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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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C119329-100mg
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100mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$23.90
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C119329-500mg
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500mg |
1
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$90.90
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Potent endogenous glucocorticoid and mineralocorticoid receptor agonist
| Synonyms | (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | A | HMS3713G06 | (11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione | Corticosterone, 1mg/ml in Methanol | N |
|---|---|
| Specifications & Purity | Moligand™, analytical standard |
| Biochemical and Physiological Mechanisms | Corticosterone is a hormone synthesized in response to stress. It binds and activates MCRs(mineralocorticoid receptors) and GRs (glucocorticoid receptors), which results in altered expression. This eventually affects ionic conductances through the membran |
| Shipped In | Normal |
| Grade | analytical standard, Moligand™ |
| Action Type | AGONIST |
| Mechanism of action | Agonist of Glucocorticoid receptor;Agonist of Mineralocorticoid receptor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Corticosteroid is an activator of MCR. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Steroids and steroid derivatives |
| Subclass | Hydroxysteroids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 21-hydroxysteroids |
| Alternative Parents | Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-oxo delta-4-steroids 11-beta-hydroxysteroids Delta-4-steroids Cyclohexenones Alpha-hydroxy ketones Secondary alcohols Cyclic alcohols and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic homopolycyclic compounds |
| Substituents | Progestogin-skeleton - 21-hydroxysteroid - Pregnane-skeleton - 20-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - 11-hydroxysteroid - 11-beta-hydroxysteroid - Oxosteroid - Delta-4-steroid - Cyclohexenone - Alpha-hydroxy ketone - Cyclic alcohol - Ketone - Secondary alcohol - Cyclic ketone - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Alcohol - Organooxygen compound - Primary alcohol - Aliphatic homopolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. |
| External Descriptors | C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| IUPAC Name | (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
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| INCHI | InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 |
| InChIKey | OMFXVFTZEKFJBZ-HJTSIMOOSA-N |
| Smiles | CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O |
| Isomeric SMILES | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O |
| WGK Germany | 3 |
| RTECS | GM7650000 |
| Molecular Weight | 346.46 |
| Beilstein | 2339601 |
| Reaxy-Rn | 2063664 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2063664&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 18, 2025 | C119329 | |
| Certificate of Analysis | Nov 14, 2024 | C119329 | |
| Certificate of Analysis | Jan 11, 2023 | C119329 | |
| Certificate of Analysis | Dec 09, 2022 | C119329 |
| Solubility | Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water. |
|---|---|
| Specific Rotation[α] | +221 to +226 deg(C=1, EtOH) |
| Melt Point(°C) | 180-183°C |
| Molecular Weight | 346.500 g/mol |
| XLogP3 | 1.900 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 346.214 Da |
| Monoisotopic Mass | 346.214 Da |
| Topological Polar Surface Area | 74.600 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 638.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 7 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Li M et al.. (2017) Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach.. J Neurogastroenterol Motil, 23 (3): (464-476). |
