyran - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Heteroaromatic compound - Organoheterocyclic compound - Oxacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as isoflavones. These are polycyclic compounds containing a 2-isoflavene skeleton which bears a ketone group at the C4 carbon atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one
INCHI	InChI=1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+
InChIKey	ZBHUUXLHDOUMKM-REZTVBANSA-N
Smiles	CC(=CCCC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C)C
Isomeric SMILES	CC(=CCC/C(=C/CC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)/C)C
Alternate CAS	775351-88-7
PubChem CID	25056407
MeSH Entry Terms	corylifol A
Molecular Weight	390.47

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 250 mg/mL (640.25 mM; Need ultrasonic)
Molecular Weight	390.500 g/mol
XLogP3	6.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	390.183 Da
Monoisotopic Mass	390.183 Da
Topological Polar Surface Area	66.800 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	670.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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