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Compound 48/80 trihydrochloride - 98%, high purity , CAS No.848035-21-2

COA

Grade & Purity:

≥98%

Cas Number: 848035-21-2
Molecular Weight: 629.10
PubChem CID: 118797323

In stock

Item Number

C649326

Grouped product items
SKU	Size	Availability	Price	Qty
C649326-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$110.90
C649326-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90

View related series

Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) Phospholipase (108)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl- p -methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl- p -methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets . In Vitro Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. ?\nCompound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 7-week-old Wistar male rats (fasted for 24 hours)Dosage: 0.75 mg/kg Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter. Form:Solid

Names and Identifiers

IUPAC Name	2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride
INCHI	InChI=1S/C32H45N3O3.3ClH/c1-33-14-11-23-7-9-30(36-4)26(17-23)21-28-19-25(13-16-35-3)20-29(32(28)38-6)22-27-18-24(12-15-34-2)8-10-31(27)37-5;;;/h7-10,17-20,33-35H,11-16,21-22H2,1-6H3;3*1H
InChIKey	KIAWAQJORBNOIF-UHFFFAOYSA-N
Smiles	CNCCC1=CC(=C(C=C1)OC)CC2=CC(=CC(=C2OC)CC3=C(C=CC(=C3)CCNC)OC)CCNC.Cl.Cl.Cl
PubChem CID	118797323
Molecular Weight	629.10

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	H2O : 25 mg/mL (39.74 mM; Need ultrasonic) DMSO : 10 mg/mL (15.90 mM; ultrasonic and warming and heat to 60°C)

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