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Protein Tyrosine Kinase/RTK
c-Fms
cFMS Receptor Inhibitor IV - ≥98%, high purity , CAS No.959626-45-0

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cFMS Receptor Inhibitor IV - ≥98%, high purity , CAS No.959626-45-0

COA

Grade & Purity:

≥98%

Cas Number: 959626-45-0
Molecular Weight: 378.47
PubChem CID: 28408236
PubChem SID: 504770089

In stock

Item Number

C333550

Grouped product items
SKU	Size	Availability	Price
C333550-5mg	5mg	3	$246.90
C333550-25mg	25mg	3	$741.90
C333550-100mg	100mg	2	$1,781.90
C333550-250mg	250mg	3	$4,009.90

a cell-permeable furan carboxamide compound

View related series

c-Fms (43) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	MS-26181 \| cFMS Receptor Inhibitor IV \| EC-000.2370 \| 5-Cyano-N-(2,5-di-1-piperidinylphenyl)-2-furancarboxamide \| SCHEMBL16050404 \| 5-cyano-N-[2,5-di(piperidin-1-yl)phenyl]furan-2-carboxamide \| EX-A6581 \| 5-cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-ca
Specifications & Purity	≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	cFMS Receptor Inhibitor IV is a cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive c-Fms-CSF-1R (cFMS/CSF-1R) inhibitor. cFMS Receptor Inhibitor IV blocks cFMS autophosphorylation in cell-free\|in vitro\|kinase assays and in CSF-1/M-CSF-stimulated HEK-293 cells. A cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive cFMS/CSF-1R inhibitor that blocks cFMS autophosphorylation both in CSF-1/M-CSF-stimulated HEK-293 cells (IC50 = 76 nM) and in cell-free in vitro kinase assays (IC50 = 17 nM).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides
      - Level5 Aromatic anilides
        Level6 Furanilides
        Level7 2-furanilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Aromatic anilides - Furanilides
Direct Parent	2-furanilides
Alternative Parents	Phenylpiperidines Furoic acid and derivatives Dialkylarylamines Aniline and substituted anilines 2-heteroaryl carboxamides Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Oxacyclic compounds Nitriles Azacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-furanilide - Phenylpiperidine - 2-heteroaryl carboxamide - Furoic acid or derivatives - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - Piperidine - Furan - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Tertiary amine - Carboxylic acid derivative - Carbonitrile - Nitrile - Oxacycle - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Amine - Cyanide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 2-furanilides. These are aromatic heterocyclic compounds contaning a furan ring that is substituted at the 2-position with an anilide.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

pKa	pKₐ: 10.55 (Predicted), pKₐ: 8.02 (Predicted)

Associated Targets(Human)

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor (1 Activities)

Discover Target: CSF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770089
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770089
IUPAC Name	5-cyano-N-[2,5-di(piperidin-1-yl)phenyl]furan-2-carboxamide
INCHI	InChI=1S/C22H26N4O2/c23-16-18-8-10-21(28-18)22(27)24-19-15-17(25-11-3-1-4-12-25)7-9-20(19)26-13-5-2-6-14-26/h7-10,15H,1-6,11-14H2,(H,24,27)
InChIKey	FQGXFVDABCBEFW-UHFFFAOYSA-N
Smiles	C1CCN(CC1)C2=CC(=C(C=C2)N3CCCCC3)NC(=O)C4=CC=C(O4)C#N
Isomeric SMILES	C1CCN(CC1)C2=CC(=C(C=C2)N3CCCCC3)NC(=O)C4=CC=C(O4)C#N
Molecular Weight	378.47
Reaxy-Rn	11267166
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11267166&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
I2220230	Certificate of Analysis	Jul 10, 2025	C333550
I2220231	Certificate of Analysis	Jul 10, 2025	C333550
I2220232	Certificate of Analysis	Jul 10, 2025	C333550
I2220243	Certificate of Analysis	Jul 10, 2025	C333550

Chemical and Physical Properties

Solubility	Soluble in DMSO (5 mg/ml).
Sensitivity	Light sensitive
Refractive Index	n20D1.63 (Predicted)
Boil Point(°C)	530.49° C at 760 mmHg (Predicted)
Molecular Weight	378.500 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	378.206 Da
Monoisotopic Mass	378.206 Da
Topological Polar Surface Area	72.500 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	576.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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