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Cinaciguat - ≥98%, high purity , Soluble guanylate cyclase activator, CAS No.329773-35-5, Soluble guanylate cyclase activator

COA COA
In stock
Item Number
C125941
Grouped product items
SKU Size
Availability
 Price Qty
C125941-1mg
1mg
2
$59.90
C125941-5mg
5mg
1
$139.90
C125941-10mg
10mg
1
$239.90
C125941-25mg
25mg
1
$399.90
C125941-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$589.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
G Protein Related (287) GPCR/G Protein (3172) Guanylate Cyclase (31) Guanylyl cyclase，α1β1 Activator (9) Guanylyl cyclase，α2β1 Activator (5)

Basic Description

Synonyms HY-14181 | Cinaciguat (BAY 58-2667) | Cinaciguat [INN:JAN] | 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoicacid | Cinaciguat (JAN/INN) | cinaciguatum | Z90 | D07577 | GEQBPMNDDHGGPJ-UHFFFAOYSA-N | NSC-98326 | 4-[[4-carboxybu
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms

Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure. Cinaciguat has potent preload- and afterload-reducing effects, increasing ca

Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type ACTIVATOR
Mechanism of action Soluble guanylate cyclase activator
Product Description

Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Stilbenes
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Stilbenes
Alternative Parents Benzoic acids  Phenethylamines  Benzoyl derivatives  Benzylamines  Phenylmethylamines  Phenol ethers  Phenoxy compounds  Aralkylamines  Alkyl aryl ethers  Amino acids  Trialkylamines  Carboxylic acids  Monocarboxylic acids and derivatives  Hydrocarbon derivatives  Carbonyl compounds  Organic oxides  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Stilbene - Benzoic acid or derivatives - Benzoic acid - Phenethylamine - Phenoxy compound - Benzoyl - Benzylamine - Phenol ether - Phenylmethylamine - Alkyl aryl ether - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Tertiary amine - Tertiary aliphatic amine - Amino acid or derivatives - Amino acid - Monocarboxylic acid or derivatives - Ether - Carboxylic acid - Carboxylic acid derivative - Amine - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors Not available

Product Properties

ALogP 4.9

Associated Targets(Human)

GUCY1A1 Tclin Guanylate cyclase soluble subunit alpha-1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GUCY1A2 Tclin Guanylate cyclase soluble subunit alpha-2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GUCY1B1 Tclin Guanylate cyclase soluble subunit beta-1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GUCY1B1 Tclin Soluble guanylate cyclase alpha1/beta1 complex (109 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-[[4-carboxybutyl-[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid
INCHI InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41)
InChIKey WPYWMXNXEZFMAK-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)CCC2=CC=C(C=C2)COC3=CC=CC=C3CCN(CCCCC(=O)O)CC4=CC=C(C=C4)C(=O)O
Isomeric SMILES C1=CC=C(C=C1)CCC2=CC=C(C=C2)COC3=CC=CC=C3CCN(CCCCC(=O)O)CC4=CC=C(C=C4)C(=O)O
Molecular Weight 565.70
Reaxy-Rn 9676935
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9676935&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number Certificate Type Date Item
C2425184 Certificate of Analysis Feb 27, 2024 C125941
C2425185 Certificate of Analysis Feb 27, 2024 C125941
C2425186 Certificate of Analysis Feb 27, 2024 C125941
C2425187 Certificate of Analysis Feb 27, 2024 C125941
C2425188 Certificate of Analysis Feb 27, 2024 C125941
C2425189 Certificate of Analysis Feb 27, 2024 C125941
C2425190 Certificate of Analysis Feb 27, 2024 C125941
C2425191 Certificate of Analysis Feb 27, 2024 C125941
C2425192 Certificate of Analysis Feb 27, 2024 C125941

Chemical and Physical Properties

Solubility DMSO
Molecular Weight 565.700 g/mol
XLogP3 4.900
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 17
Exact Mass 565.283 Da
Monoisotopic Mass 565.283 Da
Topological Polar Surface Area 87.100 Ų
Heavy Atom Count 42
Formal Charge 0
Complexity 767.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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