Basic Description

Synonyms	86393-32-0 \| Ciloxan \| Ciprofloxacin hydrochloride hydrate \| Ciprofloxacin hydrochloride monohydrate \| Ceprimax \| Oftacilox \| Proquin XR \| Cipropol \| Cipro \| Flociprin \| Proquin \| Ciflox \| Bay o 9867 monohydrate \| Cetraxal \| Bay-o-9867 monohydrate \| Ciprofloxacin HCl monohydrate \| Cipro
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Fluoroquinolone antibiotic. Bacteriostatic agent. Interferes with DNA gyrase causing DNA rewinding stopping DNA and protein synthesis. Active in vivo and in vitro.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Quinoline carboxylic acids

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Quinoline carboxylic acids
Intermediate Tree Nodes	Not available
Direct Parent	Quinoline carboxylic acids
Alternative Parents	N-arylpiperazines Fluoroquinolones Aminoquinolines and derivatives Hydroquinolones Haloquinolines Hydroquinolines Pyridinecarboxylic acids Dialkylarylamines Aryl fluorides Benzenoids Vinylogous amides Heteroaromatic compounds Amino acids Azacyclic compounds Carboxylic acids Dialkylamines Monocarboxylic acids and derivatives Organooxygen compounds Organic oxides Organofluorides Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoline-3-carboxylic acid - Fluoroquinolone - N-arylpiperazine - Aminoquinoline - Haloquinoline - Dihydroquinolone - Dihydroquinoline - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Benzenoid - Aryl fluoride - Aryl halide - Pyridine - 1,4-diazinane - Piperazine - Heteroaromatic compound - Vinylogous amide - Tertiary amine - Amino acid - Amino acid or derivatives - Azacycle - Secondary amine - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Organopnictogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Hydrochloride - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
External Descriptors	hydrate
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrate;hydrochloride
INCHI	InChI=1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2
InChIKey	ARPUHYJMCVWYCZ-UHFFFAOYSA-N
Smiles	C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.O.Cl
Isomeric SMILES	C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.O.Cl
WGK Germany	3
Molecular Weight	367.81(as Anhydrous)
Reaxy-Rn	13474821
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13474821&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	385.800 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	385.12 Da
Monoisotopic Mass	385.12 Da
Topological Polar Surface Area	73.900 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	571.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jian Zhang, Jia-Fang Xie, Jia-Cheng E. Yang, Ding Li, Lu-Bin Zhong, Yu-Ming Zheng. (2023) Ultra-fast degradation of ciprofloxacin by the peroxymonosulfate activation using a Co/Al-LDH decorated magnetic hydrochar: Structural design, catalytic performance and synergistic effects. CHEMICAL ENGINEERING JOURNAL, 477 (146961).
2. Jie Meng, Peng Zhang, Qingjie Liu, Pan Ran, Shuang Xie, Junwu Wei, Xiaohong Li. (2023) Pyroelectric Janus nanomotors for synergistic electrodynamic-photothermal-antibiotic therapies of bacterial infections. Acta Biomaterialia, 162 (20).
3. Zhe Zhao, Yufei Zhang, Yijie Cheng, Jie Li, Wenbo Wang, Siyuan Huang, Xinlong Ma, Xinge Zhang. (2023) Thermosensitive Nanotherapeutics for Localized Photothermal Ablation of MRSA-Infected Osteomyelitis Combined with Chemotherapy. ACS Applied Materials & Interfaces, 15 (10): (12842–12854).
4. Yuan Kaisong, Huang Rui, Gong Kaishuo, Xiao Ziyi, Chen Jialin, Cai Siyao, Shen Jiayi, Xiong Zuer, Lin Zhexuan. (2023) Smartphone-based hand-held polarized light microscope for on-site pharmaceutical crystallinity characterization. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4401-4410).
