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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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C111044-250mg
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250mg |
3
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$48.90
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C111044-1g
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1g |
2
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$162.90
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C111044-5g
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5g |
2
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$238.90
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C111044-25g
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25g |
1
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$1,075.90
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C111044-100g
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100g |
2
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$3,871.90
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Antioxidant
| Synonyms | all-trans-ubiquinone | EJ27X76M46 | NCGC00159429-02 | Aqua Q10 | Luvacor | NSC 140865 | Ubiquinone 50 | Q-Gel 100 | Ubidecarenone [INN:BAN:JAN:NF] | UBIDECARENONE [MART.] | Ubidecarenonum [Latin] | 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27 |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity. Ferroptosis inhibitor. |
| Storage Temp | Store at -20°C,Argon charged |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
Application It is used as a component of electron transport chain and in aerobic cellular respiration, Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS and up-regulation of NOS2. As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Prenol lipids |
| Subclass | Quinone and hydroquinone lipids |
| Intermediate Tree Nodes | Prenylquinones |
| Direct Parent | Ubiquinones |
| Alternative Parents | Polyterpenoids Polyprenylbenzoquinones P-benzoquinones Vinylogous esters Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic homomonocyclic compounds |
| Substituents | Polyterpenoid - Polyprenylbenzoquinone - Ubiquinone skeleton - Quinone - P-benzoquinone - Vinylogous ester - Cyclic ketone - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as ubiquinones. These are coenzyme Q derivatives containing a 5, 6-dimethoxy-3-methyl(1,4-benzoquinone) moiety to which an isoprenyl group is attached at ring position 2(or 6). |
| External Descriptors | Ubiquinones |
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| ALogP | 19.4 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| IUPAC Name | 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione |
|---|---|
| INCHI | InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ |
| InChIKey | ACTIUHUUMQJHFO-UPTCCGCDSA-N |
| Smiles | CC1=C(C(=O)C(=C(C1=O)OC)OC)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C |
| Isomeric SMILES | CC1=C(C(=O)C(=C(C1=O)OC)OC)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C |
| WGK Germany | 3 |
| RTECS | DK3900000 |
| Molecular Weight | 863.34 |
| Beilstein | 1900141 |
| Reaxy-Rn | 1900140 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1900140&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 05, 2025 | C111044 | |
| Certificate of Analysis | May 27, 2025 | C111044 | |
| Certificate of Analysis | May 15, 2025 | C111044 | |
| Certificate of Analysis | Dec 09, 2024 | C111044 | |
| Certificate of Analysis | Aug 29, 2024 | C111044 | |
| Certificate of Analysis | Aug 22, 2024 | C111044 | |
| Certificate of Analysis | Aug 22, 2024 | C111044 | |
| Certificate of Analysis | Aug 22, 2024 | C111044 | |