| 2. Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi. (2023) Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway. Frontiers in Bioscience-Landmark, 28 (11): (311). |
| 3. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2024) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, 461 (132477). |
| 4. Junhui He, Dongbo Han, Chunlian Jia, Jiaxiu Xie, Fucui Zhu, Jie Wei, Dongmei Li, Dongmei Wei, Yi Li, Li Tang, Guining Wei, Jing Yan, Yuanming Tong, Lifang Yang, Xuecai Tan. (2023) Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression. Drug Design Development and Therapy, |
| 5. Yuan Baoshi, Shi Kexin, Zha Juanmin, Cai Yujia, Gu Yue, Huang Kai, Yue Wenchang, Zhai Qiaocheng, Ding Ning, Ren Wenyan, He Weiqi, Xu Ying, Wang Tao. (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death & Disease, 14 (1): (1-12). |
| 6. Jun Huang, Bin Chen, Hao Wang, Sheng Hu, Xudong Yu, James Reilly, Zhiming He, Yong You, Xinhua Shu. (2022) Dihydromyricetin Attenuates Depressive-like Behaviors in Mice by Inhibiting the AGE-RAGE Signaling Pathway. Cells, 11 (23): (3730). |
| 7. He Junhui, Li Dongmei, Wei Jie, Wang Sheng, Chu Shifeng, Zhang Zhao, He Fei, Wei Dongmei, Li Yi, Xie Jiaxiu, Lai Kedao, Chen Naihong, Wei Guining. (2022) Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. NEUROCHEMICAL RESEARCH, 47 (12): (3761-3776). |
| 8. Li Sheng, Wang Zhi, Yao Jing Wen, Jiao Hong Chao, Wang Xiao Juan, Lin Hai, Zhao Jing Peng. (2022) Reduced PGC-1β protein expression may underlie corticosterone inhibition of mitochondrial biogenesis and oxidative phosphorylation in chicken muscles. Frontiers in Physiology, 13 |
| 9. Sun Jia-Yi, Liu Yi-Tong, Jiang Sheng-Nan, Guo Peng-Mei, Wu Xin-Yu, Yu Jia. (2022) Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway. Frontiers in Pharmacology, 13 |
| 10. Mingfa Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Haifang Li, Yunlei Zhou, Hai Lin. (2022) Research Note: Creatine monohydrate alleviates protein breakdown induced by corticosterone via inhibiting ubiquitin proteasome pathway in chicken myotubes. POULTRY SCIENCE, 101 (102177). |
| 11. Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao, Luan Shu. (2022) Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling. NUTRITIONAL NEUROSCIENCE, |
| 12. Wang Yan, Zhou Sixu, Song Xujiao, Ding Shanshan, Wang Baogui, Wen Jiangfeng, Chen Chunlin. (2022) Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway. NEUROCHEMICAL RESEARCH, 47 (10): (3126-3136). |
| 13. Chai Yuhui, Cai Yawen, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway. Frontiers in Pharmacology, 13 |
| 14. Jie Liu, Yi Cheng, Yuanjin Zhang, Shengbo Huang, Zongjun Liu, Xin Wang. (2021) Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats. TOXICOLOGY LETTERS, 352 (46). |
| 15. Huina Li, Kefan Wu, Yue Zhang, Ning Li, Kaijin Wang. (2020) Crassifoside H ameliorates depressant behavior in chronic unpredictable mild stress rats by improving HPA axis dysfunction and inhibiting inflammation in hippocampus. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 19 (8): (1693-1699). |
| 16. Lan Zhang, Yue Yang, Lei Di, Jun-long Li, Ning Li. (2020) Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. PHARMACEUTICAL BIOLOGY, 58 (1): (498-509). |
| 17. Jingjing Liu, Ning Xu, Hong Men, Shuang Li, Yanli Lu, Sze Shin Low, Xin Li, Lihang Zhu, Chen Cheng, Gang Xu, Qingjun Liu. (2020) Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System. SENSORS, 20 (5): (1422). |
| 18. Zhang Yingyi, Li Liang, Wang Qi, Shen Mei, Han Weili, Yang Xuemei, Chen Lingyun, Ma Ande, Zhou Zhengzheng. (2019) Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (15): (3361-3372). |
| 19. Li-Tao Yi, Rong-Hao Mu, Shu-Qi Dong, Shuang-Shuang Wang, Cheng-Fu Li, Di Geng, Qing Liu. (2018) miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice. JOURNAL OF PSYCHOPHARMACOLOGY, |
| 20. He Xiaolie, Yang Li, Wang Mei, Zhuang Xizhen, Huang Ruiqi, Zhu Rongrong, Wang Shilong. (2017) Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and Dexanabinol-Loaded Solid Lipid Nanoparticles. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 42 (6): (2281-2294). |
