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CDK5 inhibitor 20-223 - 99%, high purity , CAS No.865317-30-2

COA

Grade & Purity:

≥99%

Cas Number: 865317-30-2
Molecular Weight: 305.37
PubChem CID: 69761759

In stock

Item Number

C647987

Grouped product items
SKU	Size	Availability	Price
C647987-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$200.90
C647987-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
C647987-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$650.90
C647987-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90

View related series

CDK (252) Cell Cycle (2830) Cell Cycle/DNA Damage (2602)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC 50 s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC 50 s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent In Vitro CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines. ?\nCDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells Concentration: 10 μM, 1 μM, 100 nM, 10 nM Incubation Time: 72 hours Result: Reduced cell growth. IC50s of 168±20, 480±41, 360±72, 763±92, 117±49, 568±49, 79±31 nM for SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells. Western Blot AnalysisCell Line: CRC cell lines GEO, HCT116 and HT29 Concentration: 20, 10, 5, 2.5, 1.25, 0.625, 0.3125 μM Incubation Time: 6 hours Result: Did not affect the total levels of CDK2/5, and the levels of total FAK or total Retinoblastoma protein (Rb). Induced a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels. In Vivo CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Athymic nude mice Dosage: 8 mg/kg Administration: Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections. Result: Reduced tumor growth and tumor weight in vivo. Form:Solid IC50& Target:CDK2 6.0 nM (IC 50 ) CDK5 8.8 nM (IC 50 )

Associated Targets(Human)

BXPC-3 (2997 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MIA PaCa-2 (5949 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ASPC1 (1310 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK5 Tchem Cyclin-dependent kinase 5/CDK5 activator 1 (3697 Activities)

Discover Target: CDK5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-naphthalen-2-ylacetamide
INCHI	InChI=1S/C19H19N3O/c23-19(20-18-12-17(21-22-18)15-6-3-7-15)11-13-8-9-14-4-1-2-5-16(14)10-13/h1-2,4-5,8-10,12,15H,3,6-7,11H2,(H2,20,21,22,23)
InChIKey	AGVIDDQHAQSPIZ-UHFFFAOYSA-N
Smiles	C1CC(C1)C2=CC(=NN2)NC(=O)CC3=CC4=CC=CC=C4C=C3
Isomeric SMILES	C1CC(C1)C2=CC(=NN2)NC(=O)CC3=CC4=CC=CC=C4C=C3
PubChem CID	69761759
Molecular Weight	305.37

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CDK5 inhibitor 20-223 - 99%, high purity , CAS No.865317-30-2

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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