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Cortistatin 14, CAS No.193829-96-8
Endogenous neuropeptide; binds sst1- sst5, ghrelin receptor and MRGPRX2
Basic Description
Product Name
Cortistatin 14, CAS No.193829-96-8
Synonyms
Cortistatin 14 | PUBCHEM_16133803 | Cortistatin-14, >=97% (HPLC) | CST-14 | cortistatin | AKOS024457590 | DTXSID00583202 | HY-P1212 | Cortistatin 14, human, rat | CAS_186901-48-4 | Cortistatin-14 (trifluoroacetate salt) | Corticostatin-14 | BDBM85324 | co
Biochemical and Physiological Mechanisms
Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1- sst5) and prevents somatostatin-14 binding (IC50values are 5
Sequence
PCKNFFWKTFSSCK(Modifications: Disulfide bridge between 2 - 13)
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organic Polymers
Class
Polypeptides
Subclass
Not available
Intermediate Tree Nodes
Not available
Direct Parent
Polypeptides
Alternative Parents
Cyclic peptides Macrolactams N-acyl-L-alpha-amino acids Proline and derivatives Alpha amino acid amides 3-alkylindoles Medium-chain fatty acids Pyrrolidinecarboxamides Heterocyclic fatty acids Amino fatty acids Hydroxy fatty acids Substituted pyrroles Benzene and substituted derivatives Heteroaromatic compounds Primary carboxylic acid amides Organic disulfides Amino acids Lactams Secondary alcohols Secondary carboxylic acid amides Monocarboxylic acids and derivatives Azacyclic compounds Carboxylic acids Dialkylamines Organic oxides Hydrocarbon derivatives Carbonyl compounds Primary alcohols Monoalkylamines
Molecular Framework
Aromatic heteropolycyclic compounds
Substituents
Polypeptide - Cyclic alpha peptide - Macrolactam - Proline or derivatives - N-acyl-alpha-amino acid - N-acyl-l-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Medium-chain fatty acid - Hydroxy fatty acid - Heterocyclic fatty acid - Amino fatty acid - Monocyclic benzene moiety - Fatty acyl - Fatty acid - Benzenoid - Substituted pyrrole - Pyrrole - Heteroaromatic compound - Pyrrolidine - Primary carboxylic acid amide - Carboxamide group - Amino acid - Lactam - Amino acid or derivatives - Organic disulfide - Secondary alcohol - Secondary carboxylic acid amide - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Secondary amine - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Organic oxide - Amine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Alcohol - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Aromatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Storage and Shipping
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
CAS
193829-96-8
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Citations of This Product
1.
Yuanyuan Ding, Tianyou Ma, Yonghui Zhang, Chenrui Zhao, Chao Wang, Zhao Wang.
(2023)
Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLCγ1 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY,
117
(110003).
2.
Yilei Guo, Dandan Sun, Yajing Zhang, Xiaoxiao Yu, Yulai Fang, Changjun Lv, Qin Zhang, Yanrong Zhu, Simiao Qiao, Yufeng Xia, Zhifeng Wei, Yue Dai.
(2022)
The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1. INTERNATIONAL IMMUNOPHARMACOLOGY,
108
(108843).
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2 Citations