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Clascoterone - 99%, high purity , Androgen Receptor antagonist, CAS No.19608-29-8, Androgen Receptor antagonist

1 Citations

COA

Grade & Purity:

Moligand™

≥99%

Cas Number: 19608-29-8
Molecular Weight: 402.52
PubChem CID: 11750009
PubChem SID: 504766703

In stock

Item Number

C413669

Grouped product items
SKU	Size	Availability	Price
C413669-5mg	5mg	3	$13.90
C413669-25mg	25mg	3	$56.90
C413669-100mg	100mg	3	$187.90
C413669-500mg	500mg	2	$543.90

Androgen Receptor Antagonists

View related series

Androgen Receptor (133) Androgen receptor Antagonist (15) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Synonyms	Cortodoxone 17.alpha.-propionate \| XN7MM8XG2M \| EX-A1953 \| clascoterone; 19608-29-8; cb-03-1 \| DB12499 \| CLASCOTERONE [INN] \| AM20030275 \| BCP9000144 \| Winlevi \| (8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Androgen Receptor antagonist
Product Description	Information Clascoterone Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR) . Targets AR

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Steroids and steroid derivatives
    - Subclass Hydroxysteroids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Steroids and steroid derivatives
Subclass	Hydroxysteroids
Intermediate Tree Nodes	Not available
Direct Parent	21-hydroxysteroids
Alternative Parents	Gluco/mineralocorticoids, progestogins and derivatives Steroid esters 20-oxosteroids 3-oxo delta-4-steroids Delta-4-steroids Cyclohexenones Alpha-acyloxy ketones Alpha-hydroxy ketones Carboxylic acid esters Monocarboxylic acids and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic homopolycyclic compounds
Substituents	Progestogin-skeleton - 21-hydroxysteroid - Pregnane-skeleton - Steroid ester - 20-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - Oxosteroid - Delta-4-steroid - Cyclohexenone - Alpha-acyloxy ketone - Alpha-hydroxy ketone - Cyclic ketone - Carboxylic acid ester - Ketone - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Primary alcohol - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Alcohol - Organooxygen compound - Organic oxide - Aliphatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.498
HBD Count	1
Rotatable Bond	5

Associated Targets(Human)

AR Tclin Androgen receptor (2 Activities)

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Skin (286 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Syrian golden hamster (1610 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Srd5a1 Steroid 5-alpha-reductase (312 Activities)

Discover Target: Srd5a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504766703
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766703
IUPAC Name	[(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
INCHI	InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1
InChIKey	GPNHMOZDMYNCPO-PDUMRIMRSA-N
Smiles	CCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(=O)CO
Isomeric SMILES	CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)C(=O)CO
PubChem CID	11750009
Molecular Weight	402.52

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
I2221297	Certificate of Analysis	Sep 09, 2022	C413669
I2221298	Certificate of Analysis	Sep 09, 2022	C413669
I2221299	Certificate of Analysis	Sep 09, 2022	C413669
I2221296	Certificate of Analysis	Sep 09, 2022	C413669

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 80 mg/mL (198.74 mM); Ethanol: 80 mg/mL (198.74 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	80
DMSO(mM) Max Solubility	198.747888303687
Water(mg / mL) Max Solubility	＜1
Molecular Weight	402.500 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	402.241 Da
Monoisotopic Mass	402.241 Da
Topological Polar Surface Area	80.700 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	769.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu. (2021) A molecular mechanism investigation of the transdermal/topical absorption classification system on the basis of drug skin permeation and skin retention. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 608 (121082).

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Clascoterone - 99%, high purity , Androgen Receptor antagonist, CAS No.19608-29-8, Androgen Receptor antagonist

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Citations of This Product

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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