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Ciprofloxacin hydrochloride - ≥97%, high purity , Topoisomerase IV, CAS No.86483-48-9, Topoisomerase IV

    Grade & Purity:
  • ≥97%
In stock
Item Number
C304792
Grouped product items
SKU Size
Availability
Price Qty
C304792-25g
25g
2
$10.90
C304792-100g
100g
2
$20.90
C304792-500g
500g
1
$58.90

Basic Description

Synonyms Ciprofloxacin hydrochloride | 93107-08-5 | Ciprofloxacin HCl | 86483-48-9 | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride | Cipro | Ciprofloxacin Hydrochloride Anhydrous | CHEBI:310388 | 0MP32MFP6C | 1-cyclopropyl-6-fl
Specifications & Purity ≥97%
Storage Temp Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action Topoisomerase IV

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Quinolines and derivatives
Subclass Quinoline carboxylic acids
Intermediate Tree Nodes Not available
Direct Parent Quinoline carboxylic acids
Alternative Parents N-arylpiperazines  Fluoroquinolones  Aminoquinolines and derivatives  Hydroquinolones  Haloquinolines  Hydroquinolines  Pyridinecarboxylic acids  Dialkylarylamines  Aryl fluorides  Benzenoids  Vinylogous amides  Heteroaromatic compounds  Amino acids  Azacyclic compounds  Carboxylic acids  Dialkylamines  Monocarboxylic acids and derivatives  Organooxygen compounds  Organic oxides  Organofluorides  Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinoline-3-carboxylic acid - Fluoroquinolone - N-arylpiperazine - Aminoquinoline - Haloquinoline - Dihydroquinolone - Dihydroquinoline - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Benzenoid - Aryl fluoride - Aryl halide - Pyridine - 1,4-diazinane - Piperazine - Heteroaromatic compound - Vinylogous amide - Tertiary amine - Amino acid - Amino acid or derivatives - Azacycle - Secondary amine - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Organopnictogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Hydrochloride - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
External Descriptors hydrochloride

Associated Targets(Human)

TOP2B Tclin DNA topoisomerase II beta (959 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus pneumoniae (31063 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fusarium solani (1274 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella oxytoca (929 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecium (13803 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aspergillus flavus (8875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Listeria monocytogenes (2626 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Penicillium chrysogenum (1593 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella enterica (1497 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L6 (7924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus anthracis (2936 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Stachybotrys chartarum (30 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504753900
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504753900
IUPAC Name 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
INCHI InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
InChIKey DIOIOSKKIYDRIQ-UHFFFAOYSA-N
Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
Isomeric SMILES C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
Alternate CAS 93107-08-5
Molecular Weight 367.8
Reaxy-Rn 4627629
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4627629&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
J2308432 Certificate of Analysis Oct 10, 2023 C304792
J2308436 Certificate of Analysis Oct 10, 2023 C304792
J2308433 Certificate of Analysis Oct 10, 2023 C304792
D2526058 Certificate of Analysis Oct 10, 2023 C304792
E2407066 Certificate of Analysis Oct 10, 2023 C304792
I2429030 Certificate of Analysis Oct 10, 2023 C304792
J2308434 Certificate of Analysis Oct 10, 2023 C304792
J2308435 Certificate of Analysis Oct 10, 2023 C304792

Chemical and Physical Properties

Sensitivity light sensitive
Melt Point(°C) >300℃
Molecular Weight 367.800 g/mol
XLogP3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 3
Exact Mass 367.11 Da
Monoisotopic Mass 367.11 Da
Topological Polar Surface Area 72.900 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 571.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

1. Zhang Wenqin, Cai Xiaozhen, Zhang Xinyi, Zou Shiqi, Zhu Danhong, Zhang Qiulong, Chen Jianmin.  (2023)  AgNPs-Modified Polylactic Acid Microneedles: Preparation and In Vivo/In Vitro Antimicrobial Studies.  PHARMACEUTICAL RESEARCH,    (1-12). 
2. Jun Yao.  (2024)  A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2.  ANALYTICA CHIMICA ACTA,  1288  (342141). 
3. Yulong Chen, Yuan Chi, Xiao Wu, Cong Lin, Tengfei Lin, Min Gao, Chunlin Zhao, Baisheng Sa.  (2023)  O-Vacancy-Rich ε-MnO2 Synthesized at Hydrophobic Interface: An Efficient Fenton-like Catalyst for Removing Ciprofloxacin from Water.  Crystals,  13  (12): (1664). 
4. Xiaojing Qin, Weibo Meng, Song Cheng, Baolin Xing, Changliang Shi, Yanhe Nie, Qiang Wang, Hongying Xia.  (2023)  Efficient removal of heavy metal and antibiotics from wastewater by phosphate-modified hydrochar.  CHEMOSPHERE,  345  (140484). 
5. Xu Liu, Xiao Han, Yushuang Shang, Lijuan Wang, Jian Shen, Jiang Yuan.  (2023)  Hydrogen sulfide releasing poly(γ-glutamic acid) biocomposite hydrogel with monitoring, antioxidant, and antibacterial properties for diabetic wound healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (127053). 
6. Qing Zhang, Lin Zhang, Yuhan Zhang, Yi Wang, Rong Ju, Guoqing Wei.  (2023)  Repolarization of Inflammation-Associated Macrophages by Dual Drug-Loaded Liposomes for Acute Lung Sepsis Antibacterial and Anti-inflammatory Therapy.  ACS Applied Nano Materials,  (17): (15829–15840). 
7. Haiping Wang, Xueren Qian, Xianhui An.  (2023)  Visual fluorescence detection of ciprofloxacin by Zn-metal-organic framework@nanocellulose transparent films based on aggregation-induced emission.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  251  (126363). 
8. Yuanqian Xiong, Dong Zhang, Cuizhu Ye, Yu Wang, Xiangrui Deng, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Qianhui Gu, Ganhui Huang.  (2023)  Ultra-sensitive detection of ciprofloxacin hydrochloride in milk by molecularly imprinted electrochemical sensor based on S-CoFe-MOFs/AuNPs.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  122  (105439). 
9. Huifang Wu, Shiying Ju, Yuwei Ling, Haozhe Sun, Yanfeng Tang, Changlun Tong.  (2023)  Gelatinous lanthanide coordination polymer with aggregation-enhanced antenna effect for ratiometric detection of endogenous alkaline phosphatase.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  645  (338). 
10. Wangjing Zhai, Wenqi Jiang, Qiqi Guo, Zhixuan Wang, Donghui Liu, Zhiqiang Zhou, Peng Wang.  (2023)  Existence of antibiotic pollutant in agricultural soil: Exploring the correlation between microbiome and pea yield.  SCIENCE OF THE TOTAL ENVIRONMENT,  871  (162152). 
11. Dan Li, Danyang Wang, Ye He, Bailong Tao, Xiaoxia Liu, Yulu Yang, Lu Tan, Yuchen Zhang, Jingwei Hu, Weihu Yang, Yu Tang, Kaiyong Cai.  (2023)  A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,  143  (93). 
12. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo.  (2023)  Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces.  Matter,  (260-273). 
13. Tongyao Lin, Jinglin Zhang, Hui Long, Fengjuan Yang, Langhuan Huang, Sui-Ping Deng, Jingxian Zhang, Xiang Cai, Yunhua Yang, Shaozao Tan.  (2022)  Temperature-Sensitive Hydrogels Containing Carboxylated Chitosan-Modified Carbon Nanotubes for Controlled Drug Release.  ACS Applied Nano Materials,  (8): (10409–10420). 
14. Xu Junge, Hu Die, Wang Yingmu, Zhang Ziwei.  (2022)  α-(Fe, Cu)OOH/RGO nanocomposites for heterogeneous photo-Fenton-like degradation of ciprofloxacin under visible light irradiation.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  29  (52): (78874-78886). 
15. Yongwu He, Songling Han, Gaomei Zhao, Jiaohua Luo, Changsheng Jia, Yin Chen, Qi Liu, Jining Gao, Cheng Wang, Junping Wang.  (2022)  Zinc oxide-coated carboxyl-riched graphene oxide efficiently degrades microcystin-leucine arginine and antibiotics under visible light.  Journal of Environmental Chemical Engineering,  10  (107829). 
16. Chang Ping Yang, Cong Yi Hu, Zhong Wei Jiang, Si Yu Xiao, Xiao Yan Wang, Cheng Zhi Huang, Yuan Fang Li, Shu Jun Zhen.  (2022)  Facile synthesis of porphyrin-MOFs with high photo-Fenton activity to efficiently degrade ciprofloxacin.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  622  (690). 
17. Yafang Shen, Fei Jia, Aoming Liang, Yawen He, Yaping Peng, Huang Dai, Yingchun Fu, Jianping Wang, Yanbin Li.  (2022)  Monovalent Antigen-Induced Aggregation (MAA) Biosensors Using Immunomagnetic Beads in Both Sample Separation and Signal Generation for Label-Free Detection of Enrofloxacin.  ACS Applied Materials & Interfaces,  14  (7): (8816–8823). 
18. Cuizhu Ye, Xingguang Chen, Dong Zhang, Junjun Xu, Huiting Xi, Tiantian Wu, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Ganhui Huang.  (2021)  Study on the properties and reaction mechanism of polypyrrole@norfloxacin molecularly imprinted electrochemical sensor based on three-dimensional CoFe-MOFs/AuNPs.  ELECTROCHIMICA ACTA,  379  (138174). 
19. Jian Lu, Ying-Ying Qin, Yi-Lin Wu, Mu-Ning Chen, Chang Sun, Zi-Xuan Han, Yong-Sheng Yan, Chun-Xiang Li, Yan Yan.  (2021)  Mimetic-core-shell design on molecularly imprinted membranes providing an antifouling and high-selective surface.  CHEMICAL ENGINEERING JOURNAL,  417  (128085). 
20. Haijin Liu, Hui Zhang, Min Chen, Chaonan Zhang, Cuiwei Du, Jianbiao Peng, Kai Jiang.  (2020)  Peroxymonosulfate-assisted photocatalysis with g-C3N4/BiOCOOH nanocomposites for the synergistic removal of organic pollutants.  Journal of Water Process Engineering,  38  (101580). 
21. Mingdian Zhou, Chunxing Li, Lixin Zhao, Jing Ning, Xiaofang Pan, Guanjing Cai, Gefu Zhu.  (2021)  Synergetic effect of nano zero-valent iron and activated carbon on high-level ciprofloxacin removal in hydrolysis-acidogenesis of anaerobic digestion.  SCIENCE OF THE TOTAL ENVIRONMENT,  752  (142261). 
22. Min Liu, Lei Wang, Xiaowen Tong, Jiamu Dai, Guang Li, Peihua Zhang, Huaifang Li.  (2020)  Antibacterial polymer nanofiber-coated and high elastin protein-expressing BMSCs incorporated polypropylene mesh for accelerating healing of female pelvic floor dysfunction.  Nanotechnology Reviews,  (1): (670-682). 
23. Sun Lijian, Yang Shuaishuai, Qian Xueren, An Xianhui.  (2020)  Cyclodextrin and cellulose combination product developed by click chemistry: fascinating design for inclusion of ciprofloxacin.  CELLULOSE,  27  (10): (5955-5970). 
24. Binyu He, Huawen Peng, Yang Chen, Qiang Zhao.  (2020)  High performance polyamide nanofiltration membranes enabled by surface modification of imidazolium ionic liquid.  JOURNAL OF MEMBRANE SCIENCE,  608  (118202). 
