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Cordycepin - 98%, high purity , CAS No.73-03-0

13 Citations COA COA
In stock
Item Number
C110081
Grouped product items
SKU Size
Availability
 Price Qty
C110081-25mg
25mg
2
$9.90
C110081-100mg
100mg
7
$24.90
C110081-500mg
500mg
1
$44.90
C110081-1g
1g
1
$79.90
C110081-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Nucleoside antagonist. Inhibits NF-κB signaling

View related series
Amino Acid/Protein Metabolism (1836) Anti-infection (2803) Antibiotic (1629) Autophagy (1917) Bacterial (3013) Extrinsic Pathway (436) Metabolic Enzyme/Protease (4860) MMP (148) Pyrimidines (539) Six-Membered Heterocyclic Compounds (1696)

Basic Description

Synonyms Cordycepin, from Cordyceps militaris | CORDYCEPIN [MI] | 9-(3-Deoxy-b-D-erythro-pentofuranosyl)-9H-purin-6-amine | Cordycepin, >=98.0% (HPLC) | UNII-GZ8VF4M2J8 | AC-22613 | MFCD00037998 | NSC-63984 | Q2256677 | Z3041517973 | AKOS015854875 | (2R,3R,5S)-2-(
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Nucleoside antagonist, able to interfere with RNA synthesis. Inhibits NF-κB signaling. Anti-inflammatory and antitumor effects in vitro and in vivo .
Source from Cordyceps militaris
Storage Temp Store at 2-8°C,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription.
An anticancer, antifungal nucleoside analog.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Nucleosides, nucleotides, and analogues
Class Purine nucleosides
Subclass Purine 3'-deoxyribonucleosides
Intermediate Tree Nodes Not available
Direct Parent Purine 3'-deoxyribonucleosides
Alternative Parents 6-aminopurines  Aminopyrimidines and derivatives  N-substituted imidazoles  Imidolactams  Tetrahydrofurans  Heteroaromatic compounds  Secondary alcohols  Oxacyclic compounds  Azacyclic compounds  Primary amines  Primary alcohols  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Purine 3'-deoxyribonucleoside - 6-aminopurine - Imidazopyrimidine - Purine - Aminopyrimidine - N-substituted imidazole - Pyrimidine - Imidolactam - Azole - Imidazole - Heteroaromatic compound - Tetrahydrofuran - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Amine - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Alcohol - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as purine 3'-deoxyribonucleosides. These are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 3.
External Descriptors adenosines - 3'-deoxyribonucleoside

Associated Targets(Human)

ADA Tclin Adenosine deaminase (129 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BXPC-3 (2997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MT4 (17854 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THP-1 (11052 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Jurkat (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KG-1 (867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW-620 (52400 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MV4-11 (7307 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TLR4 Tchem Toll-like receptor 4 (970 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RL (305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H929 (451 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEL 92.1.7 (74 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NS5B Hepatitis C virus NS5B RNA-dependent RNA polymerase (3026 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human alphaherpesvirus 2 (4932 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human respirovirus 3 (1674 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vaccinia virus (4609 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human alphaherpesvirus 1 (11089 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Poliovirus 1 (1274 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Semliki Forest virus (705 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sindbis virus (1599 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vesicular stomatitis virus (4460 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Coxsackievirus B4 (2249 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vero (26788 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L929 (3802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rela Transcription factor p65 (175 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mammalian orthoreovirus 1 (1523 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP51 Sterol 14-alpha demethylase (857 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATP-dependent molecular chaperone HSP82 (2186 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TIM23 Mitochondrial import inner membrane translocase subunit TIM23 (781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488180045
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488180045
IUPAC Name (2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
INCHI InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
InChIKey OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Smiles C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO
Isomeric SMILES C1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)N)CO
WGK Germany 3
RTECS AU7358610
UN Number 2811
Molecular Weight 251.24
Beilstein 35194
Reaxy-Rn 7169449
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7169449&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot Number Certificate Type Date Item
E2526627 Certificate of Analysis Mar 15, 2025 C110081
E2514221 Certificate of Analysis Mar 15, 2025 C110081
E2514222 Certificate of Analysis Mar 15, 2025 C110081
G2315439 Certificate of Analysis Jul 21, 2023 C110081
G2315441 Certificate of Analysis Jul 21, 2023 C110081
G2315524 Certificate of Analysis Jul 21, 2023 C110081
G2315527 Certificate of Analysis Jul 21, 2023 C110081
K2422321 Certificate of Analysis Jul 06, 2023 C110081
I2321107 Certificate of Analysis Jul 06, 2023 C110081
I2321091 Certificate of Analysis Jul 06, 2023 C110081
I2321092 Certificate of Analysis Jul 06, 2023 C110081
F2415067 Certificate of Analysis Jul 06, 2023 C110081
B2328537 Certificate of Analysis Feb 04, 2023 C110081
B2328530 Certificate of Analysis Feb 04, 2023 C110081
B2328526 Certificate of Analysis Feb 04, 2023 C110081
B2328543 Certificate of Analysis Feb 04, 2023 C110081
B2328538 Certificate of Analysis Feb 04, 2023 C110081
B2225352 Certificate of Analysis Dec 15, 2021 C110081
B2225372 Certificate of Analysis Dec 15, 2021 C110081
B2225370 Certificate of Analysis Dec 15, 2021 C110081
B2225371 Certificate of Analysis Dec 15, 2021 C110081

