Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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C106740-500mg
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500mg |
3
|
$89.90
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C106740-1g
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1g |
3
|
$159.90
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C106740-5g
|
5g |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$489.90
|
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| Synonyms | Colchicum autumnale | Colcin | Colchisol | Colchineos |
|---|---|
| Specifications & Purity | Moligand™, for plant cell culture, ≥98%(HPLC) |
| Biochemical and Physiological Mechanisms | Colchicine interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicine may be useful for treating acute coronary syndromes. It is p |
| Storage Temp | Protected from light,Argon charged,Desiccated |
| Shipped In | Normal |
| Grade | for plant cell culture, Moligand™ |
| Action Type | AGONIST, ANTAGONIST, INHIBITOR |
| Mechanism of action | Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I |
| Product Description |
Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C.
|
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Hydrocarbon derivatives |
| Class | Tropones |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Tropones |
| Alternative Parents | Anisoles Alkyl aryl ethers Cyclic ketones Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Organopnictogen compounds Organonitrogen compounds Organic oxides |
| Molecular Framework | Aromatic homopolycyclic compounds |
| Substituents | Anisole - Tropone - Alkyl aryl ether - Benzenoid - Cyclic ketone - Carboximidic acid - Carboximidic acid derivative - Ether - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Aromatic homopolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as tropones. These are compounds containing a tropone ring, which is a cycloheptatrienone ring bearing a ketone group. |
| External Descriptors | Alkaloids - Isoquinoline alkaloids |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504751015 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504751015 |
| IUPAC Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
| INCHI | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| InChIKey | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
| Smiles | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| Isomeric SMILES | CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| WGK Germany | 3 |
| RTECS | GH0700000 |
| UN Number | 1544 |
| Packing Group | I |
| Molecular Weight | 399.44 |
| Beilstein | 2228813 |
| Reaxy-Rn | 2228812 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2228812&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 13, 2025 | C106740 | |
| Certificate of Analysis | Apr 25, 2025 | C106740 | |
| Certificate of Analysis | Apr 25, 2025 | C106740 | |
| Certificate of Analysis | Apr 25, 2025 | C106740 | |
| Certificate of Analysis | Mar 05, 2025 | C106740 | |
| Certificate of Analysis | Oct 30, 2024 | C106740 | |
| Certificate of Analysis | Oct 30, 2024 | C106740 | |
| Certificate of Analysis | Oct 30, 2024 | C106740 | |
| Certificate of Analysis | Apr 03, 2024 | C106740 | |
| Certificate of Analysis | Jun 06, 2023 | C106740 | |
| Certificate of Analysis | Jun 06, 2023 | C106740 | |
| Certificate of Analysis | Jun 06, 2023 | C106740 | |
| Certificate of Analysis | Mar 14, 2022 | C106740 |
| Solubility | Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol., Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol. |
|---|---|
| Sensitivity | Light sensitive.Moisture sensitive |
| Specific Rotation[α] | -238° (C=1,EtOH) |
| Melt Point(°C) | 150-160°C |
| Molecular Weight | 399.400 g/mol |
| XLogP3 | 1.000 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 399.168 Da |
| Monoisotopic Mass | 399.168 Da |
| Topological Polar Surface Area | 83.100 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 740.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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