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CNQX - ≥98%, high purity , CAS No.115066-14-3, Antagonist of GluA1;Antagonist of GluA2;GluA3;GluA4

6 Citations COA COA
In stock
Item Number
C131944
Grouped product items
SKU Size
Availability
 Price Qty
C131944-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
C131944-5mg
5mg
2
$48.90
C131944-25mg
25mg
2
$147.90
C131944-100mg
100mg
3
$375.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

AMPA / kainate antagonist

View related series
GluA1 Antagonist (6) GluA2 Antagonist (9) GluA3 (3) GluA4 (2) Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320)

Basic Description

Synonyms 6-cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione | BRD-K53545112-304-01-6 | EX-A5681 | GTPL5475 | 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE | [3H]CNQX | CNQX | 6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo- | Biomol-NT_000200 | BRD-K19438463-0
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Potent, competitive AMPA/kainate glutamate receptor antagonist.Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of GluA1;Antagonist of GluA2;GluA3;GluA4
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazanaphthalenes
Subclass Benzodiazines
Intermediate Tree Nodes Not available
Direct Parent Quinoxalines
Alternative Parents Nitroaromatic compounds  Pyrazines  Benzenoids  Heteroaromatic compounds  Lactams  Propargyl-type 1,3-dipolar organic compounds  Organic oxoazanium compounds  Nitriles  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinoxaline - Nitroaromatic compound - Pyrazine - Benzenoid - Heteroaromatic compound - Lactam - C-nitro compound - Organic nitro compound - Carbonitrile - Nitrile - Organic oxoazanium - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Azacycle - Organooxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
External Descriptors quinoxaline derivative

Associated Targets(Human)

GRIA4 Tclin Glutamate receptor 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GRIA2 Tclin Glutamate receptor 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GRIA3 Tclin Glutamate receptor 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GRIA1 Tclin Glutamate receptor 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIA4 Tclin Glutamate receptor ionotropic AMPA (265 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504762687
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504762687
IUPAC Name 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
INCHI InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChIKey RPXVIAFEQBNEAX-UHFFFAOYSA-N
Smiles C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
Isomeric SMILES C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
WGK Germany 3
Alternate CAS 115066-14-3
MeSH Entry Terms 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6 Cyano 2,3 dihydroxy 7 nitroquinoxaline;6 Cyano 7 nitroquinoxaline 2,3 dione;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX;FG 9065;FG-9065;FG9065
Molecular Weight 232.15
Reaxy-Rn 5821072
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5821072&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
A2509194 Certificate of Analysis Apr 24, 2024 C131944
A2509193 Certificate of Analysis Apr 23, 2024 C131944
H1624071 Certificate of Analysis Feb 18, 2024 C131944
A2213363 Certificate of Analysis Oct 20, 2023 C131944
A2213378 Certificate of Analysis Oct 20, 2023 C131944
A2213380 Certificate of Analysis Oct 20, 2023 C131944

Chemical and Physical Properties

Sensitivity light sensitive
Molecular Weight 232.150 g/mol
XLogP3 0.000
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 0
Exact Mass 232.023 Da
Monoisotopic Mass 232.023 Da
Topological Polar Surface Area 128.000 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 434.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Huijun Li, Xin Xu, Jiwei Wang, Xuefeng Han, Zhouqing Xu.  (2021)  A Robust PVDF-Assisted Composite Membrane for Tetracycline Degradation in Emulsion and Oil-Water Separation.  Nanomaterials,  11  (12): (3201). 
2. Shuling Shen, Junjie Wang, Zhujun Wu, Zheng Du, Zhihong Tang, Junhe Yang.  (2020)  Graphene Quantum Dots with High Yield and High Quality Synthesized from Low Cost Precursor of Aphanitic Graphite.  Nanomaterials,  10  (2): (375). 
3. Zhicheng Wang, Shuping Nie, Ru Xia, Yang Lv, Ming Cao, Ming Chen, Qiannian Dong, Lifen Su, Peng Chen, Bin Yang, Jibin Miao, Zhengzhi Zheng, Jiasheng Qian.  (2018)  Preparation of the Yellow-Colored Aluminum Pigments with Double-Layer Structure Using a Crosslinked Copolymeric Dye.  Polymers,  10  (10): (1097). 
4. Juan Li, Zhen Li, Yanbo Liu, Yijing Li, Yanqiong Wu, Anne Manyande, Zhixiao Li, Hongbing Xiang.  (2024)  Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets.  iScience,  27  (111274). 
5. Huanhuan Gao, Hui Liu, Peihui Xu, Jianzhong Liu.  (2024)  Micro-explosion-induced combustion and agglomeration characteristics in composite propellants with fluorinated graphene.  ACTA ASTRONAUTICA,  225  (489). 
6. Wei Du, Xiaomin Zhang, Songze Li, Xin Xie.  (2024)  Novel Perspective on Sevoflurane-Induced Cognitive Dysfunction: Implications of Neuronal SIRPα and Microglial Synaptic Remodeling.  ACS Chemical Neuroscience,  15  (24): (4500-4516). 

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