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Chemical and Physical Properties

Solubility Soluble in DMSO (100 mM), methanol, and water
Sensitivity heat sensitive;Moisture sensitive
Specific Rotation[α] -46° (C=1,H2O)
Melt Point(°C) 224-228°C
Molecular Weight 251.240 g/mol
XLogP3 -1.200
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 2
Exact Mass 251.102 Da
Monoisotopic Mass 251.102 Da
Topological Polar Surface Area 119.000 Ų
Heavy Atom Count 18
Formal Charge 0
Complexity 307.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao.  (2023)  Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway.  BIOMEDICINE & PHARMACOTHERAPY,  163  (114776). 
2. Xinyue Li, Yuanyuan Fan, Zhengbao Zha, Deyan Gong, Jiajia Yu, Qianhui Li, Ruoyao Li, Hua Wang, Fei Wang.  (2023)  Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation.  ADVANCED FUNCTIONAL MATERIALS,  33  (18): (2214059). 
3. Ya Chen, Yuan Jiang, Xinyu Huang, Lin Chen, Hao Yang, Jian Zhao, Beibei Liang.  (2022)  Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis.  Evidence-based Complementary and Alternative Medicine,  2022  (6454482). 
4. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang.  (2022)  Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans.  Infection and Drug Resistance,     
5. Weng Chunyue, Mi Zheyan, Li Meijing, Qin Haibin, Hu Zhongce, Liu Zhiqiang, Zheng Yuguo, Wang Yuanshan.  (2022)  Improvement of S-adenosyl-L-methionine production in Saccharomyces cerevisiae by atmospheric and room temperature plasma-ultraviolet compound mutagenesis and droplet microfluidic adaptive evolution.  3 Biotech,  12  (9): (1-15). 
6. Huizhen Sun, Anyong Zhang, Yanchun Gong, Wei Sun, Baiyi Yan, Shuihong Lei, Li-Hua Yao.  (2022)  Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged INS-1 cells.  EUROPEAN JOURNAL OF PHARMACOLOGY,  920  (174843). 
7. Jing Yang, Yiwen Zhou, Jinsong Shi.  (2020)  Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK.  LIFE SCIENCES,  251  (117645). 
8. Hao Song, Li-Ping Huang, Yuping Li, Chao Liu, Songhua Wang, Wei Meng, Shanshan Wei, Xin-Ping Liu, Yanchun Gong, Li-Hua Yao.  (2018)  Neuroprotective effects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons.  NEUROTOXICOLOGY,  68  (73). 
9. Qi Yize, Zhou Yao, Li Jiyang, Zhu Fangyuan, Guo Gengni, Wang Can, Yu Man, Wang Yijie, Ma Tengfei, Feng Shanwu, Zhou Li.  (2024)  3′-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.  Neural Regeneration Research,  19  (10): (2270). 
10. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.  (2025)  An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds.  FOOD CHEMISTRY,    (143873). 
11. Zhu Liang, Keyan Zhang, Hongli Guo, Xujiao Tang, Mingzhu Chen, Jinsong Shi, Jing Yang.  (2024)  Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence.  INTERNATIONAL IMMUNOPHARMACOLOGY,  132  (111981). 
12. Chen Ya, Zhu Congcong, Tai Zongguang, Lian Tianyan, Zhu Quangang, Chen Zhongjian.  (2024)  Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop.  MOLECULAR BIOTECHNOLOGY,    (1-12). 
13. Huizhen Sun, Shanshan Wei, Yanchun Gong, Kaizhi Ding, Shan Tang, Wei Sun, Chunhua Yuan, Liping Huang, Zhibing Liu, Chong Chen, Lihua Yao.  (2024)  Neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons.  CELL STRESS & CHAPERONES,     

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