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Chlorpheniramine Maleate - ≥99%, high purity , Histamine H1 receptor antagonist, CAS No.113-92-8, Histamine H1 receptor antagonist
Potent H 1 antagonist and SNRI
Basic Description
Synonyms
Allerclor | CHLORPHENAMINE MALEATE (EP MONOGRAPH) | Histaspan-D | Allergy Time | ChlorphenamineMaleate | Ru-Tuss Capsules | V1Q0O9OJ9Z | Chlor-trimeton 12 hour | Histaspan-Plus | Pyridamal | 1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-alpha-pyridyl)propane
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engageme
Shipped In
Normal
Action Type
ANTAGONIST
Mechanism of action
Histamine H1 receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Pyridines and derivatives
Subclass
Pheniramines
Intermediate Tree Nodes
Not available
Direct Parent
Pheniramines
Alternative Parents
Chlorobenzenes Aralkylamines Unsaturated fatty acids Dicarboxylic acids and derivatives Aryl chlorides Heteroaromatic compounds Trialkylamines Carboxylic acids Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework
Not available
Substituents
Pheniramine - Chlorobenzene - Halobenzene - Aralkylamine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Unsaturated fatty acid - Benzenoid - Fatty acid - Fatty acyl - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Azacycle - Carboxylic acid - Carboxylic acid derivative - Hydrocarbon derivative - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Carbonyl group - Organic oxide - Organochloride - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as pheniramines. These are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton.
External Descriptors
organic molecular entity
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
Pubchem Sid
488195226
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/488195226
IUPAC Name
(Z)-but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
INCHI
InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
Smiles
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
Isomeric SMILES
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
WGK Germany
3
RTECS
US6504000
Molecular Weight
390.86
Reaxy-Rn
32218648
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32218648&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Solubility
Solubility: Soluble in water
Sensitivity
Light sensitive
Melt Point(°C)
130-135℃
Molecular Weight
390.900 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
7
Exact Mass
390.135 Da
Monoisotopic Mass
390.135 Da
Topological Polar Surface Area
90.700 Ų
Heavy Atom Count
27
Formal Charge
0
Complexity
368.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
1
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
1
Covalently-Bonded Unit Count
2
Citations of This Product
1.
Xiaohong Zhang, Junfan Niu, Zhiyuan Zhou, Gang Tang, Guangyao Yan, Yulu Liu, Jialu Wang, Gaohua Hu, Jianhua Xiao, Weiyao Yan, Yongsong Cao.
(2023)
Stimuli-responsive polymeric micelles based on cellulose derivative containing imine groups with improved bioavailability and reduced aquatic toxicity of pyraclostrobin. CHEMICAL ENGINEERING JOURNAL,
474
(145789).
2.
Ruike Song, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang.
(2023)
Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations. JOURNAL OF SEPARATION SCIENCE,
46
(8):
(2201039).
3.
Haibo You, Ben Chen, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong.
(2022)
Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl-β-cyclodextrin as mobile phase additive. CHIRALITY,
35
(1):
(58-66).
4.
Qi Tang, Long-Xiang He, Xiao-Kun Chu, Bing Yu, Xiang-Ling Gu, You-Qing Shen, Hai-Lin Cong.
(2021)
Synthesis and enantioseparation characteristics of a novel β-cyclodextrin chiral stationary phase based on diazotized silica in HPLC. FERROELECTRICS,
5.
Xuefeng Li, Chunchen Zhang, Shuting Wu, Xing Chen, John Mai, Ming-Wei Chang.
(2019)
Precision Printing of Customized Cylindrical Capsules with Multifunctional Layers for Oral Drug Delivery. ACS Applied Materials & Interfaces,
11
(42):
(39179–39191).
6.
Qi Tang, Bing Yu, Lilong Gao, Hailin Cong, Shuai Zhang.
(2018)
Light-assisted preparation of a cyclodextrin-based chiral stationary phase and its separation performance in liquid chromatography. NEW JOURNAL OF CHEMISTRY,
42
(2):
(1115-1120).
7.
Zhen Zhang, Yue Wang, Shuai Lv, Hailin Cong, Youqing Shen, Bing Yu.
(2024)
Isocyanate-chitin modified microspheres for chiral drug separation in high performance liquid chromatography. JOURNAL OF APPLIED POLYMER SCIENCE,
141
(27):
(e55594).
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7 Citations
B2314176