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CMP-5 - 95%, high purity , CAS No.880813-42-3

COA

Grade & Purity:

≥95%

Cas Number: 880813-42-3
Molecular Weight: 315.41
PubChem CID: 4722595

In stock

Item Number

C647447

Grouped product items
SKU	Size	Availability	Price
C647447-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$120.90
C647447-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
C647447-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90

View related series

Epigenetics (1496) Histone Methyltransferase (190) Histone Modification (1379)

Basic Description

Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1 , PRMT4 , and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Eps
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1 , PRMT4 , and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected In Vitro CMP-5 (0-100 μM; 24-72 hours) is selectively toxic to lymphoma cells, but shows a limited toxicity to normal resting B lymphocytes even after prolonged incubation. CMP-5 (40 μM; 24 hours) decreases p-BTK and pY(416)SRC expression in 60A cells when it compares to the DMSO-treated group. CMP-5 (0-40 μM; 24 hours) preferentially suppresses the proliferation of human Th1 cells over Th2 cells (43 versus 9% inhibition, respectively). The sensitivity of Th1 cells over Th2 cells to PRMT5 inhibition is different, the IC 50 values are 26.9 μM and 31.6 μM in human Th1 cells and Th2 cells, respectively. CMP-5 (25 μM; 24 hours) alone inhibits mouse Th1 cell proliferation by 91%, when added different doses IL-2, IL-2 enhances proliferation and reaches a peak at 5 ng/ml. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: 60A cells Concentration: 40 μM Incubation Time: 24 hours Result: Inhibited p-BTK and pY(416)SRC protein level. Cell Viability AssayCell Line: Human Th1 cells and Th2 cells Concentration: 25 μM Incubation Time: 24 hours Result: Inhibited mouse Th1 cell proliferation, but addition of IL-2 dose-dependently increased cell proliferation. Form:Oil IC50& Target:IC50: 3.7 μM (mTh1 cells), 9.2 μM (mTh2 cells) IC50: 26.9 μM (hTh1 cells), 31.6 μM (hTh2 cells)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Carbazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Carbazoles
Intermediate Tree Nodes	Not available
Direct Parent	Carbazoles
Alternative Parents	N-alkylindoles Indoles 2-pyridylmethylamines Aralkylamines Substituted pyrroles Benzenoids Heteroaromatic compounds Dialkylamines Azacyclic compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Carbazole - N-alkylindole - Indole - 2-pyridylmethylamine - Aralkylamine - Pyridine - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Secondary amine - Secondary aliphatic amine - Azacycle - Amine - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as carbazoles. These are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-(9-ethylcarbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine
INCHI	InChI=1S/C21H21N3/c1-2-24-20-9-4-3-8-18(20)19-13-16(10-11-21(19)24)14-22-15-17-7-5-6-12-23-17/h3-13,22H,2,14-15H2,1H3
InChIKey	YPJMOVVQKBFRNH-UHFFFAOYSA-N
Smiles	CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=N3)C4=CC=CC=C41
Isomeric SMILES	CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=N3)C4=CC=CC=C41
PubChem CID	4722595
Molecular Weight	315.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 125 mg/mL (396.31 mM; Need ultrasonic)
Molecular Weight	315.400 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	315.174 Da
Monoisotopic Mass	315.174 Da
Topological Polar Surface Area	29.900 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	399.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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