Skip to the beginning of the images gallery

Co 101244 hydrochloride - ≥99%(HPLC), high purity , CAS No.193356-17-1

COA

Grade & Purity:

≥99%(HPLC)

Cas Number: 193356-17-1
Molecular Weight: 377.9
PubChem CID: 6918426
PubChem SID: 488195877

In stock

Item Number

C288405

Grouped product items
SKU	Size	Availability	Price
C288405-5mg	5mg	5	$117.90
C288405-10mg	10mg	5	$192.90
C288405-25mg	25mg	3	$385.90
C288405-50mg	50mg	3	$612.90
C288405-100mg	100mg	3	$979.90

GluN2B-selective NMDA antagonist

View related series

Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320)

Basic Description

Synonyms	PD 174494, Ro 63-1908 \| 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride \| 1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol hydrochloride
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC50values are 0.043, > 100 and > 100μM for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprot
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines
    - Subclass Benzylpiperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Benzylpiperidines
Intermediate Tree Nodes	Not available
Direct Parent	4-benzylpiperidines
Alternative Parents	4-alkoxyphenols Phenoxy compounds Phenol ethers Toluenes Aralkylamines Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Tertiary alcohols Trialkylamines Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	4-benzylpiperidine - 4-alkoxyphenol - Phenoxy compound - Phenol ether - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Aralkylamine - Toluene - Monocyclic benzene moiety - Benzenoid - Tertiary alcohol - Tertiary aliphatic amine - Tertiary amine - Ether - Azacycle - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Alcohol - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrochloride - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 4-benzylpiperidines. These are organic compounds containing a benzyl group attached to the 4-position of a piperidine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488195877
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195877
IUPAC Name	1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]piperidin-4-ol;hydrochloride
INCHI	InChI=1S/C21H27NO3.ClH/c1-17-2-4-18(5-3-17)16-21(24)10-12-22(13-11-21)14-15-25-20-8-6-19(23)7-9-20;/h2-9,23-24H,10-16H2,1H3;1H
InChIKey	WFFZHKKSIDENAJ-UHFFFAOYSA-N
Smiles	CC1=CC=C(C=C1)CC2(CCN(CC2)CCOC3=CC=C(C=C3)O)O.Cl
Isomeric SMILES	CC1=CC=C(C=C1)CC2(CCN(CC2)CCOC3=CC=C(C=C3)O)O.Cl
Molecular Weight	377.9
Reaxy-Rn	8458032
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8458032&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
D23081120	Certificate of Analysis	Feb 24, 2023	C288405
D2308851	Certificate of Analysis	Feb 24, 2023	C288405
D2308846	Certificate of Analysis	Feb 24, 2023	C288405
D2308861	Certificate of Analysis	Feb 24, 2023	C288405
D2308865	Certificate of Analysis	Feb 24, 2023	C288405
D2308845	Certificate of Analysis	Feb 24, 2023	C288405
D2308850	Certificate of Analysis	Feb 24, 2023	C288405
D2308856	Certificate of Analysis	Feb 24, 2023	C288405
D2308849	Certificate of Analysis	Feb 24, 2023	C288405
D2308848	Certificate of Analysis	Feb 24, 2023	C288405

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 37.79, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 18.9, Max Conc. mM: 50
Molecular Weight	377.900 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	377.176 Da
Monoisotopic Mass	377.176 Da
Topological Polar Surface Area	52.900 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	379.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration