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Cimetidine - 10mM in DMSO, high purity , CAS No.51481-61-9(DMSO), Histamine H2 receptor antagonist
H2 receptor Selective Agonists | Antagonists
Basic Description
| Synonyms |
SKF-92334 | 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine |
| Specifications & Purity |
Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms |
Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors. |
| Storage Temp |
Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade |
Moligand™ |
| Action Type |
ANTAGONIST, INHIBITOR |
| Mechanism of action |
Histamine H2 receptor antagonist |
| Product Description |
Information Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.
In vitro
In vivo
Cell Data
cell lines：MV4-11 Concentrations： Incubation Time： Powder Purity:≥96%
|
Product Properties
| ALogP |
0.007 |
| hba_count |
2 |
| HBD Count |
3 |
| Rotatable Bond |
7 |
Associated Targets(Human)
Names and Identifiers
| Smiles |
CNC(NCCSCC1=C(C)[NH]C=N1)=NC#N |
| Molecular Weight |
252.34 |
| Reaxy-Rn |
888260 |
| Reaxys-RN_link_address |
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=888260&ln= |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
| Solubility |
Solubility (25°C) In vitro DMSO: 56 mg/mL (201.97 mM); Water: ˂1 mg/mL Ethanol: ˂1 mg/mL |
| DMSO(mg / mL) Max Solubility |
51 |
| DMSO(mM) Max Solubility |
202.11 |
| Water(mg / mL) Max Solubility |
<1 |
Citations of This Product
|
1.
Lu Zhao, Jie Liu, Yunfeng Bai, Feng Feng, Xiaoming Yang.
(2021)
Exploration of carbon dots derived from epimedium towards detecting dopamine and hydrogen peroxide.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,
627
(127179).
|
|
2.
Renjie Xu, Hongdan Zhu, Lingmin Hu, Beimeng Yu, Xiaohua Zhan, Yichu Yuan, Ping Zhou.
(2020)
Characterization of the intestinal absorption of morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 cell monolayer model.
PLoS One,
15
(5):
(e0227844).
|
|
3.
Lisha Jin, Sisi Zhou, Shujie Zhu, Shaowei Lei, Weijuan Du, Huidi Jiang, Su Zeng, Hui Zhou.
(2019)
Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters.
EUROPEAN JOURNAL OF PHARMACOLOGY,
864
(172725).
|
|
4.
Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng.
(2019)
Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
|
|
5.
Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhang.
(2019)
Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells.
Food & Function,
10
(8):
(5215-5227).
|
|
6.
Renjie Xu, Yichu Yuan, Jia Qi, Jia Zhou, Xiaowen Guo, Jian Zhang, Ruanjuan Zhan.
(2018)
Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model.
Evidence-based Complementary and Alternative Medicine,
2018
(8340563).
|
|
7.
Xu Renjie, Peng Ying, Wang Mengyue, Li Xiaobo.
(2019)
Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,
44
(2):
(295-303).
|
|
8.
Li Wang, Yan Sun, Qi Liu.
(2015)
Determination of Pharmaceuticals and Personal Care Product Components in Wastewater Using Capillary Electrophoresis Coupled with Solid Phase Extraction.
ANALYTICAL LETTERS,
|
|
9.
Guodong Shan, Xiuqin Fan, Qingcheng Wang, Li Zhang, Lijun Ge, Weibo Lu, Jing Xue, Kang Chen, Zejun Wang, Qing Shen.
(2025)
Development of a Captiva EMR-lipid clean-up and LC-MS/MS methodology for detecting H2 receptor antagonists in functional foods and food-medicine homology materials.
Applied Food Research,
5
(100772).
|
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9 Citations