| Certificate of Analysis | Aug 22, 2024 | C111044 | |
| Certificate of Analysis | Aug 20, 2024 | C111044 | |
| Certificate of Analysis | Mar 30, 2024 | C111044 | |
| Certificate of Analysis | Aug 21, 2023 | C111044 | |
| Certificate of Analysis | Aug 21, 2023 | C111044 | |
| Certificate of Analysis | Aug 21, 2023 | C111044 | |
| Certificate of Analysis | Aug 21, 2023 | C111044 | |
| Certificate of Analysis | Aug 21, 2023 | C111044 | |
| Certificate of Analysis | Aug 21, 2023 | C111044 | |
| Certificate of Analysis | Sep 21, 2022 | C111044 | |
| Certificate of Analysis | Sep 21, 2022 | C111044 | |
| Certificate of Analysis | Sep 21, 2022 | C111044 | |
| Certificate of Analysis | Aug 03, 2022 | C111044 |
| Solubility | Solvent:ethanol, Max Conc. mg/mL: 4.32, Max Conc. mM: 5 with gentle warming; Solvent:chloroform, Max Conc. mg/mL: 43.17, Max Conc. mM: 50 |
|---|---|
| Sensitivity | Light Sensitive,Air Sensitive,Heat Sensitive |
| Melt Point(°C) | 49°C |
| Molecular Weight | 863.300 g/mol |
| XLogP3 | 19.400 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 31 |
| Exact Mass | 862.684 Da |
| Monoisotopic Mass | 862.684 Da |
| Topological Polar Surface Area | 52.600 Ų |
| Heavy Atom Count | 63 |
| Formal Charge | 0 |
| Complexity | 1840.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 9 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 9 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yuan Shun, Che Yanjia, Wang Zhiwei, Xing Kai, Xie Xiaoping, Chen Yuanyang. (2023) Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation. Journal of Translational Medicine, 21 (1): (1-23). |
| 2. Xiang Luo, Sha Ao, Hongze Wu, David Julian McClements, Likun Fang, Mengyu Huang, Yanyan Zhou, Xuguang Yin, Meiyang Xi, Tao Cai, Kewu Zhu. (2023) Hyaluronic Acid Poly(glyceryl)10-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (29): (11180–11194). |
| 3. Tiantian Chen, Yan Qin, Yao Li, Yaru Li, Jiajia Luo, Lanlan Fan, Meiyu Feng, Zheng Wang, Yanjun Zhao. (2023) Chiral Polymer Micelles Alleviate Adriamycin Cardiotoxicity via Iron Chelation and Ferroptosis Inhibition. ADVANCED FUNCTIONAL MATERIALS, (2300689). |
| 4. Shuoye Yang, Yakun Niu, Siqi Li, Mingzhen Lv, Jiaxin Liu, Lu Zhang, Lan Cui, Lingbo Qu. (2023) TPGS and Doca dual-modified mesoporous silica nanoparticle-supported lipid bilayers enhance the efficient delivery and in vivo absorption of Coenzyme Q10. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 81 (104243). |
| 5. Xuan Ma, Hui Chen, Lixing Cao, Shuang Zhao, Chong Zhao, Shutao Yin, Lihong Fan, Hongbo Hu. (2022) 18β-glycyrrhetinic acid protects neuronal cells from ferroptosis through inhibiting labile iron accumulation and preventing coenzyme Q10 reduction. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 635 (57). |
| 6. Yaqin Wang, Lingjia Fan, Jintao Huang, Jingjing Liang, Xingnan Wang, Yichen Ren, Hongcai Li, Tianli Yue, Zhenpeng Gao. (2023) Evaluation of chemical composition, antioxidant activity, and gut microbiota associated with pumpkin juice fermented by Rhodobacter sphaeroides. FOOD CHEMISTRY, 401 (134122). |
| 7. Mohsen Sheykhhasan, Razieh Amini, Sara Soleimani Asl, Massoud Saidijam, Seyed Mahmoud Hashemi, Rezvan Najafi. (2022) Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease. BIOMEDICINE & PHARMACOTHERAPY, 152 (113224). |
| 8. Yuan Liu, Yaxin Yao, Wenjing Tao, Feng Liu, Songbai Yang, Ayong Zhao, Dan Song, Xiangchen Li. (2021) Coenzyme Q10 ameliorates BPA-induced apoptosis by regulating autophagy-related lysosomal pathways. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 221 (112450). |