5. Weijie Hua, Yong Kang, Shuai Liu. (2022) Synergistic removal of aqueous ciprofloxacin hydrochloride by water surface plasma coupled with peroxymonosulfate activation. SEPARATION AND PURIFICATION TECHNOLOGY, 303 (122301).
6. Pei Fan, Chunhua Liu, Zhen Ke, Wei Zhou, Zhonghua Wu. (2022) Growth and physiological responses in a submerged clonal aquatic plant and multiple-endpoint assessment under prolonged exposure to ciprofloxacin. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 239 (113690).
7. J. Lu, Y.-Y. Qin, Y.-L. Wu, Z. Zhu, M.-N. Chen, Y.-S. Yan, C.-X. Li. (2022) Bio-synthesis of molecularly imprinted membrane with photo-regeneration availability for selective separation applications. Materials Today Chemistry, 24 (100836).
8. Yi Hu, Nuzahat Habibul, Yan-Yun Hu, Fan-Li Meng, Guo-Ping Sheng. (2021) Chemical speciation of ciprofloxacin in aqueous solution regulates its phytotoxicity and uptake by rice (Oryza sativa L.). SCIENCE OF THE TOTAL ENVIRONMENT, 771 (144787).
9. Mihebai Yilimulati, Longfei Wang, Xiaoli Ma, Chuanwang Yang, Nuzahat Habibul. (2021) Adsorption of ciprofloxacin to functionalized nano-sized polystyrene plastic: Kinetics, thermochemistry and toxicity. SCIENCE OF THE TOTAL ENVIRONMENT, 750 (142370).
10. Jing Liu, Bin Wang, Huachuan Huang, Dan Jian, Yunan Lu, Yanke Shan, Shouyu Wang, Fei Liu. (2021) Quantitative ciprofloxacin on-site rapid detections using quantum dot microsphere based immunochromatographic test strips. FOOD CHEMISTRY, 335 (127596).
11. Ling Cao, Zheng Li, Rui Jia, Li Chen, Ying Wu, Junwei Di. (2020) Sensitive Photoelectrochemical Determination of Ciprofloxacin Using an Indium Tin Oxide Photoelectrode Modified with Small Gold Nanoparticles. ANALYTICAL LETTERS,
12. Minghao Sun, Chune Zhu, Jieyu Long, Chao Lu, Xin Pan, Chuanbin Wu. (2020) PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections. DRUG DELIVERY, 27 (1): (632-641).
13. Lan-jia Pan, Jie Li, Chun-xing Li, Xiao-da Tang, Guang-wei Yu, Yin Wang. (2018) Study of ciprofloxacin biodegradation by a Thermus sp. isolated from pharmaceutical sludge. JOURNAL OF HAZARDOUS MATERIALS, 343 (59).
14. Pei Fan, Haihao Yu, Tian Lv, Huiyuan Wang, Dexiang Li, Chao Tong, Zhonghua Wu, Dan Yu, Chunhua Liu. (2024) Alien emergent aquatic plants develop better ciprofloxacin tolerance and metabolic capacity than one native submerged species. SCIENCE OF THE TOTAL ENVIRONMENT, 932 (173030).
15. Yi Hu, Fan-Li Meng, Jia-Heng Zhao, Guo-Ping Sheng. (2024) Environmental microbes alleviate antibiotic disturbance on plant endophytes in aquatic microcosms: Prospects for conferring fitness benefits. WATER RESEARCH, 262 (122112).
16. Luzhan Huang, Yongchao Jiang, Pengcheng Zhang, Muhan Li, Bingrong Liu, Keyong Tang. (2024) Injectable Modified Sodium Alginate Microspheres for Enhanced Operative Efficiency and Safety in Endoscopic Submucosal Dissection. BIOMACROMOLECULES, 25 (5): (2953-2964).
17. Shilin Li, Yunhui Tian, Guangxin Zhang. (2024) Modulating of Bi2MoO6-based photocatalyst through manipulation of reactant ratios for enhanced visible light photocatalytic activity. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 692 (133958).
18. Muhammad Noman, Guangwei Yu, Dinkayehu Tsegaye Awugichew, Xinlin Li. (2024) Synthesis of surficial-modified green biochar catalyst generated by biogas residue biochar and potential application for catalytic ozonation degradation of ciprofloxacin. ENVIRONMENTAL RESEARCH, 257 (119314).

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

=

Concentration

x

Volume

x

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

x

Volume 1 (V1)

=

Concentration 2 (C2)

x

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

=

Mass (in vial)

÷

Desired Reconstitution Concentration

Ciprofloxacin Hydrochloride Monohydrate - 10mM in DMSO, high purity , CAS No.86393-32-0