25. Yuqi Huang, Yue Wang, Yuzhou Huang, Lixuan Zhang, Fan Ye, Jinling Wang, Jingge Shang, Qianjiahua Liao.  (2020)  Impact of sediment characteristics on adsorption behavior of typical antibiotics in Lake Taihu, China.  SCIENCE OF THE TOTAL ENVIRONMENT,  718  (137329). 
26. Jiaxing Huang, Daguang Li, Ruobai Li, Qianxin Zhang, Tiansheng Chen, Haijin Liu, Yang Liu, Wenying Lv, Guoguang Liu.  (2019)  An efficient metal-free phosphorus and oxygen co-doped g-C3N4 photocatalyst with enhanced visible light photocatalytic activity for the degradation of fluoroquinolone antibiotics.  CHEMICAL ENGINEERING JOURNAL,  374  (242). 
27. Miao Xiao, Han Lu, Wang Lei, Wang Min, Sun XiaoHui, Zhu XiaoTao, Ge Bo.  (2019)  Preparation of PDVB/TiO2 composites and the study on the oil-water separation and degradation performances.  Science China-Technological Sciences,  62  (7): (1217-1223). 
28. Sun Lijian, Ding Chunyue, Qian Xueren, An Xianhui.  (2019)  Effective and simple one-step strategy for preparation of “clickable” cellulose modules: support to build antibacterial materials.  CELLULOSE,  26  (3): (1961-1976). 
29. Lijian Sun, Guifa Xiao, Xueren Qian, Xianhui An.  (2019)  Alkyne functionalized cellulose fibers: A versatile “clickable” platform for antibacterial materials.  CARBOHYDRATE POLYMERS,  207  (68). 
30. Kiran Gupta, Jiang-Bo Huo, Jia-Cheng E. Yang, Ming-Lai Fu, Baoling Yuan, Zhangxu Chen.  (2019)  (MoS4)2− intercalated CAMoS4⋅LDH material for the efficient and facile sequestration of antibiotics from aqueous solution.  CHEMICAL ENGINEERING JOURNAL,  355  (637). 
31. Jie Ni, Jinjuan Xue, Jing Shen, Guangyu He, Haiqun Chen.  (2018)  Fabrication of ZnAl mixed metal-oxides/RGO nanohybrid composites with enhanced photocatalytic activity under visible light.  APPLIED SURFACE SCIENCE,  441  (599). 
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33. Zhi-Chao Xiong, Zi-Yue Yang, Ying-Jie Zhu, Fei-Fei Chen, Yong-Gang Zhang, Ri-Long Yang.  (2017)  Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit.  ACS Applied Materials & Interfaces,  (27): (22212–22222). 
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36. Fei Wang, Baoshan Yang, Hui Wang, Qixuan Song, Fengjiao Tan, Yanan Cao.  (2016)  Removal of ciprofloxacin from aqueous solution by a magnetic chitosan grafted graphene oxide composite.  JOURNAL OF MOLECULAR LIQUIDS,  222  (188). 
37. Yuanyuan Sun, Hong Li, Guangci Li, Baoyu Gao, Qinyan Yue, Xuebing Li.  (2016)  Characterization and ciprofloxacin adsorption properties of activated carbons prepared from biomass wastes by H3PO4 activation.  BIORESOURCE TECHNOLOGY,  217  (239). 
38. Jian-Rong Li, Yun-Xia Wang, Xu Wang, Baoling Yuan, Ming-Lai Fu.  (2015)  Intercalation and adsorption of ciprofloxacin by layered chalcogenides and kinetics study.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  453  (69). 
39. Jintai Lin, Xuan Xu, Wohua Zhou, Liudan Yu, Qianming Wang.  (2015)  Easy assembly of visible light excited lanthanide containing edifices and structural origin.  DYES AND PIGMENTS,  119  (56). 
40. Tiefan Huang, Lin Zhang, Huanlin Chen, Congjie Gao.  (2015)  A cross-linking graphene oxide–polyethyleneimine hybrid film containing ciprofloxacin: one-step preparation, controlled drug release and antibacterial performance.  Journal of Materials Chemistry B,  (8): (1605-1611). 
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