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ClozapineN-oxide dihydrochloride - ≥98%, high purity , CAS No.2250025-93-3

COA

Grade & Purity:

≥98%

Cas Number: 2250025-93-3
Molecular Weight: 415.74
PubChem CID: 137187247
PubChem SID: 504773483

In stock

Item Number

C287498

Grouped product items
SKU	Size	Availability	Price
C287498-5mg	5mg	7	$56.90
C287498-10mg	10mg	5	$93.90
C287498-25mg	25mg	4	$211.90
C287498-50mg	50mg	4	$380.90
C287498-100mg	100mg	4	$685.90

Activator of hM3Dqand hM4DiDREADDs; water soluble version ofClozapineN-oxide

View related series

Class A GPCR (4138) Dopamine Receptor (237) Drug Metabolite (241) GPCR/G Protein (3172) mAChR (182) Metabolic Enzyme/Protease (4860) Metabolite (5307) Neuronal Signaling (3320)

Basic Description

Synonyms	CNO (water-soluble) \| 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Water soluble salt of Clozapine N-oxide. Activator of muscarinic DREADDs. Exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Pubchem Sid	504773483
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773483
IUPAC Name	3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine;dihydrochloride
INCHI	InChI=1S/C18H19ClN4O.2ClH/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18;;/h2-7,12,20H,8-11H2,1H3;2*1H
InChIKey	MBRGKRXDVKTUPT-UHFFFAOYSA-N
Smiles	C[N+]1(CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)[O-].Cl.Cl
PubChem CID	137187247
Molecular Weight	415.74

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
F23091042	Certificate of Analysis	May 12, 2023	C287498
F23091043	Certificate of Analysis	May 12, 2023	C287498
F23091044	Certificate of Analysis	May 12, 2023	C287498
F23091045	Certificate of Analysis	May 12, 2023	C287498
F23091046	Certificate of Analysis	May 12, 2023	C287498
F23091048	Certificate of Analysis	May 12, 2023	C287498
F23091051	Certificate of Analysis	May 12, 2023	C287498
F23091047	Certificate of Analysis	May 12, 2023	C287498
F23091049	Certificate of Analysis	May 12, 2023	C287498
F23091050	Certificate of Analysis	May 12, 2023	C287498

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 41.57, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 41.57, Max Conc. mM: 100

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