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Chemerin-9 (149-157) TFA, Agonist of chemerin receptor 1;Agonist of chemerin receptor 2, CAS No.676367-27-4(free base), Agonist of chemerin receptor 1;Agonist of chemerin receptor 2

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Item Number
C287731
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C287731-1mg
1mg
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$46.90
C287731-5mg
5mg
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$146.90
C287731-10mg
10mg
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$234.90
C287731-25mg
25mg
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$469.90
C287731-50mg
50mg
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$749.90
C287731-100mg
100mg
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$1,199.90

Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin

Basic Description

Product Name Chemerin-9 (149-157) TFA, Agonist of chemerin receptor 1;Agonist of chemerin receptor 2, CAS No.676367-27-4(free base)
Synonyms Chemerin-9, Human TFA
Grade Moligand™
Product Description

Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.

Specifications & Purity Moligand™, ≥95%
Biochemical and Physiological Mechanisms Potent chemokine-like receptor 1 (CMKLR1; also known as chemerin receptor 23, ChemR23) agonist (EC50= 7.1 nM at CMKLR expressed in CHO cells). Corresponds to C-terminal of full length human Chemerin, amino acids 149 - 157. Activates Gi/osignaling pathways
Sequence YFPGQFAFS
Action Type AGONIST
Mechanism of action Agonist of chemerin receptor 1;Agonist of chemerin receptor 2

Associated Targets(Human)

GPR1 Tchem G-protein coupled receptor 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CMKLR1 Tchem Chemokine-like receptor 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

Storage Temp Store at -20°C
Shipped In Ice chest + Ice pads
CAS 676367-27-4(free base)

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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10 results found

Lot Number Certificate Type Date Item
F2510579 Certificate of Analysis Nov 29, 2024 C287731
F2510581 Certificate of Analysis Nov 29, 2024 C287731
F2510582 Certificate of Analysis Nov 29, 2024 C287731
F2510583 Certificate of Analysis Nov 29, 2024 C287731
F2510585 Certificate of Analysis Nov 29, 2024 C287731
F2510577 Certificate of Analysis Nov 29, 2024 C287731
F2510578 Certificate of Analysis Nov 29, 2024 C287731
F2510580 Certificate of Analysis Nov 29, 2024 C287731
F2510584 Certificate of Analysis Nov 29, 2024 C287731
F2510586 Certificate of Analysis Nov 29, 2024 C287731

Genetic information

Alternate Names Chemerin-9, Human TFA
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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