| 9. Yang Shuoye, Niu Yakun, Li Luheng, Liu Jiaxin, Ma Mengjin, Duan Xiaoyu, Zhang Lu, Wang Le, Qu Lingbo. (2021) PEG-conjugated single-walled carbon nanotubes enhance the cellular uptake of Coenzyme Q10: in vitro evaluation and mechanism study. JOURNAL OF NANOPARTICLE RESEARCH, 23 (5): (1-14). |
| 10. Peiwen Zhang, Shen Chen, Huanwen Tang, Wanjun Fang, Ke Chen, Xu Chen. (2021) CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy. TOXICOLOGY AND APPLIED PHARMACOLOGY, 410 (115355). |
| 11. Wenqi Cao, Linfan Shi, Gengxin Hao, Jun Chen, Wuyin Weng. (2021) Effect of molecular weight on the emulsion properties of microfluidized gelatin hydrolysates. FOOD HYDROCOLLOIDS, 111 (106267). |
| 12. Meng Jiang, Xiong Zheng, Yinguang Chen. (2020) Enhancement of denitrification performance with reduction of nitrite accumulation and N2O emission by Shewanella oneidensis MR-1 in microbial denitrifying process. WATER RESEARCH, 169 (115242). |
| 13. Liu Ze, Li Zonglin, Wu Ya’Nan, Song Shaohui, Yang Huijuan, Cai Wei, Weidong Li, Guoyang Liao. (2019) Application of a novel nanoemulsion adjuvant for rabies vaccine which stabilizes a Krebs cycle intermediate (SDH) in an animal model. Human Vaccines & Immunotherapeutics, 15 (2): (388-396). |
| 14. Shuoye Yang. (2017) Preparation, in vitro Characterization and Pharmacokinetic Study of Coenzyme Q10 Long-Circulating Liposomes. Drug Research, 68 (5): (270-279). |
| 15. Ting Yue, He-Lin Xu, Pian-Pian Chen, Lei Zheng, Qun Huang, Wen-Shuang Sheng, Yuan-Di Zhuang, Li-Zhuo Jiao, Ting-Ting Chi, De-Li ZhuGe, Jin-Jin Liu, Ying-Zheng Zhao, Li Lan. (2017) Combination of coenzyme Q10-loaded liposomes with ultrasound targeted microbubbles destruction (UTMD) for early theranostics of diabetic nephropathy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 528 (664). |
| 16. Huibin Li, Fang Chen. (2017) Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 24 (797). |
| 17. Peng Xin, Sun Yinhe, Qi Wei, Su Rongxin, He Zhimin. (2014) Study of the Interaction Between Coenzyme Q10 and Human Serum Albumin: Spectroscopic Approach. JOURNAL OF SOLUTION CHEMISTRY, 43 (3): (585-607). |
| 18. Xiaoling Lin, Meier Chen, Pedro Rodriguez Gonzalez, Dganit Danino, Harold Corke. (2024) Advancing coenzyme Q10 delivery with plant protein-based nanoparticle-mediated nanosuspensions. FOOD RESEARCH INTERNATIONAL, (115120). |
| 19. Zheng Delu, Cui Chenli, Ye Chengsong, Shao Chen, Zha Xiujing, Xu Ying, Liu Xu, Wang Can. (2024) Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 57 (e13474). |
| 20. Bo Yang, Xu Zhang, Liguo Zhang, Jinjin Wu, Wei Wang, Qiaomei Huang, Zhenyuan Wang, Jichuan Zhang, Tongjie Xu, Chengyu Wu, Jiaheng Zhang. (2024) Ionic Liquid-Based Grapeseed Oil Emulsion for Enhanced Anti-Wrinkle Treatment. Pharmaceuticals, 17 (10): (1273). |
| 21. Haiyan Zhu, Yijing Yang, Yenan Duan, Xin Zheng, Zixiong Lin, Jie Zhou. (2024) Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 759 (110100). |
| 22. Zhou Qu, Yanni Liu, Haoran Wang, Qianxi Yang, Hongwei Fan, Hong Meng. (2025) One-dimensional confinement-induced MOF-in-COF layer on polymeric substrate for helium separation. SEPARATION AND PURIFICATION TECHNOLOGY, 366 (132782). |
| 23. Zhili Xu, Fan Zhang, Dewei Cheng, Qianyun Ma, Wenxiu Wang, Jie Wang, Jianfeng Sun. (2025) Physical stability of oil-in-water multi-layered coenzyme Q10 nano-emulsions. FOOD CHEMISTRY, 464 (141860). |
| 24. Ning Xia, Fengli Gao, Gang Liu, Yong Chang, Lin Liu. (2025) Pyrroloquinoline quinone exhibiting peroxidase-mimicking property for colorimetric assays. ANALYTICA CHIMICA ACTA, 1335 (343468). |
| 25. Mengcheng Jin, Tangbin Zou, Hairong Huang, Ming Chen, Haoqi Zou, Baoyan Chen, Chengze Lai, Huawen Li, Peiwen Zhang. (2024) The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation. MOLECULAR NUTRITION & FOOD RESEARCH, (2400147). |