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CDK2-IN-73 (CDK2-IN-4) - 98%, high purity , CAS No.2079895-42-2

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
C412291
Grouped product items
SKU Size
Availability
 Price Qty
C412291-5mg
5mg
1
$216.90
C412291-10mg
10mg
1
$353.90
C412291-25mg
25mg
1
$599.90
C412291-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$849.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

CDK2 Selective Inhibitors

View related series
CDK (252) CDK inhibitor (2) Cell Cycle (2830) Cell Cycle/DNA Damage (2602)

Basic Description

Synonyms CDK2 inhibitor 73Benzenesulfonamide,4-​[(6-​[1,​1'-​biphenyl]​-​3-​yl-​9H-​purin-​2-​yl)​amino]​-
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms CDK2-IN-73 (CDK2-IN-4, CDK2 inhibitor 73) is a potent and selective inhibitor of CDK2 with IC50 of 44 nM for CDK2/cyclin A.
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

CDK2-IN-73 (CDK2-IN-4, CDK2 inhibitor 73) is a potent and selective inhibitor ofCDK2with IC50 of 44 nM for CDK2/cyclin A.


Targets

Cdk2/cyclin A (Cell-free assay) 44 nM

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazines
Subclass Pyrimidines and pyrimidine derivatives
Intermediate Tree Nodes Not available
Direct Parent Phenylpyrimidines
Alternative Parents Biphenyls and derivatives  Benzenesulfonamides  Purines and purine derivatives  Benzenesulfonyl compounds  Aniline and substituted anilines  Aminopyrimidines and derivatives  Organosulfonamides  Imidazoles  Heteroaromatic compounds  Aminosulfonyl compounds  Secondary amines  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents 5-phenylpyrimidine - 4-phenylpyrimidine - Biphenyl - Benzenesulfonamide - Benzenesulfonyl group - Purine - Imidazopyrimidine - Aniline or substituted anilines - Aminopyrimidine - Benzenoid - Organosulfonic acid amide - Monocyclic benzene moiety - Heteroaromatic compound - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Imidazole - Azole - Azacycle - Secondary amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as phenylpyrimidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrimidine ring through a CC or CN bond. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors Not available

Associated Targets(Human)

A2058 (690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A-375 (9258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Calu-6 (398 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Skut1B (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MV4-11 (7307 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK4 Tclin Cyclin-dependent kinase 4/cyclin D1 (2340 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK1 Tchem Cyclin-dependent kinase 1/cyclin B1 (1887 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCNE1 Tchem Cyclin-dependent kinase 2/cyclin E1 (1877 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCNH Tbio Cyclin-dependent kinase 7/ cyclin H (714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCNT1 Tchem CDK9/cyclin T1 (2643 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SJSA-1 (970 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem CDK2/Cyclin A2 (2260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLM-13 (2241 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 4-[[6-(3-phenylphenyl)-7H-purin-2-yl]amino]benzenesulfonamide
INCHI InChI=1S/C23H18N6O2S/c24-32(30,31)19-11-9-18(10-12-19)27-23-28-20(21-22(29-23)26-14-25-21)17-8-4-7-16(13-17)15-5-2-1-3-6-15/h1-14H,(H2,24,30,31)(H2,25,26,27,28,29)
InChIKey FUGRWXRQJGJIER-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)C2=CC(=CC=C2)C3=C4C(=NC(=N3)NC5=CC=C(C=C5)S(=O)(=O)N)N=CN4
Isomeric SMILES C1=CC=C(C=C1)C2=CC(=CC=C2)C3=C4C(=NC(=N3)NC5=CC=C(C=C5)S(=O)(=O)N)N=CN4
PubChem CID 123132899
Molecular Weight 442.49

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
C2421177 Certificate of Analysis Feb 22, 2024 C412291
C2421178 Certificate of Analysis Feb 22, 2024 C412291
C2421381 Certificate of Analysis Feb 22, 2024 C412291
C2421382 Certificate of Analysis Feb 22, 2024 C412291
C2421384 Certificate of Analysis Feb 22, 2024 C412291
C2421385 Certificate of Analysis Feb 22, 2024 C412291
C2421387 Certificate of Analysis Feb 22, 2024 C412291

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 88 mg/mL (198.87 mM); Water: Insoluble; Ethanol: Insoluble;
Sensitivity Moisture sensitive; Light sensitive
Molecular Weight 442.500 g/mol
XLogP3 3.800
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 5
Exact Mass 442.121 Da
Monoisotopic Mass 442.121 Da
Topological Polar Surface Area 135.000 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 716.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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