| 21. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu. (2015) Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS. Analytical Methods, 7 (19): (8418-8431). |
| 22. Zhijing Song,Huanyu Gao,Wenchun Xie,Qing Sun,Kai Liang,Yan Li. (2020-12-29) Quantitative MALDI-MS assay of steroid hormones in plasma based on hydroxylamine derivatization.. Analytical biochemistry, 616 (114089-114089). |
| 23. Ang W, Chen G, Xiong L, Chang Y, Pi W, Liu Y, Li C, Zheng J, Zhou L, Yang B, Deng Y, Yang S, Luo Y, Wei Y.. (2014) Synthesis and biological evaluation of novel naphthalene compounds as potential antidepressant agents.. Eur J Med Chem, 82 (263-273). |
| 24. Dainan Yu, Haifeng Wan, Chao Tong, Lu Guang, Gang Chen, Jiali Su, Lan Zhang, Yue Wang, Zhenyu Xiao, Jinglei Zhai, Long Yan, Wenwu Ma, Kun Liang, Taoyan Liu, Yuefan Wang, Zehang Peng, Lanfang Luo, Ruoxuan Yu, Wei Li, Hongbo Qi, Hongmei Wang, Ng Shyh-Chang. (2024) A multi-tissue metabolome atlas of primate pregnancy. CELL, 187 (764-781.e14). |
| 25. Junying Li, Xiaoxiao Shan, Yu Gao, Haizhou Zhu, Hongyan Cheng, Chengjie Xing, Lele Zhou, Wenkang Tao, Yangyang Li, Baoqi Yin, Caiyun Zhang. (2025) Acori Tatarinowii Rhizoma regulates OCT3/OATP2 and P-gp/MRP1 to “guide medicines upwards” in Kai-Xin-San to treat Alzheimer's disease. JOURNAL OF ETHNOPHARMACOLOGY, 343 (119484). |
| 26. Wenshan Yang, Yuanbo Wang, Xia Li, Rui Jing, Lihua Mu, Yuan Hu. (2024) Antidepressive and cardioprotective effects of Kai-xin-san via the regulation of HPA axis dysfunction and lipid metabolism in a rat model of depressive-cardiac disease. BRAIN RESEARCH BULLETIN, 219 (111126). |
| 27. Li Tian, Wei Yao, Jiao Beibie, Hao Rui, Zhou Beibei, Bian Xinlan, Wang Peijuan, Zhou Yahong, Sun Xia, Zhang Jian. (2024) Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism. Frontiers in Pharmacology, 15 |
| 28. Liu Jie, Zhang Ke, Zhao Mindie, Chen Liang, Chen Huimin, Zhao Yulan, Zhao Ruqian. (2024) Dietary bile acids alleviate corticosterone-induced fatty liver and hepatic glucocorticoid receptor suppression in broiler chickens. JOURNAL OF ANIMAL SCIENCE, |
| 29. Dihao Xie, Simin Zhong, Meixue Luo, Jiahao Xu, Ruoyan Zheng, Jiading Luo, Yiting Wang, Yongxing Guo, Lianxia Guo, Baojian Wu, Danyi Lu. (2024) Disruption of local circadian clocks in aristolochic acid-induced nephropathy in mice. PHYTOMEDICINE, 135 (156235). |
| 30. Rui Liu, Xingya Sun, Yingjie Zhang, Peipei Li, Li Nan, Qing Shen, Kai Wen, Xuezhi Yu, Jianzhong Shen, Yantong Pan, Zhanhui Wang. (2024) Highly selective and sensitive immunoassays for flurogestone acetate analysis in goat milk: From rational hapten design and antibody production to assay development. FOOD CHEMISTRY, 449 (139198). |
| 31. Mengru Chen, Yifei He, Yimin Jia, Lei Wu, Ruqian Zhao. (2025) Liver transcriptome response to avian pathogenic Escherichia coli infection in broilers with corticosterone treatment. POULTRY SCIENCE, 104 (105020). |
| 32. Hu Lili, Wu Na, Wang Jue, Cai Donghui. (2025) Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression. Scientific Reports, 15 (1): (1-11). |
| 33. Jia Yanjun, Wang Yanping, Wang Zixia, Zhang Zeyu, Zhang Ju, Zhang Jingjing, Sun Ke, Hua Yongchen, Chai Guolin, Hu Fangdi. (2024) Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway. Frontiers in Pharmacology, 15 |
| 34. Mingyan Wang, Xin Wei, Yugai Jia, Chaonan Wang, Xinliu Wang, Xin Zhang, Depei Li, Yuanyuan Wang, Yonggang Gao. (2024) Quercetin alleviates chronic unpredictable mild stress‐induced depression‐like behavior by inhibiting NMDAR1 with α2δ‐1 in rats. CNS Neuroscience & Therapeutics, 30 (4): (e14724). |
| 35. Qing Zhu, Yuanshan Han, Ying He, Pan Meng, Yilan Fu, Hui Yang, Gefei He, Minghui Long, Yingrui Shi. (2024) Quercetin inhibits neuronal ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression. PHYTOMEDICINE, (155560). |
| 36. Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Liu. (2024) Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling. ACTA NEUROPSYCHIATRICA, (1-11). |